FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361276685> ?p ?o ?g. }

• W4361276685 abstract "Neural circuits are characterized as interconnecting neuron networks connected by synapses. Some kinds of gene expression and/or functional changes of neurons and synaptic connections may result in aberrant neural circuits, which has been recognized as one crucial pathological mechanism for the onset of many neurological diseases. Gradual advances in single-cell sequencing approaches with strong technological advantages, as exemplified by high throughput and increased resolution for live cells, have enabled it to assist us in understanding neuronal diversity across diverse brain regions and further transformed our knowledge of cellular building blocks of neural circuits through revealing numerous molecular signatures. Currently published transcriptomic studies have elucidated various neuronal subpopulations as well as their distribution across prefrontal cortex, hippocampus, hypothalamus, and dorsal root ganglion, etc. Better characterization of brain region-specific circuits may shed light on new pathological mechanisms involved and assist in selecting potential targets for the prevention and treatment of specific neurological disorders based on their established roles. Given diverse neuronal populations across different brain regions, we aim to give a brief sketch of current progress in understanding neuronal diversity and neural circuit complexity according to their locations. With the special focus on the application of single-cell sequencing, we thereby summarize relevant region-specific findings. Considering the importance of spatial context and connectivity in neural circuits, we also discuss a few published results obtained by spatial transcriptomics. Taken together, these single-cell sequencing data may lay a mechanistic basis for functional identification of brain circuit components, which links their molecular signatures to anatomical regions, connectivity, morphology, and physiology. Furthermore, the comprehensive characterization of neuron subtypes, their distributions, and connectivity patterns via single-cell sequencing is critical for understanding neural circuit properties and how they generate region-dependent interactions in different context." @default.
• W4361276685 created "2023-03-31" @default.
• W4361276685 creator A5035064408 @default.
• W4361276685 creator A5049264813 @default.
• W4361276685 creator A5069599515 @default.
• W4361276685 date "2023-03-30" @default.
• W4361276685 modified "2023-10-17" @default.
• W4361276685 title "Recent advances in understanding neuronal diversity and neural circuit complexity across different brain regions using single-cell sequencing" @default.
• W4361276685 cites W1580018887 @default.
• W4361276685 cites W1921182138 @default.
• W4361276685 cites W1988391018 @default.
• W4361276685 cites W2033072655 @default.
• W4361276685 cites W2107177404 @default.
• W4361276685 cites W2114139156 @default.
• W4361276685 cites W2149573463 @default.
• W4361276685 cites W2151301539 @default.
• W4361276685 cites W2211603551 @default.
• W4361276685 cites W2218943248 @default.
• W4361276685 cites W2275242227 @default.
• W4361276685 cites W2317009739 @default.
• W4361276685 cites W2520858613 @default.
• W4361276685 cites W2533012945 @default.
• W4361276685 cites W2587025557 @default.
• W4361276685 cites W2601723752 @default.
• W4361276685 cites W2609473806 @default.
• W4361276685 cites W2615702226 @default.
• W4361276685 cites W2744040456 @default.
• W4361276685 cites W2751012569 @default.
• W4361276685 cites W2756729688 @default.
• W4361276685 cites W2763051133 @default.
• W4361276685 cites W2763776271 @default.
• W4361276685 cites W2769455647 @default.
• W4361276685 cites W2773035279 @default.
• W4361276685 cites W2775159358 @default.
• W4361276685 cites W2775417722 @default.
• W4361276685 cites W2785373704 @default.
• W4361276685 cites W2791731597 @default.
• W4361276685 cites W2792073521 @default.
• W4361276685 cites W2794083495 @default.
• W4361276685 cites W2800294157 @default.
• W4361276685 cites W2801175520 @default.
• W4361276685 cites W2801611143 @default.
• W4361276685 cites W2802834681 @default.
• W4361276685 cites W2809368942 @default.
• W4361276685 cites W2817838603 @default.
• W4361276685 cites W2886347923 @default.
• W4361276685 cites W2899224111 @default.
• W4361276685 cites W2907389933 @default.
• W4361276685 cites W2913704866 @default.
• W4361276685 cites W2915848182 @default.
• W4361276685 cites W2923300855 @default.
• W4361276685 cites W2937443931 @default.
• W4361276685 cites W2945129130 @default.
• W4361276685 cites W2946232537 @default.
• W4361276685 cites W2950976066 @default.
• W4361276685 cites W2951890476 @default.
• W4361276685 cites W2969948459 @default.
• W4361276685 cites W2972278117 @default.
• W4361276685 cites W2972445800 @default.
• W4361276685 cites W2979142892 @default.
• W4361276685 cites W2979330517 @default.
• W4361276685 cites W2979981663 @default.
• W4361276685 cites W2980307910 @default.
• W4361276685 cites W2981201615 @default.
• W4361276685 cites W2982403397 @default.
• W4361276685 cites W2982565160 @default.
• W4361276685 cites W3000213219 @default.
• W4361276685 cites W3000250187 @default.
• W4361276685 cites W3003005029 @default.
• W4361276685 cites W3004684499 @default.
• W4361276685 cites W3010966623 @default.
• W4361276685 cites W3015712098 @default.
• W4361276685 cites W3021638720 @default.
• W4361276685 cites W3027926441 @default.
• W4361276685 cites W3033567637 @default.
• W4361276685 cites W3033654468 @default.
• W4361276685 cites W3035378275 @default.
• W4361276685 cites W3087581477 @default.
• W4361276685 cites W3089778110 @default.
• W4361276685 cites W3093189548 @default.
• W4361276685 cites W3094668538 @default.
• W4361276685 cites W3109313267 @default.
• W4361276685 cites W3110844623 @default.
• W4361276685 cites W3111826110 @default.
• W4361276685 cites W3119521568 @default.
• W4361276685 cites W3120694378 @default.
• W4361276685 cites W3126958162 @default.
• W4361276685 cites W3128953197 @default.
• W4361276685 cites W3129495705 @default.
• W4361276685 cites W3134111171 @default.
• W4361276685 cites W3138542279 @default.
• W4361276685 cites W3162190779 @default.
• W4361276685 cites W3162218953 @default.
• W4361276685 cites W3181062831 @default.
• W4361276685 cites W3193447308 @default.
• W4361276685 cites W3194502243 @default.
• W4361276685 cites W3197839114 @default.
• W4361276685 cites W3202358235 @default.
• W4361276685 cites W3202416243 @default.
• W4361276685 cites W3203364159 @default.

• next