Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361258324> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4361258324 abstract "<div>Abstract<p>Perineural tumor invasion of intrapancreatic nerves, neurogenic inflammation, and tumor metastases along extrapancreatic nerves are key features of pancreatic malignancies. Animal studies show that chronic pancreatic inflammation produces hypertrophy and hypersensitivity of pancreatic afferents and that sensory fibers may themselves drive inflammation via neurogenic mechanisms. Although genetic mutations are required for cancer development, inflammation has been shown to be a precipitating event that can accelerate the transition of precancerous lesions to cancer. These observations led us to hypothesize that inflammation that accompanies early phases of pancreatic ductal adenocarcinoma (PDAC) would produce pathologic changes in pancreatic neurons and innervation. Using a lineage-labeled genetically engineered mouse model of PDAC, we found that pancreatic neurotrophic factor mRNA expression and sensory innervation increased dramatically when only pancreatic intraepithelial neoplasia were apparent. These changes correlated with pain-related decreases in exploratory behavior and increased expression of nociceptive genes in sensory ganglia. At later stages, cells of pancreatic origin could be found in the celiac and sensory ganglia along with metastases to the spinal cord. These results demonstrate that the nervous system participates in all stages of PDAC, including those that precede the appearance of cancer. <i>Cancer Res; 74(6); 1718–27. ©2014 AACR</i>.</p></div>" @default.
- W4361258324 created "2023-03-31" @default.
- W4361258324 creator A5005072402 @default.
- W4361258324 creator A5015029502 @default.
- W4361258324 creator A5027305249 @default.
- W4361258324 creator A5033817939 @default.
- W4361258324 creator A5041384981 @default.
- W4361258324 creator A5056886978 @default.
- W4361258324 creator A5061237380 @default.
- W4361258324 creator A5078004886 @default.
- W4361258324 creator A5078209252 @default.
- W4361258324 creator A5084533633 @default.
- W4361258324 date "2023-03-30" @default.
- W4361258324 modified "2023-09-25" @default.
- W4361258324 title "Data from Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma" @default.
- W4361258324 doi "https://doi.org/10.1158/0008-5472.c.6505707.v1" @default.
- W4361258324 hasPublicationYear "2023" @default.
- W4361258324 type Work @default.
- W4361258324 citedByCount "0" @default.
- W4361258324 crossrefType "posted-content" @default.
- W4361258324 hasAuthorship W4361258324A5005072402 @default.
- W4361258324 hasAuthorship W4361258324A5015029502 @default.
- W4361258324 hasAuthorship W4361258324A5027305249 @default.
- W4361258324 hasAuthorship W4361258324A5033817939 @default.
- W4361258324 hasAuthorship W4361258324A5041384981 @default.
- W4361258324 hasAuthorship W4361258324A5056886978 @default.
- W4361258324 hasAuthorship W4361258324A5061237380 @default.
- W4361258324 hasAuthorship W4361258324A5078004886 @default.
- W4361258324 hasAuthorship W4361258324A5078209252 @default.
- W4361258324 hasAuthorship W4361258324A5084533633 @default.
- W4361258324 hasConcept C121608353 @default.
- W4361258324 hasConcept C126322002 @default.
- W4361258324 hasConcept C142724271 @default.
- W4361258324 hasConcept C169760540 @default.
- W4361258324 hasConcept C2776914184 @default.
- W4361258324 hasConcept C2777154038 @default.
- W4361258324 hasConcept C2778764654 @default.
- W4361258324 hasConcept C2780210213 @default.
- W4361258324 hasConcept C2781182431 @default.
- W4361258324 hasConcept C2909925829 @default.
- W4361258324 hasConcept C2992026798 @default.
- W4361258324 hasConcept C71924100 @default.
- W4361258324 hasConcept C86803240 @default.
- W4361258324 hasConcept C94487597 @default.
- W4361258324 hasConceptScore W4361258324C121608353 @default.
- W4361258324 hasConceptScore W4361258324C126322002 @default.
- W4361258324 hasConceptScore W4361258324C142724271 @default.
- W4361258324 hasConceptScore W4361258324C169760540 @default.
- W4361258324 hasConceptScore W4361258324C2776914184 @default.
- W4361258324 hasConceptScore W4361258324C2777154038 @default.
- W4361258324 hasConceptScore W4361258324C2778764654 @default.
- W4361258324 hasConceptScore W4361258324C2780210213 @default.
- W4361258324 hasConceptScore W4361258324C2781182431 @default.
- W4361258324 hasConceptScore W4361258324C2909925829 @default.
- W4361258324 hasConceptScore W4361258324C2992026798 @default.
- W4361258324 hasConceptScore W4361258324C71924100 @default.
- W4361258324 hasConceptScore W4361258324C86803240 @default.
- W4361258324 hasConceptScore W4361258324C94487597 @default.
- W4361258324 hasLocation W43612583241 @default.
- W4361258324 hasOpenAccess W4361258324 @default.
- W4361258324 hasPrimaryLocation W43612583241 @default.
- W4361258324 hasRelatedWork W1787071860 @default.
- W4361258324 hasRelatedWork W1986829345 @default.
- W4361258324 hasRelatedWork W2170039180 @default.
- W4361258324 hasRelatedWork W2767720677 @default.
- W4361258324 hasRelatedWork W3200087535 @default.
- W4361258324 hasRelatedWork W4210560360 @default.
- W4361258324 hasRelatedWork W4318192576 @default.
- W4361258324 hasRelatedWork W4318318110 @default.
- W4361258324 hasRelatedWork W4318321277 @default.
- W4361258324 hasRelatedWork W4319232702 @default.
- W4361258324 isParatext "false" @default.
- W4361258324 isRetracted "false" @default.
- W4361258324 workType "article" @default.