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• W4361285462 endingPage "188886" @default.
• W4361285462 startingPage "188886" @default.
• W4361285462 abstract "The classical role of C-terminal binding protein (CtBP) is that of a global corepressor. However, its exact mechanism of repression is not known. In this review, we elucidate the repression motif used by CtBP. Further, we provide other unifying features of its mechanism of action. For example, in the presence of a high NADH/NAD+ ratio in the cell, causing a low glycolytic condition, the NADH-bound dimeric form of CtBP causes global repression, maintaining balances and homeostases of many cellular processes, under the cell surveillance of p53 and NFkB. In contrast, in the presence of a low NADH/NAD+ ratio, causing a high glycolytic condition, the NADH-free monomeric form of CtBP blocks p53 function and NFkB-mediated transcription. Further, a low NADH/NAD+ ratio upsets the homeostases and balances in the absence of the cell surveillances of p53 and NFkB, causing global instability, the dominant outcome of CtBP's action in carcinogenesis, in cells in a high glycolytic state." @default.
• W4361285462 created "2023-03-31" @default.
• W4361285462 creator A5051647512 @default.
• W4361285462 creator A5066685187 @default.
• W4361285462 date "2023-05-01" @default.
• W4361285462 modified "2023-09-29" @default.
• W4361285462 title "CtBP: A global regulator of balancing acts and homeostases" @default.
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• W4361285462 doi "https://doi.org/10.1016/j.bbcan.2023.188886" @default.
• W4361285462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37001619" @default.
• W4361285462 hasPublicationYear "2023" @default.
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