Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361279175> ?p ?o ?g. }
- W4361279175 endingPage "6433" @default.
- W4361279175 startingPage "6433" @default.
- W4361279175 abstract "Traumatic spinal cord injury (SCI) initiates a cascade of cellular events, culminating in irreversible tissue loss and neuroinflammation. After the trauma, the blood vessels are destroyed. The blood-spinal cord barrier (BSCB), a physical barrier between the blood and spinal cord parenchyma, is disrupted, facilitating the infiltration of immune cells, and contributing to a toxic spinal microenvironment, affecting axonal regeneration. Understanding how the vascular constituents of the BSCB respond to injury is crucial to prevent BSCB impairment and to improve spinal cord repair. Here, we focus our attention on the vascular transcriptome at 3- and 7-days post-injury (dpi), during which BSCB is abnormally leaky, to identify potential molecular players that are injury-specific. Using the mouse contusion model, we identified Cd9 and Mylip genes as differentially expressed at 3 and 7 dpi. CD9 and MYLIP expression were injury-induced on vascular cells, endothelial cells and pericytes, at the injury epicentre at 7 dpi, with a spatial expression predominantly at the caudal region of the lesion. These results establish CD9 and MYLIP as two new potential players after SCI, and future studies targeting their expression might bring promising results for spinal cord repair." @default.
- W4361279175 created "2023-03-31" @default.
- W4361279175 creator A5006220828 @default.
- W4361279175 creator A5009652768 @default.
- W4361279175 creator A5014188493 @default.
- W4361279175 creator A5015785527 @default.
- W4361279175 creator A5023719189 @default.
- W4361279175 creator A5024177947 @default.
- W4361279175 creator A5031445150 @default.
- W4361279175 creator A5035463673 @default.
- W4361279175 creator A5056580072 @default.
- W4361279175 creator A5082021183 @default.
- W4361279175 date "2023-03-29" @default.
- W4361279175 modified "2023-10-09" @default.
- W4361279175 title "Mouse Spinal Cord Vascular Transcriptome Analysis Identifies CD9 and MYLIP as Injury-Induced Players" @default.
- W4361279175 cites W1771341671 @default.
- W4361279175 cites W1953973432 @default.
- W4361279175 cites W1957500455 @default.
- W4361279175 cites W2001657855 @default.
- W4361279175 cites W2035618305 @default.
- W4361279175 cites W2047585900 @default.
- W4361279175 cites W2056319562 @default.
- W4361279175 cites W2067723708 @default.
- W4361279175 cites W2068767807 @default.
- W4361279175 cites W2087356761 @default.
- W4361279175 cites W2107967984 @default.
- W4361279175 cites W2114104545 @default.
- W4361279175 cites W2115390024 @default.
- W4361279175 cites W2119303378 @default.
- W4361279175 cites W2130410032 @default.
- W4361279175 cites W2139480055 @default.
- W4361279175 cites W2141244009 @default.
- W4361279175 cites W2146512944 @default.
- W4361279175 cites W2149412729 @default.
- W4361279175 cites W2156757115 @default.
- W4361279175 cites W2284184435 @default.
- W4361279175 cites W2432815617 @default.
- W4361279175 cites W2611542292 @default.
- W4361279175 cites W2734575704 @default.
- W4361279175 cites W2736485888 @default.
- W4361279175 cites W2751663599 @default.
- W4361279175 cites W2792925567 @default.
- W4361279175 cites W2793340589 @default.
- W4361279175 cites W2794351872 @default.
- W4361279175 cites W2799421001 @default.
- W4361279175 cites W2800787044 @default.
- W4361279175 cites W2924590879 @default.
- W4361279175 cites W2942610007 @default.
- W4361279175 cites W2949693884 @default.
- W4361279175 cites W2970959902 @default.
- W4361279175 cites W2997240122 @default.
- W4361279175 cites W3036646279 @default.
- W4361279175 cites W3111030686 @default.
- W4361279175 cites W3137120028 @default.
- W4361279175 cites W3157468183 @default.
- W4361279175 cites W3163299108 @default.
- W4361279175 cites W3192976125 @default.
- W4361279175 cites W3215192802 @default.
- W4361279175 cites W4303628269 @default.
- W4361279175 doi "https://doi.org/10.3390/ijms24076433" @default.
- W4361279175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37047406" @default.
- W4361279175 hasPublicationYear "2023" @default.
- W4361279175 type Work @default.
- W4361279175 citedByCount "0" @default.
- W4361279175 crossrefType "journal-article" @default.
- W4361279175 hasAuthorship W4361279175A5006220828 @default.
- W4361279175 hasAuthorship W4361279175A5009652768 @default.
- W4361279175 hasAuthorship W4361279175A5014188493 @default.
- W4361279175 hasAuthorship W4361279175A5015785527 @default.
- W4361279175 hasAuthorship W4361279175A5023719189 @default.
- W4361279175 hasAuthorship W4361279175A5024177947 @default.
- W4361279175 hasAuthorship W4361279175A5031445150 @default.
- W4361279175 hasAuthorship W4361279175A5035463673 @default.
- W4361279175 hasAuthorship W4361279175A5056580072 @default.
- W4361279175 hasAuthorship W4361279175A5082021183 @default.
- W4361279175 hasBestOaLocation W43612791751 @default.
- W4361279175 hasConcept C104317684 @default.
- W4361279175 hasConcept C121332964 @default.
- W4361279175 hasConcept C142724271 @default.
- W4361279175 hasConcept C150194340 @default.
- W4361279175 hasConcept C153400128 @default.
- W4361279175 hasConcept C162317418 @default.
- W4361279175 hasConcept C169760540 @default.
- W4361279175 hasConcept C203014093 @default.
- W4361279175 hasConcept C2776914184 @default.
- W4361279175 hasConcept C2778334475 @default.
- W4361279175 hasConcept C2780775167 @default.
- W4361279175 hasConcept C55493867 @default.
- W4361279175 hasConcept C71924100 @default.
- W4361279175 hasConcept C86803240 @default.
- W4361279175 hasConcept C87753298 @default.
- W4361279175 hasConcept C95444343 @default.
- W4361279175 hasConcept C97355855 @default.
- W4361279175 hasConceptScore W4361279175C104317684 @default.
- W4361279175 hasConceptScore W4361279175C121332964 @default.
- W4361279175 hasConceptScore W4361279175C142724271 @default.
- W4361279175 hasConceptScore W4361279175C150194340 @default.
- W4361279175 hasConceptScore W4361279175C153400128 @default.