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- W4361275931 abstract "Transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of cellular responses against environmental stresses. NRF2 induces expression of detoxification and antioxidant enzymes and suppresses inductions of pro-inflammatory cytokine genes. KEAP1 (Kelch-like ECH-associated protein 1) is an adaptor subunit of CULLIN 3 (CUL3)-based E3 ubiquitin ligase. KEAP1 regulates the activity of NRF2 and acts as a sensor for oxidative and electrophilic stresses. NRF2 has been found to be activated in many types of cancers with poor prognosis. Therapeutic strategies to control NRF2-overeactivated cancers have been considered not only by targeting cancer cells with NRF2 inhibitors or NRF2 synthetic lethal chemicals, but also by targeting host defense with NRF2 inducers. Understanding precise molecular mechanisms how the KEAP1-NRF2 system senses and regulates the cellular response is critical to overcome intractable NRF2-activated cancers." @default.
- W4361275931 created "2023-03-31" @default.
- W4361275931 creator A5022730948 @default.
- W4361275931 creator A5066933880 @default.
- W4361275931 creator A5067454062 @default.
- W4361275931 date "2023-03-27" @default.
- W4361275931 modified "2023-10-14" @default.
- W4361275931 title "Molecular Basis of the KEAP1-NRF2 Signaling Pathway" @default.
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- W4361275931 doi "https://doi.org/10.14348/molcells.2023.0028" @default.
- W4361275931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36994473" @default.
- W4361275931 hasPublicationYear "2023" @default.
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