Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361265730> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4361265730 abstract "<div>Abstract<p>Rac1b is a tumor-specific splice variant of the Rac1 GTPase that displays limited functional similarities to Rac1. We have shown previously a novel cross-talk between Rac1 and β-catenin, which induces canonical Wnt pathway activation in colorectal cancer cells. This prompted us to investigate if Rac1b, frequently overexpressed in colon tumors, contributes to Wnt pathway dysregulation. We show that Rac1b overexpression stimulates Tcf-mediated gene transcription, whereas depletion of Rac1b results in decreased expression of the Wnt target gene <i>cyclin D1</i>. Reconstitution experiments revealed an important difference between Rac1 and Rac1b such that Rac1b was capable of functionally interacting with Dishevelled-3 (Dvl-3) but not β-catenin to mediate synergistic induction of Wnt target genes. In agreement, Dvl-3 but not β-catenin caused increased activation of Rac1b levels, which may explain the functional cooperativity displayed in transcription assays. Furthermore, we show that Rac1b negatively regulates E-cadherin expression and results in decreased adhesion of colorectal cancer cells. RNA interference–mediated suppression of Rac1b resulted in reduced expression of <i>Slug</i>, a specific transcriptional repressor of E-cadherin, and a concomitant increase in E-cadherin transcript levels was observed. Intriguingly, mutation of the polybasic region of Rac1b resulted in complete loss of Rac1b stimulatory effects on transcription and suppressive effects on adhesion, indicating the importance of nuclear and membrane localization of Rac1b. Our results suggest that Rac1b overexpression may facilitate tumor progression by enhancing Dvl-3–mediated Wnt pathway signaling and induction of Wnt target genes specifically involved in decreasing the adhesive properties of colorectal cancer cells. [Cancer Res 2007;67(6):2469–79]</p></div>" @default.
- W4361265730 created "2023-03-31" @default.
- W4361265730 creator A5029852995 @default.
- W4361265730 creator A5035993142 @default.
- W4361265730 creator A5057092796 @default.
- W4361265730 creator A5061947655 @default.
- W4361265730 creator A5090666061 @default.
- W4361265730 date "2023-03-30" @default.
- W4361265730 modified "2023-09-30" @default.
- W4361265730 title "Data from Activation of Tumor-Specific Splice Variant Rac1b by Dishevelled Promotes Canonical Wnt Signaling and Decreased Adhesion of Colorectal Cancer Cells" @default.
- W4361265730 doi "https://doi.org/10.1158/0008-5472.c.6495072.v1" @default.
- W4361265730 hasPublicationYear "2023" @default.
- W4361265730 type Work @default.
- W4361265730 citedByCount "0" @default.
- W4361265730 crossrefType "posted-content" @default.
- W4361265730 hasAuthorship W4361265730A5029852995 @default.
- W4361265730 hasAuthorship W4361265730A5035993142 @default.
- W4361265730 hasAuthorship W4361265730A5057092796 @default.
- W4361265730 hasAuthorship W4361265730A5061947655 @default.
- W4361265730 hasAuthorship W4361265730A5090666061 @default.
- W4361265730 hasBestOaLocation W43612657302 @default.
- W4361265730 hasConcept C104317684 @default.
- W4361265730 hasConcept C107300179 @default.
- W4361265730 hasConcept C137620995 @default.
- W4361265730 hasConcept C2775928862 @default.
- W4361265730 hasConcept C2779717556 @default.
- W4361265730 hasConcept C502942594 @default.
- W4361265730 hasConcept C54355233 @default.
- W4361265730 hasConcept C62478195 @default.
- W4361265730 hasConcept C86339819 @default.
- W4361265730 hasConcept C86803240 @default.
- W4361265730 hasConcept C95444343 @default.
- W4361265730 hasConceptScore W4361265730C104317684 @default.
- W4361265730 hasConceptScore W4361265730C107300179 @default.
- W4361265730 hasConceptScore W4361265730C137620995 @default.
- W4361265730 hasConceptScore W4361265730C2775928862 @default.
- W4361265730 hasConceptScore W4361265730C2779717556 @default.
- W4361265730 hasConceptScore W4361265730C502942594 @default.
- W4361265730 hasConceptScore W4361265730C54355233 @default.
- W4361265730 hasConceptScore W4361265730C62478195 @default.
- W4361265730 hasConceptScore W4361265730C86339819 @default.
- W4361265730 hasConceptScore W4361265730C86803240 @default.
- W4361265730 hasConceptScore W4361265730C95444343 @default.
- W4361265730 hasLocation W43612657301 @default.
- W4361265730 hasLocation W43612657302 @default.
- W4361265730 hasOpenAccess W4361265730 @default.
- W4361265730 hasPrimaryLocation W43612657301 @default.
- W4361265730 hasRelatedWork W167797417 @default.
- W4361265730 hasRelatedWork W1981311091 @default.
- W4361265730 hasRelatedWork W1994979890 @default.
- W4361265730 hasRelatedWork W1997085708 @default.
- W4361265730 hasRelatedWork W2033984390 @default.
- W4361265730 hasRelatedWork W2054062221 @default.
- W4361265730 hasRelatedWork W2109767902 @default.
- W4361265730 hasRelatedWork W2152975437 @default.
- W4361265730 hasRelatedWork W2370215344 @default.
- W4361265730 hasRelatedWork W2966286774 @default.
- W4361265730 isParatext "false" @default.
- W4361265730 isRetracted "false" @default.
- W4361265730 workType "article" @default.