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- W4361274328 endingPage "617" @default.
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- W4361274328 abstract "Despite recent advances in treatment and significant improvements in prognosis, thrombosis remains the major cause of death in systemic lupus erythematosus (SLE). Antiphospholipid antibodies (aPL) are the main triggers of thrombosis in patients with SLE, with a frequency of approximately 30-40%. Lupus anticoagulant, anticardiolipin, and anti-β2-glycoprotein I antibodies, which are included in the criteria for antiphospholipid syndrome, and 'non-criteria' aPL such as anti-phosphatidylserine/prothrombin complex antibodies, are risk factors for thrombosis in patients with SLE. Multiple positivity for aPL is also associated with an increased risk of thrombosis, and scores calculated from aPL profiles can predict the risk of developing thrombosis. Although there is insufficient evidence for treatment, aPL-positive SLE patients should/may be treated with anticoagulants and/or low-dose aspirin as appropriate. This review summarises the evidence on the clinical significance of the aPL profile as a biomarker of thrombophilia in patients with SLE." @default.
- W4361274328 created "2023-03-31" @default.
- W4361274328 creator A5070300954 @default.
- W4361274328 creator A5079071350 @default.
- W4361274328 date "2023-03-30" @default.
- W4361274328 modified "2023-09-26" @default.
- W4361274328 title "An Antiphospholipid Antibody Profile as a Biomarker for Thrombophilia in Systemic Lupus Erythematosus" @default.
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- W4361274328 doi "https://doi.org/10.3390/biom13040617" @default.
- W4361274328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37189365" @default.
- W4361274328 hasPublicationYear "2023" @default.
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