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• W4361257788 abstract "<div>Abstract<p>Prostate cancer is the most frequently diagnosed and second most fatal nonskin cancer among men in the United States. African American men are two times more likely to develop and die of prostate cancer compared with men of other ancestries. Previous whole genome or exome tumor-sequencing studies of prostate cancer have primarily focused on men of European ancestry. In this study, we sequenced and characterized somatic mutations in aggressive (Gleason ≥7, stage ≥T2b) prostate tumors from 24 African American patients. We describe the locations and prevalence of small somatic mutations (up to 50 bases in length), copy number aberrations, and structural rearrangements in the tumor genomes compared with patient-matched normal genomes. We observed several mutation patterns consistent with previous studies, such as large copy number aberrations in chromosome 8 and complex rearrangement chains. However, <i>TMPRSS2-ERG</i> gene fusions and <i>PTEN</i> losses occurred in only 21% and 8% of the African American patients, respectively, far less common than in patients of European ancestry. We also identified mutations that appeared specific to or more common in African American patients, including a novel <i>CDC27-OAT</i> gene fusion occurring in 17% of patients. The genomic aberrations reported in this study warrant further investigation of their biologic significant role in the incidence and clinical outcomes of prostate cancer in African Americans. <i>Cancer Res; 76(7); 1860–8. ©2016 AACR</i>.</p></div>" @default.
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• W4361257788 date "2023-03-31" @default.
• W4361257788 modified "2023-09-25" @default.
• W4361257788 title "Data from Mutational Landscape of Aggressive Prostate Tumors in African American Men" @default.
• W4361257788 doi "https://doi.org/10.1158/0008-5472.c.6507984" @default.
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