FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361289325> ?p ?o ?g. }

• W4361289325 endingPage "791" @default.
• W4361289325 startingPage "780" @default.
• W4361289325 abstract "Loss-of-function mutations in the contactin-associated protein-like 2 (CNTNAP2) gene are causal for neurodevelopmental disorders, including autism, schizophrenia, epilepsy, and intellectual disability. CNTNAP2 encodes CASPR2, a single-pass transmembrane protein that belongs to the neurexin family of cell adhesion molecules. These proteins have a variety of functions in developing neurons, including connecting presynaptic and postsynaptic neurons, and mediating signaling across the synapse.To study the effect of loss of CNTNAP2 function on human cerebral cortex development, and how this contributes to the pathogenesis of neurodevelopmental disorders, we generated human induced pluripotent stem cells from one neurotypical control donor null for full-length CNTNAP2, modeling cortical development from neurogenesis through to neural network formation in vitro.CNTNAP2 is particularly highly expressed in the first two populations of early-born excitatory cortical neurons, and loss of CNTNAP2 shifted the relative proportions of these two neuronal types. Live imaging of excitatory neuronal growth showed that loss of CNTNAP2 reduced neurite branching and overall neuronal complexity. At the network level, developing cortical excitatory networks null for CNTNAP2 had complex changes in activity compared with isogenic controls: an initial period of relatively reduced activity compared with isogenic controls, followed by a lengthy period of hyperexcitability, and then a further switch to reduced activity.Complete loss of CNTNAP2 contributes to the pathogenesis of neurodevelopmental disorders through complex changes in several aspects of human cerebral cortex excitatory neuron development that culminate in aberrant neural network formation and function." @default.
• W4361289325 created "2023-03-31" @default.
• W4361289325 creator A5038295024 @default.
• W4361289325 creator A5055846946 @default.
• W4361289325 creator A5086843415 @default.
• W4361289325 creator A5088297719 @default.
• W4361289325 date "2023-11-01" @default.
• W4361289325 modified "2023-10-18" @default.
• W4361289325 title "Loss of CNTNAP2 Alters Human Cortical Excitatory Neuron Differentiation and Neural Network Development" @default.
• W4361289325 cites W1590571258 @default.
• W4361289325 cites W1895793456 @default.
• W4361289325 cites W1926834468 @default.
• W4361289325 cites W1967551107 @default.
• W4361289325 cites W1983927922 @default.
• W4361289325 cites W1986561232 @default.
• W4361289325 cites W1995809507 @default.
• W4361289325 cites W2002938212 @default.
• W4361289325 cites W2003479128 @default.
• W4361289325 cites W2003493421 @default.
• W4361289325 cites W2003895747 @default.
• W4361289325 cites W2004091189 @default.
• W4361289325 cites W2004104083 @default.
• W4361289325 cites W2008324609 @default.
• W4361289325 cites W2017110893 @default.
• W4361289325 cites W2022498096 @default.
• W4361289325 cites W2023652080 @default.
• W4361289325 cites W2035310577 @default.
• W4361289325 cites W2035473823 @default.
• W4361289325 cites W2035660891 @default.
• W4361289325 cites W2045233900 @default.
• W4361289325 cites W2047534565 @default.
• W4361289325 cites W2052628586 @default.
• W4361289325 cites W2054962059 @default.
• W4361289325 cites W2059284774 @default.
• W4361289325 cites W2072374906 @default.
• W4361289325 cites W2072577103 @default.
• W4361289325 cites W2076154138 @default.
• W4361289325 cites W2081905878 @default.
• W4361289325 cites W2082314612 @default.
• W4361289325 cites W2088714934 @default.
• W4361289325 cites W2094421200 @default.
• W4361289325 cites W2100242214 @default.
• W4361289325 cites W2108994842 @default.
• W4361289325 cites W2110747892 @default.
• W4361289325 cites W2113126716 @default.
• W4361289325 cites W2118922889 @default.
• W4361289325 cites W2122971055 @default.
• W4361289325 cites W2126538155 @default.
• W4361289325 cites W2127753140 @default.
• W4361289325 cites W2135494416 @default.
• W4361289325 cites W2146406135 @default.
• W4361289325 cites W2150428478 @default.
• W4361289325 cites W2152704739 @default.
• W4361289325 cites W2161984003 @default.
• W4361289325 cites W2163302580 @default.
• W4361289325 cites W2168257805 @default.
• W4361289325 cites W2179438025 @default.
• W4361289325 cites W2194016361 @default.
• W4361289325 cites W2195294260 @default.
• W4361289325 cites W2298842603 @default.
• W4361289325 cites W2477731606 @default.
• W4361289325 cites W2521106965 @default.
• W4361289325 cites W2625523848 @default.
• W4361289325 cites W2754702491 @default.
• W4361289325 cites W2785085486 @default.
• W4361289325 cites W2794389439 @default.
• W4361289325 cites W2795965187 @default.
• W4361289325 cites W2803940603 @default.
• W4361289325 cites W2809625933 @default.
• W4361289325 cites W2913173993 @default.
• W4361289325 cites W2915067238 @default.
• W4361289325 cites W2935717734 @default.
• W4361289325 cites W2946016273 @default.
• W4361289325 cites W2950040155 @default.
• W4361289325 cites W2951799803 @default.
• W4361289325 cites W2952701408 @default.
• W4361289325 cites W2953198218 @default.
• W4361289325 cites W2976579916 @default.
• W4361289325 cites W2981973079 @default.
• W4361289325 cites W3001393877 @default.
• W4361289325 cites W3034168806 @default.
• W4361289325 cites W3207129859 @default.
• W4361289325 cites W4200501226 @default.
• W4361289325 doi "https://doi.org/10.1016/j.biopsych.2023.03.014" @default.
• W4361289325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37001843" @default.
• W4361289325 hasPublicationYear "2023" @default.
• W4361289325 type Work @default.
• W4361289325 citedByCount "1" @default.
• W4361289325 countsByYear W43612893252023 @default.
• W4361289325 crossrefType "journal-article" @default.
• W4361289325 hasAuthorship W4361289325A5038295024 @default.
• W4361289325 hasAuthorship W4361289325A5055846946 @default.
• W4361289325 hasAuthorship W4361289325A5086843415 @default.
• W4361289325 hasAuthorship W4361289325A5088297719 @default.
• W4361289325 hasBestOaLocation W43612893251 @default.
• W4361289325 hasConcept C104317684 @default.
• W4361289325 hasConcept C112592302 @default.
• W4361289325 hasConcept C127445978 @default.

• next