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• W4361297029 startingPage "465" @default.
• W4361297029 abstract "To appraise the literature on the prevalence of the JP2 clone of Aggregatibacter actinomycetemcomitans (A.a.) and on its association with presence and progression of periodontitis in different populations. A systematic search of the literature was conducted in Medline, Embase and Cochrane Library for studies reporting data on detection of the JP2 clone of A.a. A total of 56 papers were included in the review, from an initial search of 685 titles. Studies were carried out in populations with a mean age of 26.34 years (range 6.24-53.85 years). Just over 16% of the overall population assessed (n = 13 751) had the JP2 clone detected. Meta-analyses included 16 studies and 1775 patients, and revealed an association between detection of the JP2 clone and diagnosis of periodontitis (RR = 1.86, 95% 1.43-2.42) from saliva and plaque, with high heterogeneity (I2 = 85%, p < .00001). Meta-analyses included 5 studies and 616 patients, and revealed an association between baseline detection of the JP2 clone and onset of periodontitis over 2 to 5 years (RR = 4.12, 95% 2.42-7.00), with high heterogeneity (I2 = 81%, p < .0003). From the overall risk of bias score, 29 papers were judged as low risk of bias, whilst the remaining papers were judged to have an overall medium or high risk of bias. Detection of the JP2 clone of A.a. in subgingival plaque and saliva samples is associated with increased odds of diagnosis of periodontitis and may be able to predict onset of periodontitis. This systematic review provides clear evidence that in certain populations, the JP2 clone of A.a. is associated with early-onset periodontitis. Furthermore, detection of this bacterium seems to be predictive of disease onset." @default.
• W4361297029 created "2023-03-31" @default.
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• W4361297029 date "2023-03-28" @default.
• W4361297029 modified "2023-10-12" @default.
• W4361297029 title "The association between <i>Aggregatibacter actinomycetemcomitans</i><scp>JP2</scp> clone and periodontitis: A systematic review and meta‐analysis" @default.
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• W4361297029 doi "https://doi.org/10.1111/jre.13102" @default.
• W4361297029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36987541" @default.
• W4361297029 hasPublicationYear "2023" @default.
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