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- W4361279560 endingPage "102710" @default.
- W4361279560 startingPage "102710" @default.
- W4361279560 abstract "Comparative studies of hominids have long sought to identify mutational events that shaped the evolution of the human nervous system. However, functional genetic differences are outnumbered by millions of nearly neutral mutations, and the developmental mechanisms underlying human nervous system specializations are difficult to model and incompletely understood. Candidate-gene studies have attempted to map select human-specific genetic differences to neurodevelopmental functions, but it remains unclear how to contextualize the relative effects of genes that are investigated independently. Considering these limitations, we discuss scalable approaches for probing the functional contributions of human-specific genetic differences. We propose that a systems-level view will enable a more quantitative and integrative understanding of the genetic, molecular and cellular underpinnings of human nervous system evolution." @default.
- W4361279560 created "2023-03-31" @default.
- W4361279560 creator A5060172577 @default.
- W4361279560 creator A5081150118 @default.
- W4361279560 date "2023-06-01" @default.
- W4361279560 modified "2023-10-05" @default.
- W4361279560 title "Genetic architecture of human brain evolution" @default.
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- W4361279560 doi "https://doi.org/10.1016/j.conb.2023.102710" @default.
- W4361279560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37003107" @default.