Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361258345> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4361258345 abstract "<div>Abstract<p>Oncogenic mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in several types of cancer, but the metabolic consequences of these genetic changes are not fully understood. In this study, we performed <sup>13</sup>C metabolic flux analysis on a panel of isogenic cell lines containing heterozygous IDH1/2 mutations. We observed that under hypoxic conditions, IDH1-mutant cells exhibited increased oxidative tricarboxylic acid metabolism along with decreased reductive glutamine metabolism, but not IDH2-mutant cells. However, selective inhibition of mutant IDH1 enzyme function could not reverse the defect in reductive carboxylation activity. Furthermore, this metabolic reprogramming increased the sensitivity of IDH1-mutant cells to hypoxia or electron transport chain inhibition <i>in vitro</i>. Lastly, IDH1-mutant cells also grew poorly as subcutaneous xenografts within a hypoxic <i>in vivo</i> microenvironment. Together, our results suggest therapeutic opportunities to exploit the metabolic vulnerabilities specific to IDH1 mutation. <i>Cancer Res; 74(12); 3317–31. ©2014 AACR</i>.</p></div>" @default.
- W4361258345 created "2023-03-31" @default.
- W4361258345 creator A5000162907 @default.
- W4361258345 creator A5005072713 @default.
- W4361258345 creator A5006842434 @default.
- W4361258345 creator A5010408081 @default.
- W4361258345 creator A5013957802 @default.
- W4361258345 creator A5018222519 @default.
- W4361258345 creator A5022499876 @default.
- W4361258345 creator A5023112489 @default.
- W4361258345 creator A5030056081 @default.
- W4361258345 creator A5042375667 @default.
- W4361258345 creator A5044405240 @default.
- W4361258345 creator A5044410512 @default.
- W4361258345 creator A5047996841 @default.
- W4361258345 creator A5069727190 @default.
- W4361258345 creator A5070718217 @default.
- W4361258345 creator A5080510903 @default.
- W4361258345 creator A5082143408 @default.
- W4361258345 creator A5084359529 @default.
- W4361258345 creator A5084455368 @default.
- W4361258345 creator A5086522167 @default.
- W4361258345 date "2023-03-30" @default.
- W4361258345 modified "2023-09-30" @default.
- W4361258345 title "Data from IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism" @default.
- W4361258345 doi "https://doi.org/10.1158/0008-5472.c.6506604.v1" @default.
- W4361258345 hasPublicationYear "2023" @default.
- W4361258345 type Work @default.
- W4361258345 citedByCount "0" @default.
- W4361258345 crossrefType "posted-content" @default.
- W4361258345 hasAuthorship W4361258345A5000162907 @default.
- W4361258345 hasAuthorship W4361258345A5005072713 @default.
- W4361258345 hasAuthorship W4361258345A5006842434 @default.
- W4361258345 hasAuthorship W4361258345A5010408081 @default.
- W4361258345 hasAuthorship W4361258345A5013957802 @default.
- W4361258345 hasAuthorship W4361258345A5018222519 @default.
- W4361258345 hasAuthorship W4361258345A5022499876 @default.
- W4361258345 hasAuthorship W4361258345A5023112489 @default.
- W4361258345 hasAuthorship W4361258345A5030056081 @default.
- W4361258345 hasAuthorship W4361258345A5042375667 @default.
- W4361258345 hasAuthorship W4361258345A5044405240 @default.
- W4361258345 hasAuthorship W4361258345A5044410512 @default.
- W4361258345 hasAuthorship W4361258345A5047996841 @default.
- W4361258345 hasAuthorship W4361258345A5069727190 @default.
- W4361258345 hasAuthorship W4361258345A5070718217 @default.
- W4361258345 hasAuthorship W4361258345A5080510903 @default.
- W4361258345 hasAuthorship W4361258345A5082143408 @default.
- W4361258345 hasAuthorship W4361258345A5084359529 @default.
- W4361258345 hasAuthorship W4361258345A5084455368 @default.
- W4361258345 hasAuthorship W4361258345A5086522167 @default.
- W4361258345 hasConcept C104317684 @default.
- W4361258345 hasConcept C127848430 @default.
- W4361258345 hasConcept C143065580 @default.
- W4361258345 hasConcept C153911025 @default.
- W4361258345 hasConcept C165135838 @default.
- W4361258345 hasConcept C181199279 @default.
- W4361258345 hasConcept C185592680 @default.
- W4361258345 hasConcept C192989942 @default.
- W4361258345 hasConcept C20251656 @default.
- W4361258345 hasConcept C2776059313 @default.
- W4361258345 hasConcept C2777150147 @default.
- W4361258345 hasConcept C2779349466 @default.
- W4361258345 hasConcept C515207424 @default.
- W4361258345 hasConcept C55493867 @default.
- W4361258345 hasConcept C57600042 @default.
- W4361258345 hasConcept C62231903 @default.
- W4361258345 hasConcept C86803240 @default.
- W4361258345 hasConceptScore W4361258345C104317684 @default.
- W4361258345 hasConceptScore W4361258345C127848430 @default.
- W4361258345 hasConceptScore W4361258345C143065580 @default.
- W4361258345 hasConceptScore W4361258345C153911025 @default.
- W4361258345 hasConceptScore W4361258345C165135838 @default.
- W4361258345 hasConceptScore W4361258345C181199279 @default.
- W4361258345 hasConceptScore W4361258345C185592680 @default.
- W4361258345 hasConceptScore W4361258345C192989942 @default.
- W4361258345 hasConceptScore W4361258345C20251656 @default.
- W4361258345 hasConceptScore W4361258345C2776059313 @default.
- W4361258345 hasConceptScore W4361258345C2777150147 @default.
- W4361258345 hasConceptScore W4361258345C2779349466 @default.
- W4361258345 hasConceptScore W4361258345C515207424 @default.
- W4361258345 hasConceptScore W4361258345C55493867 @default.
- W4361258345 hasConceptScore W4361258345C57600042 @default.
- W4361258345 hasConceptScore W4361258345C62231903 @default.
- W4361258345 hasConceptScore W4361258345C86803240 @default.
- W4361258345 hasLocation W43612583451 @default.
- W4361258345 hasOpenAccess W4361258345 @default.
- W4361258345 hasPrimaryLocation W43612583451 @default.
- W4361258345 hasRelatedWork W152907091 @default.
- W4361258345 hasRelatedWork W2029813482 @default.
- W4361258345 hasRelatedWork W2087383467 @default.
- W4361258345 hasRelatedWork W2134831827 @default.
- W4361258345 hasRelatedWork W2155800445 @default.
- W4361258345 hasRelatedWork W2466647218 @default.
- W4361258345 hasRelatedWork W2588160499 @default.
- W4361258345 hasRelatedWork W2887948931 @default.
- W4361258345 hasRelatedWork W3032643463 @default.
- W4361258345 hasRelatedWork W3036528549 @default.
- W4361258345 isParatext "false" @default.
- W4361258345 isRetracted "false" @default.
- W4361258345 workType "article" @default.