Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361265758> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4361265758 abstract "<div>Abstract<p>When properly activated, macrophages can be tumoricidal, thus making them attractive additions to standard cancer therapies. To this end, tolerance and activity of human autologous IFN-γ-activated macrophages, produced in large scale for clinical use (MAK cells), have been assessed in pilot trials in cancer patients. In the present study, we tested the hypothesis that activation of IFN regulatory factor (IRF)-3 and IRF-7, with subsequent type I IFN production, may be involved in the acquisition of new antitumor functions by macrophages. Adenoviral vectors were generated for the delivery of constitutively active forms of IRF-3 (Ad-IRF-3) or IRF-7 (Ad-IRF-7) into primary human macrophages. Cell death was observed in Ad-IRF-3-transduced macrophages, whereas Ad-IRF-7-transduced macrophages produced type I IFNs and displayed increased expression of genes encoding tumor necrosis factor (TNF)–related apoptosis-inducing ligand, interleukin (IL)-12, IL-15, and CD80, persisting for at least 96 hours. Expression of <i>iNOS, TNF-α, FasL, IL-1</i>, and <i>IL-6</i> genes was unaltered by Ad-IRF-7 transduction. Interestingly, Ad-IRF-3 or Ad-IRF-7 transduction negatively regulated the transcription of protumorigenic genes encoding vascular endothelial growth factor and matrix metalloproteinase-2. Furthermore, Ad-IRF-7-transduced macrophages exerted a cytostatic activity on different cancer cell lines, including SK-BR-3, MCF-7, and COLO-205; the latter cells were shown previously to be insensitive to MAK cells. In conclusion, transduction of active forms of IRF-3 or IRF-7 differentially modulate the apoptotic and antitumor properties of primary macrophages, with active IRF-7 leading to the acquisition of novel antitumor effector functions. (Cancer Res 2006; 66(21): 10576-85)</p></div>" @default.
- W4361265758 created "2023-03-31" @default.
- W4361265758 creator A5002868098 @default.
- W4361265758 creator A5003682597 @default.
- W4361265758 creator A5004289043 @default.
- W4361265758 creator A5009280530 @default.
- W4361265758 creator A5042737704 @default.
- W4361265758 creator A5048348913 @default.
- W4361265758 creator A5068999452 @default.
- W4361265758 creator A5073148390 @default.
- W4361265758 creator A5084642801 @default.
- W4361265758 date "2023-03-30" @default.
- W4361265758 modified "2023-10-16" @default.
- W4361265758 title "Data from Distinct Roles for IFN Regulatory Factor (IRF)-3 and IRF-7 in the Activation of Antitumor Properties of Human Macrophages" @default.
- W4361265758 doi "https://doi.org/10.1158/0008-5472.c.6494991" @default.
- W4361265758 hasPublicationYear "2023" @default.
- W4361265758 type Work @default.
- W4361265758 citedByCount "0" @default.
- W4361265758 crossrefType "posted-content" @default.
- W4361265758 hasAuthorship W4361265758A5002868098 @default.
- W4361265758 hasAuthorship W4361265758A5003682597 @default.
- W4361265758 hasAuthorship W4361265758A5004289043 @default.
- W4361265758 hasAuthorship W4361265758A5009280530 @default.
- W4361265758 hasAuthorship W4361265758A5042737704 @default.
- W4361265758 hasAuthorship W4361265758A5048348913 @default.
- W4361265758 hasAuthorship W4361265758A5068999452 @default.
- W4361265758 hasAuthorship W4361265758A5073148390 @default.
- W4361265758 hasAuthorship W4361265758A5084642801 @default.
- W4361265758 hasConcept C153911025 @default.
- W4361265758 hasConcept C154317977 @default.
- W4361265758 hasConcept C17991360 @default.
- W4361265758 hasConcept C190283241 @default.
- W4361265758 hasConcept C202751555 @default.
- W4361265758 hasConcept C203014093 @default.
- W4361265758 hasConcept C2778297628 @default.
- W4361265758 hasConcept C31573885 @default.
- W4361265758 hasConcept C39347974 @default.
- W4361265758 hasConcept C502942594 @default.
- W4361265758 hasConcept C55493867 @default.
- W4361265758 hasConcept C66008609 @default.
- W4361265758 hasConcept C86803240 @default.
- W4361265758 hasConcept C95444343 @default.
- W4361265758 hasConceptScore W4361265758C153911025 @default.
- W4361265758 hasConceptScore W4361265758C154317977 @default.
- W4361265758 hasConceptScore W4361265758C17991360 @default.
- W4361265758 hasConceptScore W4361265758C190283241 @default.
- W4361265758 hasConceptScore W4361265758C202751555 @default.
- W4361265758 hasConceptScore W4361265758C203014093 @default.
- W4361265758 hasConceptScore W4361265758C2778297628 @default.
- W4361265758 hasConceptScore W4361265758C31573885 @default.
- W4361265758 hasConceptScore W4361265758C39347974 @default.
- W4361265758 hasConceptScore W4361265758C502942594 @default.
- W4361265758 hasConceptScore W4361265758C55493867 @default.
- W4361265758 hasConceptScore W4361265758C66008609 @default.
- W4361265758 hasConceptScore W4361265758C86803240 @default.
- W4361265758 hasConceptScore W4361265758C95444343 @default.
- W4361265758 hasLocation W43612657581 @default.
- W4361265758 hasOpenAccess W4361265758 @default.
- W4361265758 hasPrimaryLocation W43612657581 @default.
- W4361265758 hasRelatedWork W1976821497 @default.
- W4361265758 hasRelatedWork W2011555456 @default.
- W4361265758 hasRelatedWork W2064216603 @default.
- W4361265758 hasRelatedWork W2091714257 @default.
- W4361265758 hasRelatedWork W2354587099 @default.
- W4361265758 hasRelatedWork W2383837582 @default.
- W4361265758 hasRelatedWork W2396671451 @default.
- W4361265758 hasRelatedWork W3146697515 @default.
- W4361265758 hasRelatedWork W3196582013 @default.
- W4361265758 hasRelatedWork W396249626 @default.
- W4361265758 isParatext "false" @default.
- W4361265758 isRetracted "false" @default.
- W4361265758 workType "article" @default.