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- W4361269612 abstract "Paired single-cell RNA and T cell receptor sequencing (scRNA/TCR-seq) has allowed for enhanced resolution of clonal T cell dynamics in cancer. Here, we report a scRNA/TCR-seq analysis of 187,650 T cells from 31 tissue regions, including tumor, adjacent normal tissues, and lymph nodes (LN), from three patients with non-small cell lung cancer after immune checkpoint blockade (ICB). Regions with viable cancer cells are enriched for exhausted CD8+ T cells, regulatory CD4+ T cells (Treg), and follicular helper CD4+ T cells (TFH). Tracking T cell clonotypes across tissues, combined with neoantigen specificity assays, reveals that TFH and tumor-specific exhausted CD8+ T cells are clonally linked to TCF7+SELL+ progenitors in tumor draining LNs, and progressive exhaustion trajectories of CD8+ T, Treg, and TFH cells with proximity to the tumor microenvironment. Finally, longitudinal tracking of tumor-specific CD8+ and CD4+ T cell clones reveals persistence in the peripheral blood for years after ICB therapy." @default.
- W4361269612 created "2023-03-31" @default.
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- W4361269612 date "2023-04-01" @default.
- W4361269612 modified "2023-10-18" @default.
- W4361269612 title "Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade" @default.
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- W4361269612 doi "https://doi.org/10.1016/j.ccell.2023.03.009" @default.
- W4361269612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37001526" @default.
- W4361269612 hasPublicationYear "2023" @default.
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