Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361265810> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4361265810 abstract "<div>Abstract<p>Transforming growth factor β (TGF-β) can act as suppressor and promoter of cancer progression. Intracellular Smad proteins (i.e., receptor regulated Smads and common mediator Smad4) play a pivotal role in mediating antimitogenic and proapoptotic effects of TGF-β, but their function in TGF-β-induced invasion and metastasis is unclear. Here, we have investigated the role of Smad4 in a cellular and mouse model for TGF-β-induced breast cancer progression. Consistent with its tumor suppressor function, specific silencing of Smad4 in NMuMG mammary gland epithelial cells using small hairpin RNA (shRNA)–expressing RNAi vectors strongly mitigated TGF-β-induced growth inhibition and apoptosis. Smad4 knockdown also potently inhibited TGF-β-induced epithelial to mesenchymal transition of NMuMG cells as measured by morphologic transformation from epithelial to fibroblast-like cells, formation of stress fibers, inhibition of E-cadherin expression, and gain of expression of various mesenchymal markers. Furthermore, we show that knockdown of Smad4 in MDA-MB-231 breast cancer cells strongly inhibited the frequency of bone metastasis in nude mice by 75% and significantly increased metastasis-free survival. Communication of MDA-MB-231 cells with the bone microenvironment, which is needed for optimal tumor cell growth and metastasis, may be affected in Smad4 knockdown cells as TGF-β-induced expression of interleukin 11 was attenuated on Smad4 knockdown. Taken together, our results show that Smad4 plays an important role in both tumor suppression and progression of breast cancer cells. (Cancer Res 2006; 66(4): 2202-9)</p></div>" @default.
- W4361265810 created "2023-03-31" @default.
- W4361265810 creator A5000304131 @default.
- W4361265810 creator A5000644268 @default.
- W4361265810 creator A5009948898 @default.
- W4361265810 creator A5018672077 @default.
- W4361265810 creator A5023166091 @default.
- W4361265810 creator A5064012002 @default.
- W4361265810 creator A5086525291 @default.
- W4361265810 date "2023-03-30" @default.
- W4361265810 modified "2023-10-16" @default.
- W4361265810 title "Data from The Tumor Suppressor Smad4 Is Required for Transforming Growth Factor β–Induced Epithelial to Mesenchymal Transition and Bone Metastasis of Breast Cancer Cells" @default.
- W4361265810 doi "https://doi.org/10.1158/0008-5472.c.6494984.v1" @default.
- W4361265810 hasPublicationYear "2023" @default.
- W4361265810 type Work @default.
- W4361265810 citedByCount "0" @default.
- W4361265810 crossrefType "posted-content" @default.
- W4361265810 hasAuthorship W4361265810A5000304131 @default.
- W4361265810 hasAuthorship W4361265810A5000644268 @default.
- W4361265810 hasAuthorship W4361265810A5009948898 @default.
- W4361265810 hasAuthorship W4361265810A5018672077 @default.
- W4361265810 hasAuthorship W4361265810A5023166091 @default.
- W4361265810 hasAuthorship W4361265810A5064012002 @default.
- W4361265810 hasAuthorship W4361265810A5086525291 @default.
- W4361265810 hasConcept C104317684 @default.
- W4361265810 hasConcept C118131993 @default.
- W4361265810 hasConcept C119056186 @default.
- W4361265810 hasConcept C121608353 @default.
- W4361265810 hasConcept C173396325 @default.
- W4361265810 hasConcept C190232843 @default.
- W4361265810 hasConcept C190283241 @default.
- W4361265810 hasConcept C2777783956 @default.
- W4361265810 hasConcept C2778025950 @default.
- W4361265810 hasConcept C2778229498 @default.
- W4361265810 hasConcept C2779013556 @default.
- W4361265810 hasConcept C2779256057 @default.
- W4361265810 hasConcept C2781080636 @default.
- W4361265810 hasConcept C502942594 @default.
- W4361265810 hasConcept C530470458 @default.
- W4361265810 hasConcept C54355233 @default.
- W4361265810 hasConcept C55493867 @default.
- W4361265810 hasConcept C76419328 @default.
- W4361265810 hasConcept C86803240 @default.
- W4361265810 hasConcept C95444343 @default.
- W4361265810 hasConcept C96232424 @default.
- W4361265810 hasConceptScore W4361265810C104317684 @default.
- W4361265810 hasConceptScore W4361265810C118131993 @default.
- W4361265810 hasConceptScore W4361265810C119056186 @default.
- W4361265810 hasConceptScore W4361265810C121608353 @default.
- W4361265810 hasConceptScore W4361265810C173396325 @default.
- W4361265810 hasConceptScore W4361265810C190232843 @default.
- W4361265810 hasConceptScore W4361265810C190283241 @default.
- W4361265810 hasConceptScore W4361265810C2777783956 @default.
- W4361265810 hasConceptScore W4361265810C2778025950 @default.
- W4361265810 hasConceptScore W4361265810C2778229498 @default.
- W4361265810 hasConceptScore W4361265810C2779013556 @default.
- W4361265810 hasConceptScore W4361265810C2779256057 @default.
- W4361265810 hasConceptScore W4361265810C2781080636 @default.
- W4361265810 hasConceptScore W4361265810C502942594 @default.
- W4361265810 hasConceptScore W4361265810C530470458 @default.
- W4361265810 hasConceptScore W4361265810C54355233 @default.
- W4361265810 hasConceptScore W4361265810C55493867 @default.
- W4361265810 hasConceptScore W4361265810C76419328 @default.
- W4361265810 hasConceptScore W4361265810C86803240 @default.
- W4361265810 hasConceptScore W4361265810C95444343 @default.
- W4361265810 hasConceptScore W4361265810C96232424 @default.
- W4361265810 hasLocation W43612658101 @default.
- W4361265810 hasOpenAccess W4361265810 @default.
- W4361265810 hasPrimaryLocation W43612658101 @default.
- W4361265810 hasRelatedWork W2059174198 @default.
- W4361265810 hasRelatedWork W2075201743 @default.
- W4361265810 hasRelatedWork W2154708791 @default.
- W4361265810 hasRelatedWork W2519352828 @default.
- W4361265810 hasRelatedWork W2789798659 @default.
- W4361265810 hasRelatedWork W2800500152 @default.
- W4361265810 hasRelatedWork W3086196372 @default.
- W4361265810 hasRelatedWork W3175565016 @default.
- W4361265810 hasRelatedWork W4361252124 @default.
- W4361265810 hasRelatedWork W4361265810 @default.
- W4361265810 isParatext "false" @default.
- W4361265810 isRetracted "false" @default.
- W4361265810 workType "article" @default.