FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361280882> ?p ?o ?g. }

• W4361280882 abstract "Background Gynecological cancers are the most lethal malignancies among females, most of which are associated with gene mutations. Few studies have compared the differences in the genomic landscape among various types of gynecological cancers. In this study, we evaluated the diversity of mutations in different gynecological cancers. Methods A total of 184 patients with gynecological cancer, including ovarian, cervical, fallopian tube, and endometrial cancer, were included. Next-generation sequencing was performed to detect the mutations and tumor mutational burden (TMB). Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses were also conducted. Results We found that 94.57% of patients had at least one mutation, among which single nucleotide variants, insertions and InDels were in the majority. TP53, PIK3CA, PTEN, KRAS, BRCA1, BRCA2, ARID1A, KMT2C, FGFR2 , and FGFR3 were the top 10 most frequently mutated genes. Patients with ovarian cancer tended to have higher frequencies of BRCA1 and BRCA2 mutations, and the frequency of germline BRCA1 mutations (18/24, 75.00%) was higher than that of BRCA2 (11/19, 57.89%). A new mutation hotspot in BRCA2 (I770) was firstly discovered among Chinese patients with gynecological cancer. Patients with TP53 , PIK3CA , PTEN , and FGFR3 mutations had significantly higher TMB values than those with wild-type genes. A significant cross was discovered between the enriched KEGG pathways of gynecological and breast cancers. GO enrichment revealed that the mutated genes were crucial for the cell cycle, neuronal apoptosis, and DNA repair. Conclusion Various gynecological cancer types share similarities and differences both in clinical characterization and genomic mutations. Taken together with the results of TMB and enriched pathways, this study provided useful information on the molecular mechanism underlying gynecological cancers and the development of targeted drugs and precision medicine." @default.
• W4361280882 created "2023-03-31" @default.
• W4361280882 creator A5002656825 @default.
• W4361280882 creator A5006942799 @default.
• W4361280882 creator A5015860750 @default.
• W4361280882 creator A5018713975 @default.
• W4361280882 creator A5021925661 @default.
• W4361280882 creator A5025325761 @default.
• W4361280882 creator A5042041170 @default.
• W4361280882 date "2023-03-30" @default.
• W4361280882 modified "2023-10-14" @default.
• W4361280882 title "Clinical characterization and genomic landscape of gynecological cancers among patients attending a Chinese hospital" @default.
• W4361280882 cites W1984068087 @default.
• W4361280882 cites W2055294836 @default.
• W4361280882 cites W2064354484 @default.
• W4361280882 cites W2102004732 @default.
• W4361280882 cites W2110790489 @default.
• W4361280882 cites W2123696077 @default.
• W4361280882 cites W2126633009 @default.
• W4361280882 cites W2155191323 @default.
• W4361280882 cites W2323851578 @default.
• W4361280882 cites W2557981253 @default.
• W4361280882 cites W2606495925 @default.
• W4361280882 cites W2737389832 @default.
• W4361280882 cites W2766848342 @default.
• W4361280882 cites W2779221466 @default.
• W4361280882 cites W2791963911 @default.
• W4361280882 cites W2796612976 @default.
• W4361280882 cites W2909679049 @default.
• W4361280882 cites W2911915301 @default.
• W4361280882 cites W2961813874 @default.
• W4361280882 cites W2965204233 @default.
• W4361280882 cites W3005699106 @default.
• W4361280882 cites W3031364557 @default.
• W4361280882 cites W3069478358 @default.
• W4361280882 cites W3092045953 @default.
• W4361280882 cites W3110580349 @default.
• W4361280882 cites W3119005666 @default.
• W4361280882 cites W3126444173 @default.
• W4361280882 cites W3128646645 @default.
• W4361280882 cites W3134955960 @default.
• W4361280882 cites W3215335387 @default.
• W4361280882 cites W4205568747 @default.
• W4361280882 cites W4206755966 @default.
• W4361280882 cites W4206841660 @default.
• W4361280882 cites W4210315289 @default.
• W4361280882 cites W4211097225 @default.
• W4361280882 cites W4220984610 @default.
• W4361280882 cites W4224312038 @default.
• W4361280882 cites W4224943718 @default.
• W4361280882 cites W4236289131 @default.
• W4361280882 cites W4283797984 @default.
• W4361280882 cites W4288439140 @default.
• W4361280882 cites W4289519854 @default.
• W4361280882 cites W4290614483 @default.
• W4361280882 cites W4290995081 @default.
• W4361280882 cites W4292546361 @default.
• W4361280882 cites W4293221076 @default.
• W4361280882 cites W4293827129 @default.
• W4361280882 cites W4304004523 @default.
• W4361280882 cites W4308124616 @default.
• W4361280882 cites W4308206076 @default.
• W4361280882 cites W4308354281 @default.
• W4361280882 cites W4308679301 @default.
• W4361280882 cites W4308741689 @default.
• W4361280882 cites W4308877633 @default.
• W4361280882 cites W4309470034 @default.
• W4361280882 cites W4309657301 @default.
• W4361280882 doi "https://doi.org/10.3389/fonc.2023.1143876" @default.
• W4361280882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37064128" @default.
• W4361280882 hasPublicationYear "2023" @default.
• W4361280882 type Work @default.
• W4361280882 citedByCount "0" @default.
• W4361280882 crossrefType "journal-article" @default.
• W4361280882 hasAuthorship W4361280882A5002656825 @default.
• W4361280882 hasAuthorship W4361280882A5006942799 @default.
• W4361280882 hasAuthorship W4361280882A5015860750 @default.
• W4361280882 hasAuthorship W4361280882A5018713975 @default.
• W4361280882 hasAuthorship W4361280882A5021925661 @default.
• W4361280882 hasAuthorship W4361280882A5025325761 @default.
• W4361280882 hasAuthorship W4361280882A5042041170 @default.
• W4361280882 hasBestOaLocation W43612808821 @default.
• W4361280882 hasConcept C104317684 @default.
• W4361280882 hasConcept C121608353 @default.
• W4361280882 hasConcept C126322002 @default.
• W4361280882 hasConcept C13514818 @default.
• W4361280882 hasConcept C143998085 @default.
• W4361280882 hasConcept C150194340 @default.
• W4361280882 hasConcept C152724338 @default.
• W4361280882 hasConcept C190283241 @default.
• W4361280882 hasConcept C2777088508 @default.
• W4361280882 hasConcept C2777609662 @default.
• W4361280882 hasConcept C2780427987 @default.
• W4361280882 hasConcept C2781187634 @default.
• W4361280882 hasConcept C2987395477 @default.
• W4361280882 hasConcept C501734568 @default.
• W4361280882 hasConcept C502942594 @default.
• W4361280882 hasConcept C54355233 @default.
• W4361280882 hasConcept C71924100 @default.
• W4361280882 hasConcept C86554907 @default.

• next