FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361268533> ?p ?o ?g. }

• W4361268533 endingPage "109511" @default.
• W4361268533 startingPage "109511" @default.
• W4361268533 abstract "Delta opioid receptors (DOPs) play an important role in depression and other mood disorders. However, little is known about the underlying physiological mechanisms. The hypothalamic–pituitary–adrenal axis, adult hippocampal neurogenesis, and neuroinflammation are regarded as key pathophysiological factors in depression. In this study, we investigated the influence of DOP activation on those factors in a valid animal model of depression, chronic vicarious social defeat stress (cVSDS) mice. cVSDS mice (male C57BL/6J mice) were produced following a 10-day exposure to witness of social defeat stress, and each evaluation was performed more than 28 days after the stress period. Repeated administrations to cVSDS mice with a selective DOP agonist, KNT-127, both during (10 days) and after (28 days) the stress period respectively improved their decreased social interaction behaviors and increased serum corticosterone levels. When administered during the stress period, KNT-127 suppressed decreases in the hippocampal newborn neuron survival rate in cVSDS mice. Moreover, in both administration paradigms, KNT-127 reduced the number of Iba-1- and CD11b-positive cells in the subgranular zone and the granule cell layer of the hippocampal dentate gyrus, indicating a suppression of cVSDS-induced microglial overactivation. These results suggest that KNT-127 acts over the hypothalamic–pituitary–adrenal axis and regulates neurogenesis and neuroinflammation resulting in anti-stress effects, and the antidepressant-like effects of the DOP agonist are implicated in the suppression of the neuroinflammation. This study presents a new finding on the effects of repeated DOP activations on the pathophysiological states of depression." @default.
• W4361268533 created "2023-03-31" @default.
• W4361268533 creator A5016291372 @default.
• W4361268533 creator A5029754237 @default.
• W4361268533 creator A5043346994 @default.
• W4361268533 creator A5068736197 @default.
• W4361268533 creator A5084048161 @default.
• W4361268533 date "2023-07-01" @default.
• W4361268533 modified "2023-10-16" @default.
• W4361268533 title "KNT-127, a selective delta opioid receptor agonist, shows beneficial effects in the hippocampal dentate gyrus of a chronic vicarious social defeat stress mouse model" @default.
• W4361268533 cites W1505495051 @default.
• W4361268533 cites W1936363685 @default.
• W4361268533 cites W1974776346 @default.
• W4361268533 cites W2003717081 @default.
• W4361268533 cites W2010469304 @default.
• W4361268533 cites W2015667982 @default.
• W4361268533 cites W2023343492 @default.
• W4361268533 cites W2025129891 @default.
• W4361268533 cites W2030772288 @default.
• W4361268533 cites W2041155806 @default.
• W4361268533 cites W2052639257 @default.
• W4361268533 cites W2054315926 @default.
• W4361268533 cites W2055747883 @default.
• W4361268533 cites W2072807884 @default.
• W4361268533 cites W2076615830 @default.
• W4361268533 cites W2089372771 @default.
• W4361268533 cites W2095108407 @default.
• W4361268533 cites W2123487802 @default.
• W4361268533 cites W2148239264 @default.
• W4361268533 cites W2155686640 @default.
• W4361268533 cites W2223515559 @default.
• W4361268533 cites W2259912978 @default.
• W4361268533 cites W2346391128 @default.
• W4361268533 cites W2413515606 @default.
• W4361268533 cites W2537885802 @default.
• W4361268533 cites W2540848933 @default.
• W4361268533 cites W2558153396 @default.
• W4361268533 cites W2559884158 @default.
• W4361268533 cites W2730275538 @default.
• W4361268533 cites W2783953475 @default.
• W4361268533 cites W2791146351 @default.
• W4361268533 cites W2804081205 @default.
• W4361268533 cites W2981537004 @default.
• W4361268533 cites W3040888212 @default.
• W4361268533 cites W3099258589 @default.
• W4361268533 cites W3113705801 @default.
• W4361268533 cites W3128681746 @default.
• W4361268533 cites W3161437743 @default.
• W4361268533 cites W3193516209 @default.
• W4361268533 cites W3199022036 @default.
• W4361268533 cites W4210912546 @default.
• W4361268533 cites W4303191854 @default.
• W4361268533 cites W69500316 @default.
• W4361268533 doi "https://doi.org/10.1016/j.neuropharm.2023.109511" @default.
• W4361268533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37001727" @default.
• W4361268533 hasPublicationYear "2023" @default.
• W4361268533 type Work @default.
• W4361268533 citedByCount "1" @default.
• W4361268533 countsByYear W43612685332023 @default.
• W4361268533 crossrefType "journal-article" @default.
• W4361268533 hasAuthorship W4361268533A5016291372 @default.
• W4361268533 hasAuthorship W4361268533A5029754237 @default.
• W4361268533 hasAuthorship W4361268533A5043346994 @default.
• W4361268533 hasAuthorship W4361268533A5068736197 @default.
• W4361268533 hasAuthorship W4361268533A5084048161 @default.
• W4361268533 hasConcept C126322002 @default.
• W4361268533 hasConcept C134018914 @default.
• W4361268533 hasConcept C136834591 @default.
• W4361268533 hasConcept C148762608 @default.
• W4361268533 hasConcept C15744967 @default.
• W4361268533 hasConcept C169760540 @default.
• W4361268533 hasConcept C170493617 @default.
• W4361268533 hasConcept C2776464000 @default.
• W4361268533 hasConcept C2776914184 @default.
• W4361268533 hasConcept C2777542384 @default.
• W4361268533 hasConcept C2778938600 @default.
• W4361268533 hasConcept C2779760398 @default.
• W4361268533 hasConcept C2780352252 @default.
• W4361268533 hasConcept C2781161787 @default.
• W4361268533 hasConcept C2781176699 @default.
• W4361268533 hasConcept C28328180 @default.
• W4361268533 hasConcept C4746552 @default.
• W4361268533 hasConcept C54355233 @default.
• W4361268533 hasConcept C71315377 @default.
• W4361268533 hasConcept C71924100 @default.
• W4361268533 hasConcept C86803240 @default.
• W4361268533 hasConcept C87753298 @default.
• W4361268533 hasConceptScore W4361268533C126322002 @default.
• W4361268533 hasConceptScore W4361268533C134018914 @default.
• W4361268533 hasConceptScore W4361268533C136834591 @default.
• W4361268533 hasConceptScore W4361268533C148762608 @default.
• W4361268533 hasConceptScore W4361268533C15744967 @default.
• W4361268533 hasConceptScore W4361268533C169760540 @default.
• W4361268533 hasConceptScore W4361268533C170493617 @default.
• W4361268533 hasConceptScore W4361268533C2776464000 @default.
• W4361268533 hasConceptScore W4361268533C2776914184 @default.
• W4361268533 hasConceptScore W4361268533C2777542384 @default.
• W4361268533 hasConceptScore W4361268533C2778938600 @default.

• next