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- W4361279804 abstract "<ns4:p><ns4:bold>Background:</ns4:bold> Tigecycline (TGC) is a recently developed antibiotic to battle resistant bacteria. The procedures outlined in the literature for analyzing TGC involve chemical solvents that could be hazardous. Therefore, this study aimed to create a sustainable and stable HPLC technique for quantifying Tigecycline in lyophilized powder. The powerful chemometric tool, experimental design (ED), will be applied to analyze the variables' interaction and impact on the selected analytical target profiles. Response surface methodology provides a tutorial on using the central composite design with three levels of variables and quadratic programming to optimize the design space of the developed method.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> The New HPLC method consisted of an aqueous buffer and ethanol as a green mobile phase run on a reversed-phase symmetry C18 column. A full resolution between the Tigecycline and its degradation product peaks was achieved in a short analytical runtime.</ns4:p><ns4:p> <ns4:bold>Results:</ns4:bold> Further, the specificity, accuracy, precision, robustness and stability indicating power of the proposed approach were verified through stress degrading testing.</ns4:p><ns4:p> <ns4:bold>Conclusions:</ns4:bold> Finally, the analytical eco-scale and the green Analytical Procedure Index (GAPI) were utilized to determine how environmentally friendly the recommended method was compared to other published approaches.</ns4:p>" @default.
- W4361279804 created "2023-03-31" @default.
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- W4361279804 date "2023-03-28" @default.
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- W4361279804 title "Central composite design driven optimization of sustainable stability indicating HPLC method for the determination of Tigecycline and greenness assessment" @default.
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- W4361279804 doi "https://doi.org/10.12688/f1000research.130861.1" @default.
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