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- W4361268798 endingPage "137215" @default.
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- W4361268798 abstract "Many enteric glia are located along nerve fibers in the gut mucosa where they form close associations with the epithelium lining the gastrointestinal tract. The gut epithelium is essential for absorbing nutrients, regulating fluid flux, forming a physical barrier to prevent the entry of pathogens and toxins into the host, and participating in immune responses. Disruptions to this epithelium are linked to numerous diseases, highlighting its central importance in maintaining health. Accumulating evidence indicates that glia regulate gut epithelial homeostasis. Observations from glial-epithelial co-cultures in vitro and mouse genetic models in vivo suggest that enteric glia influence several important features of the gut epithelium including barrier integrity, ion transport, and capacity for self-renewal. Here we review the evidence for enteric glial regulation of the intestinal epithelium, with a focus on these three features of its biology." @default.
- W4361268798 created "2023-03-31" @default.
- W4361268798 creator A5013440829 @default.
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- W4361268798 date "2023-05-01" @default.
- W4361268798 modified "2023-09-27" @default.
- W4361268798 title "Mini-Review: Enteric glial regulation of the gastrointestinal epithelium" @default.
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- W4361268798 doi "https://doi.org/10.1016/j.neulet.2023.137215" @default.
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