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- W4361266199 abstract "<div>Abstract<p>MCT-1 is an oncogene that was initially identified in a human T cell lymphoma and has been shown to induce cell proliferation as well as activate survival-related pathways. MCT-1 contains the PUA domain, a recently described RNA-binding domain that is found in several tRNA and rRNA modification enzymes. Here, we established that MCT-1 protein interacts with the cap complex through its PUA domain and recruits the density-regulated protein (DENR/DRP), containing the SUI1 translation initiation domain. Through the use of microarray analysis on polysome-associated mRNAs, we showed that up-regulation of MCT-1 was able to modulate the translation profiles of BCL2L2, TFDP1, MRE11A, cyclin D1, and E2F1 mRNAs, despite equivalent levels of mRNAs in the cytoplasm. Our data establish a role for MCT-1 in translational regulation, and support a linkage between translational control and oncogenesis. (Cancer Res 2006; 66(18): 8994-9001)</p></div>" @default.
- W4361266199 created "2023-03-31" @default.
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- W4361266199 date "2023-03-30" @default.
- W4361266199 modified "2023-09-27" @default.
- W4361266199 title "Data from MCT-1 Protein Interacts with the Cap Complex and Modulates Messenger RNA Translational Profiles" @default.
- W4361266199 doi "https://doi.org/10.1158/0008-5472.c.6494619" @default.
- W4361266199 hasPublicationYear "2023" @default.
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