Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361279503> ?p ?o ?g. }
- W4361279503 abstract "Perivascular spaces have been involved in neuroinflammatory and neurodegenerative diseases. Upon a certain size, these spaces can become visible on magnetic resonance imaging (MRI), referred to as enlarged perivascular spaces (EPVS) or MRI-visible perivascular spaces (MVPVS). However, the lack of systematic evidence on etiology and temporal dynamics of MVPVS hampers their diagnostic utility as MRI biomarker. Thus, the goal of this systematic review was to summarize potential etiologies and evolution of MVPVS.In a comprehensive literature search, out of 1,488 unique publications, 140 records assessing etiopathogenesis and dynamics of MVPVS were eligible for a qualitative summary. 6 records were included in a meta-analysis to assess the association between MVPVS and brain atrophy.Four overarching and partly overlapping etiologies of MVPVS have been proposed: (1) Impairment of interstitial fluid circulation, (2) Spiral elongation of arteries, (3) Brain atrophy and/or perivascular myelin loss, and (4) Immune cell accumulation in the perivascular space. The meta-analysis in patients with neuroinflammatory diseases did not support an association between MVPVS and brain volume measures [R: -0.15 (95%-CI -0.40-0.11)]. Based on few and mostly small studies in tumefactive MVPVS and in vascular and neuroinflammatory diseases, temporal evolution of MVPVS is slow.Collectively, this study provides high-grade evidence for MVPVS etiopathogenesis and temporal dynamics. Although several potential etiologies for MVPVS emergence have been proposed, they are only partially supported by data. Advanced MRI methods should be employed to further dissect etiopathogenesis and evolution of MVPVS. This can benefit their implementation as an imaging biomarker.https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=346564, identifier CRD42022346564." @default.
- W4361279503 created "2023-03-31" @default.
- W4361279503 creator A5023522998 @default.
- W4361279503 creator A5024904743 @default.
- W4361279503 creator A5036989840 @default.
- W4361279503 creator A5037974362 @default.
- W4361279503 creator A5088696166 @default.
- W4361279503 creator A5089479137 @default.
- W4361279503 date "2023-03-30" @default.
- W4361279503 modified "2023-10-14" @default.
- W4361279503 title "The etiology and evolution of magnetic resonance imaging-visible perivascular spaces: Systematic review and meta-analysis" @default.
- W4361279503 cites W1731947656 @default.
- W4361279503 cites W1847115864 @default.
- W4361279503 cites W1891275126 @default.
- W4361279503 cites W1908747898 @default.
- W4361279503 cites W1965080574 @default.
- W4361279503 cites W1967690753 @default.
- W4361279503 cites W1978506065 @default.
- W4361279503 cites W1978636950 @default.
- W4361279503 cites W1982062518 @default.
- W4361279503 cites W1983818246 @default.
- W4361279503 cites W1989179574 @default.
- W4361279503 cites W1996470432 @default.
- W4361279503 cites W2023114245 @default.
- W4361279503 cites W2023227192 @default.
- W4361279503 cites W2024955728 @default.
- W4361279503 cites W2035449167 @default.
- W4361279503 cites W2041807904 @default.
- W4361279503 cites W2045642447 @default.
- W4361279503 cites W2056521898 @default.
- W4361279503 cites W2063341227 @default.
- W4361279503 cites W2072602970 @default.
- W4361279503 cites W2072994130 @default.
- W4361279503 cites W2080567909 @default.
- W4361279503 cites W2100314515 @default.
- W4361279503 cites W2106849104 @default.
- W4361279503 cites W2107143655 @default.
- W4361279503 cites W2107328434 @default.
- W4361279503 cites W2111713854 @default.
- W4361279503 cites W2115505196 @default.
- W4361279503 cites W2117844350 @default.
- W4361279503 cites W2119527709 @default.
- W4361279503 cites W2122481791 @default.
- W4361279503 cites W2123360271 @default.
- W4361279503 cites W2124127780 @default.
- W4361279503 cites W2126930838 @default.
- W4361279503 cites W2130256616 @default.
- W4361279503 cites W2133656070 @default.
- W4361279503 cites W2134532802 @default.
- W4361279503 cites W2137649440 @default.
- W4361279503 cites W2140621953 @default.
- W4361279503 cites W2141408327 @default.
- W4361279503 cites W2149722331 @default.
- W4361279503 cites W2150563896 @default.
- W4361279503 cites W2151380782 @default.
- W4361279503 cites W2153618231 @default.
- W4361279503 cites W2154156502 @default.
- W4361279503 cites W2158742097 @default.
- W4361279503 cites W2161374186 @default.
- W4361279503 cites W2232845926 @default.
- W4361279503 cites W2277338806 @default.
- W4361279503 cites W2289333406 @default.
- W4361279503 cites W2294863901 @default.
- W4361279503 cites W2315123323 @default.
- W4361279503 cites W2321286752 @default.
- W4361279503 cites W2323566945 @default.
- W4361279503 cites W2326264490 @default.
- W4361279503 cites W2417273440 @default.
- W4361279503 cites W2474789764 @default.
- W4361279503 cites W2508411348 @default.
- W4361279503 cites W2514679678 @default.
- W4361279503 cites W2551398945 @default.
- W4361279503 cites W2560438049 @default.
- W4361279503 cites W2568031700 @default.
- W4361279503 cites W2588487507 @default.
- W4361279503 cites W2590987049 @default.
- W4361279503 cites W2602043626 @default.
- W4361279503 cites W2609254407 @default.
- W4361279503 cites W2617019071 @default.
- W4361279503 cites W2731876108 @default.
- W4361279503 cites W2745023142 @default.
- W4361279503 cites W2750730801 @default.
- W4361279503 cites W2766690574 @default.
- W4361279503 cites W2772280415 @default.
- W4361279503 cites W2773303507 @default.
- W4361279503 cites W2793407983 @default.
- W4361279503 cites W2801199684 @default.
- W4361279503 cites W2889250171 @default.
- W4361279503 cites W2897673018 @default.
- W4361279503 cites W2905180587 @default.
- W4361279503 cites W2914584287 @default.
- W4361279503 cites W2921966597 @default.
- W4361279503 cites W2944504351 @default.
- W4361279503 cites W2952584877 @default.
- W4361279503 cites W2965533213 @default.
- W4361279503 cites W2966401005 @default.
- W4361279503 cites W2970100807 @default.
- W4361279503 cites W2998867263 @default.
- W4361279503 cites W3004007615 @default.
- W4361279503 cites W3007815224 @default.