FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361291277> ?p ?o ?g. }

• W4361291277 abstract "Inflammatory bowel disease (IBD) is an idiopathic chronic inflammatory bowel disease characterized by inflammation, intestinal barrier injury, and imbalance of gut microbiota. Excess accumulation of reactive oxygen species (ROS) is closely correlated with the development and reoccurrence of IBD. Previous researches demonstrate that procyanidin, as a natural antioxidant, exhibits strong ability of eliminating ROS, thus showing good therapeutic effects in the inflammation-related diseases. Non-etheless, its poor stability and solubility always limits the therapeutic outcomes. Here, we typically designed an antioxidant coordination polymer nanoparticle using the engineering of procyanidin (Pc) and free iron (Fe), named Pc-Fe nanozyme, for effectively scavenging ROS and further inhibiting inflammation while altering the gut microbiome for the treatment of colitis. Furthermore, in vitro experiments uncover that Pc-Fe nanoparticles exert strong multi biomimic activities, including peroxidase, and glutathione peroxidase, for the scavenging of ROS and protecting cells from oxidative injury. In addition, the colon accumulation of Pc-Fe nanozyme effectively protects the intestinal mucosa from oxidative damage while significantly downregulates pro-inflammatory factors, repairs the intestinal barriers and alternates gut microbiome after orally administrated in sodium dextran sulfate (DSS) induced colitis mice. The results collectively illustrate that the multienzyme mimicking Pc-Fe nanozyme owns high potential for treating IBD through scavenging ROS, inhibiting inflammation, repairing gut barriers and alternating gut microbiome, which further promising its clinical translation on IBD treatment and other ROS induced intestinal diseases." @default.
• W4361291277 created "2023-03-31" @default.
• W4361291277 creator A5016607883 @default.
• W4361291277 creator A5022504184 @default.
• W4361291277 creator A5035210772 @default.
• W4361291277 creator A5035217108 @default.
• W4361291277 creator A5036069633 @default.
• W4361291277 creator A5069331768 @default.
• W4361291277 creator A5072720203 @default.
• W4361291277 date "2023-03-29" @default.
• W4361291277 modified "2023-09-26" @default.
• W4361291277 title "Engineered procyanidin-Fe nanoparticle alleviates intestinal inflammation through scavenging ROS and altering gut microbiome in colitis mice" @default.
• W4361291277 cites W1504737472 @default.
• W4361291277 cites W1596258860 @default.
• W4361291277 cites W1965664324 @default.
• W4361291277 cites W1970757894 @default.
• W4361291277 cites W1987778106 @default.
• W4361291277 cites W2068428024 @default.
• W4361291277 cites W2069714379 @default.
• W4361291277 cites W2088614543 @default.
• W4361291277 cites W2108068656 @default.
• W4361291277 cites W2110519981 @default.
• W4361291277 cites W2121792680 @default.
• W4361291277 cites W2128985337 @default.
• W4361291277 cites W2257473733 @default.
• W4361291277 cites W2274222782 @default.
• W4361291277 cites W2299952886 @default.
• W4361291277 cites W2401459018 @default.
• W4361291277 cites W2419608838 @default.
• W4361291277 cites W2462023038 @default.
• W4361291277 cites W2507626418 @default.
• W4361291277 cites W2583964565 @default.
• W4361291277 cites W2596754378 @default.
• W4361291277 cites W2613175376 @default.
• W4361291277 cites W2626783532 @default.
• W4361291277 cites W2769664962 @default.
• W4361291277 cites W2781698425 @default.
• W4361291277 cites W2803886706 @default.
• W4361291277 cites W2884435772 @default.
• W4361291277 cites W2889787078 @default.
• W4361291277 cites W2901862653 @default.
• W4361291277 cites W2905456928 @default.
• W4361291277 cites W2910159017 @default.
• W4361291277 cites W2917670625 @default.
• W4361291277 cites W2937189739 @default.
• W4361291277 cites W2954614079 @default.
• W4361291277 cites W2954675852 @default.
• W4361291277 cites W2964183858 @default.
• W4361291277 cites W2981083708 @default.
• W4361291277 cites W2981768636 @default.
• W4361291277 cites W2988014471 @default.
• W4361291277 cites W2996400371 @default.
• W4361291277 cites W3022931916 @default.
• W4361291277 cites W3028618163 @default.
• W4361291277 cites W3034565172 @default.
• W4361291277 cites W3037280692 @default.
• W4361291277 cites W3045021857 @default.
• W4361291277 cites W3087548336 @default.
• W4361291277 cites W3090617035 @default.
• W4361291277 cites W3127031799 @default.
• W4361291277 cites W3155809151 @default.
• W4361291277 cites W3200833022 @default.
• W4361291277 cites W4225122513 @default.
• W4361291277 cites W4282922533 @default.
• W4361291277 cites W4282937730 @default.
• W4361291277 cites W4300864928 @default.
• W4361291277 doi "https://doi.org/10.3389/fchem.2023.1089775" @default.
• W4361291277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37065822" @default.
• W4361291277 hasPublicationYear "2023" @default.
• W4361291277 type Work @default.
• W4361291277 citedByCount "1" @default.
• W4361291277 countsByYear W43612912772023 @default.
• W4361291277 crossrefType "journal-article" @default.
• W4361291277 hasAuthorship W4361291277A5016607883 @default.
• W4361291277 hasAuthorship W4361291277A5022504184 @default.
• W4361291277 hasAuthorship W4361291277A5035210772 @default.
• W4361291277 hasAuthorship W4361291277A5035217108 @default.
• W4361291277 hasAuthorship W4361291277A5036069633 @default.
• W4361291277 hasAuthorship W4361291277A5069331768 @default.
• W4361291277 hasAuthorship W4361291277A5072720203 @default.
• W4361291277 hasBestOaLocation W43612912771 @default.
• W4361291277 hasConcept C142724271 @default.
• W4361291277 hasConcept C185592680 @default.
• W4361291277 hasConcept C203014093 @default.
• W4361291277 hasConcept C2775862500 @default.
• W4361291277 hasConcept C2776151105 @default.
• W4361291277 hasConcept C2776914184 @default.
• W4361291277 hasConcept C2778004101 @default.
• W4361291277 hasConcept C2778260677 @default.
• W4361291277 hasConcept C2779134260 @default.
• W4361291277 hasConcept C48349386 @default.
• W4361291277 hasConcept C539455810 @default.
• W4361291277 hasConcept C55493867 @default.
• W4361291277 hasConcept C71924100 @default.
• W4361291277 hasConcept C98274493 @default.
• W4361291277 hasConceptScore W4361291277C142724271 @default.
• W4361291277 hasConceptScore W4361291277C185592680 @default.
• W4361291277 hasConceptScore W4361291277C203014093 @default.
• W4361291277 hasConceptScore W4361291277C2775862500 @default.
• W4361291277 hasConceptScore W4361291277C2776151105 @default.

• next