Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361258472> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4361258472 abstract "<div>Abstract<p>The genome of a subset of non–small-cell lung cancers (NSCLC) harbors a small inversion within chromosome 2 that gives rise to a transforming fusion gene, <i>EML4-ALK</i>, which encodes an activated protein tyrosine kinase. Although breakpoints within <i>EML4</i> have been identified in introns 13 and 20, giving rise to variants 1 and 2, respectively, of <i>EML4-ALK</i>, it has remained unclear whether other isoforms of the fusion gene are present in NSCLC cells. We have now screened NSCLC specimens for other in-frame fusion cDNAs that contain both <i>EML4</i> and <i>ALK</i> sequences. Two slightly different fusion cDNAs in which exon 6 of <i>EML4</i> was joined to exon 20 of <i>ALK</i> were each identified in two individuals of the cohort. Whereas one cDNA contained only exons 1 to 6 of <i>EML4</i> (variant 3a), the other also contained an additional 33-bp sequence derived from intron 6 of <i>EML4</i> (variant 3b). The protein encoded by the latter cDNA thus contained an insertion of 11 amino acids between the EML4 and ALK sequences of that encoded by the former. Both variants 3a and 3b of EML4-ALK exhibited marked transforming activity <i>in vitro</i> as well as oncogenic activity <i>in vivo</i>. A lung cancer cell line expressing endogenous variant 3 of EML4-ALK underwent cell death on exposure to a specific inhibitor of ALK catalytic activity. These data increase the frequency of <i>EML4-ALK</i>–positive NSCLC tumors and bolster the clinical relevance of this oncogenic kinase. [Cancer Res 2008;68(13):4971–6]</p></div>" @default.
- W4361258472 created "2023-03-31" @default.
- W4361258472 creator A5000072465 @default.
- W4361258472 creator A5001514470 @default.
- W4361258472 creator A5002497469 @default.
- W4361258472 creator A5004532315 @default.
- W4361258472 creator A5004738203 @default.
- W4361258472 creator A5005879454 @default.
- W4361258472 creator A5015902479 @default.
- W4361258472 creator A5017167697 @default.
- W4361258472 creator A5033862426 @default.
- W4361258472 creator A5037983434 @default.
- W4361258472 creator A5044544485 @default.
- W4361258472 creator A5049785426 @default.
- W4361258472 creator A5049835634 @default.
- W4361258472 creator A5066264636 @default.
- W4361258472 creator A5074950427 @default.
- W4361258472 creator A5079182220 @default.
- W4361258472 creator A5081671818 @default.
- W4361258472 creator A5090560513 @default.
- W4361258472 date "2023-03-30" @default.
- W4361258472 modified "2023-09-30" @default.
- W4361258472 title "Data from Identification of Novel Isoforms of the <i>EML4-ALK</i> Transforming Gene in Non–Small Cell Lung Cancer" @default.
- W4361258472 doi "https://doi.org/10.1158/0008-5472.c.6497381" @default.
- W4361258472 hasPublicationYear "2023" @default.
- W4361258472 type Work @default.
- W4361258472 citedByCount "0" @default.
- W4361258472 crossrefType "posted-content" @default.
- W4361258472 hasAuthorship W4361258472A5000072465 @default.
- W4361258472 hasAuthorship W4361258472A5001514470 @default.
- W4361258472 hasAuthorship W4361258472A5002497469 @default.
- W4361258472 hasAuthorship W4361258472A5004532315 @default.
- W4361258472 hasAuthorship W4361258472A5004738203 @default.
- W4361258472 hasAuthorship W4361258472A5005879454 @default.
- W4361258472 hasAuthorship W4361258472A5015902479 @default.
- W4361258472 hasAuthorship W4361258472A5017167697 @default.
- W4361258472 hasAuthorship W4361258472A5033862426 @default.
- W4361258472 hasAuthorship W4361258472A5037983434 @default.
- W4361258472 hasAuthorship W4361258472A5044544485 @default.
- W4361258472 hasAuthorship W4361258472A5049785426 @default.
- W4361258472 hasAuthorship W4361258472A5049835634 @default.
- W4361258472 hasAuthorship W4361258472A5066264636 @default.
- W4361258472 hasAuthorship W4361258472A5074950427 @default.
- W4361258472 hasAuthorship W4361258472A5079182220 @default.
- W4361258472 hasAuthorship W4361258472A5081671818 @default.
- W4361258472 hasAuthorship W4361258472A5090560513 @default.
- W4361258472 hasConcept C104317684 @default.
- W4361258472 hasConcept C111829193 @default.
- W4361258472 hasConcept C123894998 @default.
- W4361258472 hasConcept C153911025 @default.
- W4361258472 hasConcept C36823959 @default.
- W4361258472 hasConcept C40767141 @default.
- W4361258472 hasConcept C502942594 @default.
- W4361258472 hasConcept C54355233 @default.
- W4361258472 hasConcept C86803240 @default.
- W4361258472 hasConcept C94671646 @default.
- W4361258472 hasConceptScore W4361258472C104317684 @default.
- W4361258472 hasConceptScore W4361258472C111829193 @default.
- W4361258472 hasConceptScore W4361258472C123894998 @default.
- W4361258472 hasConceptScore W4361258472C153911025 @default.
- W4361258472 hasConceptScore W4361258472C36823959 @default.
- W4361258472 hasConceptScore W4361258472C40767141 @default.
- W4361258472 hasConceptScore W4361258472C502942594 @default.
- W4361258472 hasConceptScore W4361258472C54355233 @default.
- W4361258472 hasConceptScore W4361258472C86803240 @default.
- W4361258472 hasConceptScore W4361258472C94671646 @default.
- W4361258472 hasLocation W43612584721 @default.
- W4361258472 hasOpenAccess W4361258472 @default.
- W4361258472 hasPrimaryLocation W43612584721 @default.
- W4361258472 hasRelatedWork W1999232590 @default.
- W4361258472 hasRelatedWork W2037918956 @default.
- W4361258472 hasRelatedWork W2039352533 @default.
- W4361258472 hasRelatedWork W2059736436 @default.
- W4361258472 hasRelatedWork W2072834586 @default.
- W4361258472 hasRelatedWork W2085975240 @default.
- W4361258472 hasRelatedWork W2092554027 @default.
- W4361258472 hasRelatedWork W2131379448 @default.
- W4361258472 hasRelatedWork W2418488235 @default.
- W4361258472 hasRelatedWork W4242521457 @default.
- W4361258472 isParatext "false" @default.
- W4361258472 isRetracted "false" @default.
- W4361258472 workType "article" @default.