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- W4361265800 abstract "<div>Abstract<p>The HMGA1 protein is a major factor in chromatin architecture and gene control. It plays a critical role in neoplastic transformation. In fact, blockage of HMGA1 synthesis prevents rat thyroid cell transformation by murine transforming retroviruses, and an adenovirus carrying the <i>HMGA1</i> gene in the antisense orientation induces apoptotic cell death in anaplastic human thyroid carcinoma cell lines, but not in normal thyroid cells. Moreover, both <i>in vitro</i> and <i>in vivo</i> studies have established the oncogenic role of the <i>HMGA1</i> gene. In this study, to define HMGA1 function <i>in vivo</i>, we examined the consequences of disrupting the <i>Hmga1</i> gene in mice. Both heterozygous and homozygous mice for the <i>Hmga1</i>-null allele show cardiac hypertrophy due to the direct role of HMGA1 on cardiomyocytic cell growth regulation. These mice also developed hematologic malignancies, including B cell lymphoma and myeloid granuloerythroblastic leukemia. The B cell expansion and the increased expression of the RAG1/2 endonuclease, observed in HMGA1-knockout spleen tissues, might be responsible for the high rate of abnormal <i>IgH</i> rearrangements observed in these neoplasias. Therefore, the data reported here indicate the critical role of HMGA1 in heart development and growth, and reveal an unsuspected antioncogenic potential for this gene in hematologic malignancies. (Cancer Res 2006; 66(5): 2536-43)</p></div>" @default.
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- W4361265800 date "2023-03-30" @default.
- W4361265800 modified "2023-10-17" @default.
- W4361265800 title "Data from Haploinsufficiency of the <i>Hmga1</i> Gene Causes Cardiac Hypertrophy and Myelo-Lymphoproliferative Disorders in Mice" @default.
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