FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361296317> ?p ?o ?g. }

• W4361296317 endingPage "108520" @default.
• W4361296317 startingPage "108520" @default.
• W4361296317 abstract "Chagas Disease (CD) affects around eight million people worldwide. It is considered a neglected disease that presents few treatment options with efficacy only in the acute phase. Nanoparticles have many positive qualities for treating parasite infections and may be effectively and widely employed in clinical medicine. This research aimed to evaluate the nanoencapsulated benznidazole treatment in animals experimentally infected with Trypanosoma cruzi. To analyze the treatment efficacy, we evaluated survival during thirty days, parasitemia, genotoxicity, and heart and liver histopathology. Thirty-five female Swiss mice were organized into seven groups characterizing a dose curve: A - Negative control (uninfected animals), B - Positive control (infected animals), C - Benznidazole (BNZ) 100 mg/kg (infected animals), D - 5 mg/kg Benznidazole nanocapsules (NBNZ) (infected animals), E - 10 mg/kg Benznidazole nanocapsules (infected animals), F - 15 mg/kg Benznidazole nanocapsules (infected animals), G - 20 mg/kg Benznidazole nanocapsules (infected animals). The animals were infected with the Y strain of T. cruzi intraperitoneally. The treatment was administered for eight days by oral gavage. It was possible to observe that the treatment with the highest NBNZ dose presented efficacy similar to the standard benznidazole drug. The 20 mg/kg NBNZ dose was able to reduce parasitemia, increase survival, and drastically reduce heart and liver tissue damage compared to the 100 mg/kg BNZ dose. Moreover, it showed a lower DNA damage index than the BNZ treatment. In conclusion, the nanoencapsulation of BNZ promotes an improvement in parasite proliferation control with a five times smaller dose relative to the standard dose of free BNZ, thus demonstrating to be a potential innovative therapy for CD." @default.
• W4361296317 created "2023-03-31" @default.
• W4361296317 creator A5000403255 @default.
• W4361296317 creator A5016883966 @default.
• W4361296317 creator A5018897339 @default.
• W4361296317 creator A5022739213 @default.
• W4361296317 creator A5031409772 @default.
• W4361296317 creator A5043907761 @default.
• W4361296317 creator A5045968540 @default.
• W4361296317 creator A5047508977 @default.
• W4361296317 creator A5052950278 @default.
• W4361296317 creator A5063691024 @default.
• W4361296317 creator A5068192997 @default.
• W4361296317 creator A5069337012 @default.
• W4361296317 creator A5072297080 @default.
• W4361296317 creator A5072681198 @default.
• W4361296317 creator A5072999640 @default.
• W4361296317 creator A5084766875 @default.
• W4361296317 date "2023-06-01" @default.
• W4361296317 modified "2023-09-26" @default.
• W4361296317 title "Trypanosoma cruzi: Does the intake of nanoencapsulated benznidazole control acute infections?" @default.
• W4361296317 cites W1784975412 @default.
• W4361296317 cites W1985093668 @default.
• W4361296317 cites W2026715048 @default.
• W4361296317 cites W2027662826 @default.
• W4361296317 cites W2038214055 @default.
• W4361296317 cites W2049102964 @default.
• W4361296317 cites W2063935469 @default.
• W4361296317 cites W2091343875 @default.
• W4361296317 cites W2152552719 @default.
• W4361296317 cites W2161721368 @default.
• W4361296317 cites W2281175626 @default.
• W4361296317 cites W2332600256 @default.
• W4361296317 cites W2598393292 @default.
• W4361296317 cites W2740065569 @default.
• W4361296317 cites W2761482100 @default.
• W4361296317 cites W2780499990 @default.
• W4361296317 cites W2789444693 @default.
• W4361296317 cites W2900789351 @default.
• W4361296317 cites W2914853610 @default.
• W4361296317 cites W2952606231 @default.
• W4361296317 cites W3186178976 @default.
• W4361296317 cites W4210992500 @default.
• W4361296317 cites W4246443397 @default.
• W4361296317 cites W2952083174 @default.
• W4361296317 doi "https://doi.org/10.1016/j.exppara.2023.108520" @default.
• W4361296317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37001581" @default.
• W4361296317 hasPublicationYear "2023" @default.
• W4361296317 type Work @default.
• W4361296317 citedByCount "0" @default.
• W4361296317 crossrefType "journal-article" @default.
• W4361296317 hasAuthorship W4361296317A5000403255 @default.
• W4361296317 hasAuthorship W4361296317A5016883966 @default.
• W4361296317 hasAuthorship W4361296317A5018897339 @default.
• W4361296317 hasAuthorship W4361296317A5022739213 @default.
• W4361296317 hasAuthorship W4361296317A5031409772 @default.
• W4361296317 hasAuthorship W4361296317A5043907761 @default.
• W4361296317 hasAuthorship W4361296317A5045968540 @default.
• W4361296317 hasAuthorship W4361296317A5047508977 @default.
• W4361296317 hasAuthorship W4361296317A5052950278 @default.
• W4361296317 hasAuthorship W4361296317A5063691024 @default.
• W4361296317 hasAuthorship W4361296317A5068192997 @default.
• W4361296317 hasAuthorship W4361296317A5069337012 @default.
• W4361296317 hasAuthorship W4361296317A5072297080 @default.
• W4361296317 hasAuthorship W4361296317A5072681198 @default.
• W4361296317 hasAuthorship W4361296317A5072999640 @default.
• W4361296317 hasAuthorship W4361296317A5084766875 @default.
• W4361296317 hasConcept C112418997 @default.
• W4361296317 hasConcept C136764020 @default.
• W4361296317 hasConcept C155672457 @default.
• W4361296317 hasConcept C171250308 @default.
• W4361296317 hasConcept C192562407 @default.
• W4361296317 hasConcept C203014093 @default.
• W4361296317 hasConcept C204399865 @default.
• W4361296317 hasConcept C2775867548 @default.
• W4361296317 hasConcept C2776171842 @default.
• W4361296317 hasConcept C2777625466 @default.
• W4361296317 hasConcept C2778048844 @default.
• W4361296317 hasConcept C2778371730 @default.
• W4361296317 hasConcept C41008148 @default.
• W4361296317 hasConcept C71928629 @default.
• W4361296317 hasConcept C86803240 @default.
• W4361296317 hasConcept C98274493 @default.
• W4361296317 hasConceptScore W4361296317C112418997 @default.
• W4361296317 hasConceptScore W4361296317C136764020 @default.
• W4361296317 hasConceptScore W4361296317C155672457 @default.
• W4361296317 hasConceptScore W4361296317C171250308 @default.
• W4361296317 hasConceptScore W4361296317C192562407 @default.
• W4361296317 hasConceptScore W4361296317C203014093 @default.
• W4361296317 hasConceptScore W4361296317C204399865 @default.
• W4361296317 hasConceptScore W4361296317C2775867548 @default.
• W4361296317 hasConceptScore W4361296317C2776171842 @default.
• W4361296317 hasConceptScore W4361296317C2777625466 @default.
• W4361296317 hasConceptScore W4361296317C2778048844 @default.
• W4361296317 hasConceptScore W4361296317C2778371730 @default.
• W4361296317 hasConceptScore W4361296317C41008148 @default.
• W4361296317 hasConceptScore W4361296317C71928629 @default.
• W4361296317 hasConceptScore W4361296317C86803240 @default.

• next