Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361257776> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4361257776 abstract "<div>Abstract<p>Paclitaxel is a standard-of-care chemotherapy for breast cancer, despite the increasing recognition of its poor effectiveness in the treatment of patients with advanced disease. Here, we report that adenovirus-type 5 E1A-mediated elevation of the miRNA-processing enzyme Dicer is sufficient to enhance paclitaxel sensitization and reduce cancer stem-like cell properties in this setting. Elevating Dicer expression increased levels of the AXL kinase targeting miRNA miR-494, thereby repressing AXL expression to increase paclitaxel sensitivity. We found that Dicer expression was regulated at the transcription level by E1A, through activation of an MAPK14/CEBPα pathway. Our findings define a mechanism of E1A-mediated chemosensitization for paclitaxel, which is based upon the suppression of breast cancer stem-like cells, with potential implications for the diagnosis and treatment of breast cancer patients. <i>Cancer Res; 76(13); 3916–28. ©2016 AACR</i>.</p></div>" @default.
- W4361257776 created "2023-03-31" @default.
- W4361257776 creator A5036042183 @default.
- W4361257776 creator A5037168708 @default.
- W4361257776 creator A5038539457 @default.
- W4361257776 creator A5041370934 @default.
- W4361257776 creator A5046487166 @default.
- W4361257776 creator A5054499877 @default.
- W4361257776 creator A5076834432 @default.
- W4361257776 creator A5080236117 @default.
- W4361257776 creator A5090776323 @default.
- W4361257776 date "2023-03-30" @default.
- W4361257776 modified "2023-09-27" @default.
- W4361257776 title "Data from Dicer Elicits Paclitaxel Chemosensitization and Suppresses Cancer Stemness in Breast Cancer by Repressing AXL" @default.
- W4361257776 doi "https://doi.org/10.1158/0008-5472.c.6507534" @default.
- W4361257776 hasPublicationYear "2023" @default.
- W4361257776 type Work @default.
- W4361257776 citedByCount "0" @default.
- W4361257776 crossrefType "posted-content" @default.
- W4361257776 hasAuthorship W4361257776A5036042183 @default.
- W4361257776 hasAuthorship W4361257776A5037168708 @default.
- W4361257776 hasAuthorship W4361257776A5038539457 @default.
- W4361257776 hasAuthorship W4361257776A5041370934 @default.
- W4361257776 hasAuthorship W4361257776A5046487166 @default.
- W4361257776 hasAuthorship W4361257776A5054499877 @default.
- W4361257776 hasAuthorship W4361257776A5076834432 @default.
- W4361257776 hasAuthorship W4361257776A5080236117 @default.
- W4361257776 hasAuthorship W4361257776A5090776323 @default.
- W4361257776 hasConcept C104317684 @default.
- W4361257776 hasConcept C121608353 @default.
- W4361257776 hasConcept C126322002 @default.
- W4361257776 hasConcept C143998085 @default.
- W4361257776 hasConcept C145059251 @default.
- W4361257776 hasConcept C22615655 @default.
- W4361257776 hasConcept C2777292972 @default.
- W4361257776 hasConcept C2779867133 @default.
- W4361257776 hasConcept C502942594 @default.
- W4361257776 hasConcept C530470458 @default.
- W4361257776 hasConcept C54009773 @default.
- W4361257776 hasConcept C54355233 @default.
- W4361257776 hasConcept C55493867 @default.
- W4361257776 hasConcept C71924100 @default.
- W4361257776 hasConcept C81885089 @default.
- W4361257776 hasConcept C86803240 @default.
- W4361257776 hasConcept C98274493 @default.
- W4361257776 hasConceptScore W4361257776C104317684 @default.
- W4361257776 hasConceptScore W4361257776C121608353 @default.
- W4361257776 hasConceptScore W4361257776C126322002 @default.
- W4361257776 hasConceptScore W4361257776C143998085 @default.
- W4361257776 hasConceptScore W4361257776C145059251 @default.
- W4361257776 hasConceptScore W4361257776C22615655 @default.
- W4361257776 hasConceptScore W4361257776C2777292972 @default.
- W4361257776 hasConceptScore W4361257776C2779867133 @default.
- W4361257776 hasConceptScore W4361257776C502942594 @default.
- W4361257776 hasConceptScore W4361257776C530470458 @default.
- W4361257776 hasConceptScore W4361257776C54009773 @default.
- W4361257776 hasConceptScore W4361257776C54355233 @default.
- W4361257776 hasConceptScore W4361257776C55493867 @default.
- W4361257776 hasConceptScore W4361257776C71924100 @default.
- W4361257776 hasConceptScore W4361257776C81885089 @default.
- W4361257776 hasConceptScore W4361257776C86803240 @default.
- W4361257776 hasConceptScore W4361257776C98274493 @default.
- W4361257776 hasLocation W43612577761 @default.
- W4361257776 hasOpenAccess W4361257776 @default.
- W4361257776 hasPrimaryLocation W43612577761 @default.
- W4361257776 hasRelatedWork W1975859778 @default.
- W4361257776 hasRelatedWork W2098162459 @default.
- W4361257776 hasRelatedWork W2320478459 @default.
- W4361257776 hasRelatedWork W2338954311 @default.
- W4361257776 hasRelatedWork W2603750384 @default.
- W4361257776 hasRelatedWork W2794233632 @default.
- W4361257776 hasRelatedWork W2984941165 @default.
- W4361257776 hasRelatedWork W3033935954 @default.
- W4361257776 hasRelatedWork W3143026950 @default.
- W4361257776 hasRelatedWork W377899687 @default.
- W4361257776 isParatext "false" @default.
- W4361257776 isRetracted "false" @default.
- W4361257776 workType "article" @default.