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- W4361288596 abstract "Nano-engineering-based tissue regeneration and local therapeutic delivery strategies show significant potential to reduce the health and economic burden associated with craniofacial defects, including traumas and tumours. Critical to the success of such nano-engineered non-resorbable craniofacial implants include load-bearing functioning and survival in complex local trauma conditions. Further, race to invade between multiple cells and pathogens is an important criterion that dictates the fate of the implant. In this pioneering review, we compare the therapeutic efficacy of nano-engineered titanium-based craniofacial implants towards maximised local therapy addressing bone formation/resorption, soft-tissue integration, bacterial infection and cancers/tumours. We present the various strategies to engineer titanium-based craniofacial implants in the macro-, micro- and nano-scales, using topographical, chemical, electrochemical, biological and therapeutic modifications. A particular focus is electrochemically anodised titanium implants with controlled nanotopographies that enable tailored and enhanced bioactivity and local therapeutic release. Next, we review the clinical translation challenges associated with such implants. This review will inform the readers of the latest developments and challenges related to therapeutic nano-engineered craniofacial implants." @default.
- W4361288596 created "2023-03-31" @default.
- W4361288596 creator A5001092385 @default.
- W4361288596 creator A5010914569 @default.
- W4361288596 creator A5040391486 @default.
- W4361288596 creator A5079306986 @default.
- W4361288596 creator A5089487479 @default.
- W4361288596 creator A5043124778 @default.
- W4361288596 date "2023-03-29" @default.
- W4361288596 modified "2023-10-10" @default.
- W4361288596 title "Craniofacial therapy: advanced local therapies from nano-engineered titanium implants to treat craniofacial conditions" @default.
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