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- W4361298725 endingPage "101838" @default.
- W4361298725 startingPage "101838" @default.
- W4361298725 abstract "Nanomedicines with controlled drug release have received increasing attention as an advanced therapeutic strategy for bone diseases. To traverse biological barriers towards pathological site of bone and endow drug release with spatial, temporal and dose controllability, the design of nanocarriers based on bone microenvironment and their pathological changes during diseases is an attractive idea. Distinguishable biological, physical and chemical features of the bone pathological microenvironment can be exploited to develop targeted and stimuli-responsive nanocarriers thus maximizing the effective enrichment of drugs in the pathological microenvironment. Herein, we present a review of bone targeting strategies based on the characteristics of the bone microenvironment, their pathological changes during bone diseases and corresponding strategies for the construction of stimuli-responsive nanocarriers. The available stimuli in the context of bone disease, design principles of stimuli-responsive delivery systems and recent advances in their application for bone therapy were highlighted. Thereby, the emerging new concept, that is, the bone microenvironment-responsive drug delivery system, was systematically illustrated. Furthermore, the challenges and future prospects of such smart drug delivery systems for bone therapy applications are discussed." @default.
- W4361298725 created "2023-03-31" @default.
- W4361298725 creator A5019324414 @default.
- W4361298725 creator A5042968243 @default.
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- W4361298725 creator A5068120409 @default.
- W4361298725 creator A5075798027 @default.
- W4361298725 creator A5083304846 @default.
- W4361298725 date "2023-06-01" @default.
- W4361298725 modified "2023-10-17" @default.
- W4361298725 title "Microenvironment-responsive nanocarriers for targeted bone disease therapy" @default.
- W4361298725 cites W1520693177 @default.
- W4361298725 cites W1570371805 @default.
- W4361298725 cites W1812298537 @default.
- W4361298725 cites W1966090623 @default.
- W4361298725 cites W1976599392 @default.
- W4361298725 cites W1992104196 @default.
- W4361298725 cites W2002140154 @default.
- W4361298725 cites W2002387722 @default.
- W4361298725 cites W2006950202 @default.
- W4361298725 cites W2013462509 @default.
- W4361298725 cites W2035847235 @default.
- W4361298725 cites W2038773696 @default.
- W4361298725 cites W2039337813 @default.
- W4361298725 cites W2044364321 @default.
- W4361298725 cites W2047103966 @default.
- W4361298725 cites W2053958243 @default.
- W4361298725 cites W2057907407 @default.
- W4361298725 cites W2062845561 @default.
- W4361298725 cites W2067864034 @default.
- W4361298725 cites W2070166910 @default.
- W4361298725 cites W2077382874 @default.
- W4361298725 cites W2082273415 @default.
- W4361298725 cites W2082527312 @default.
- W4361298725 cites W2085294880 @default.
- W4361298725 cites W2087278753 @default.
- W4361298725 cites W2089946256 @default.
- W4361298725 cites W2091982741 @default.
- W4361298725 cites W2093252878 @default.
- W4361298725 cites W2094305477 @default.
- W4361298725 cites W2112899718 @default.
- W4361298725 cites W2123251003 @default.
- W4361298725 cites W2126598569 @default.
- W4361298725 cites W2130166533 @default.
- W4361298725 cites W2137208120 @default.
- W4361298725 cites W2142098425 @default.
- W4361298725 cites W2150433909 @default.
- W4361298725 cites W2150904792 @default.
- W4361298725 cites W2153737037 @default.
- W4361298725 cites W2164993228 @default.
- W4361298725 cites W2169251377 @default.
- W4361298725 cites W2169989707 @default.
- W4361298725 cites W2178973057 @default.
- W4361298725 cites W2273046299 @default.
- W4361298725 cites W2284013896 @default.
- W4361298725 cites W2294780803 @default.
- W4361298725 cites W2295088026 @default.
- W4361298725 cites W2335387660 @default.
- W4361298725 cites W2395165578 @default.
- W4361298725 cites W2404917567 @default.
- W4361298725 cites W2414931639 @default.
- W4361298725 cites W24657202 @default.
- W4361298725 cites W2511358268 @default.
- W4361298725 cites W2513830982 @default.
- W4361298725 cites W2527186678 @default.
- W4361298725 cites W2562497953 @default.
- W4361298725 cites W2567088630 @default.
- W4361298725 cites W2575553491 @default.
- W4361298725 cites W2588922129 @default.
- W4361298725 cites W2593333911 @default.
- W4361298725 cites W2610501391 @default.
- W4361298725 cites W2614666068 @default.
- W4361298725 cites W2622000437 @default.
- W4361298725 cites W2701735408 @default.
- W4361298725 cites W2728148193 @default.
- W4361298725 cites W2729890352 @default.
- W4361298725 cites W2767545886 @default.
- W4361298725 cites W2775143243 @default.
- W4361298725 cites W2788887866 @default.
- W4361298725 cites W2793880258 @default.
- W4361298725 cites W2796008581 @default.
- W4361298725 cites W2799739706 @default.
- W4361298725 cites W2800973211 @default.
- W4361298725 cites W2802485650 @default.
- W4361298725 cites W2804996202 @default.
- W4361298725 cites W2806973106 @default.
- W4361298725 cites W2807564415 @default.
- W4361298725 cites W2810219991 @default.
- W4361298725 cites W2889101189 @default.
- W4361298725 cites W2896491161 @default.
- W4361298725 cites W2896582829 @default.
- W4361298725 cites W2899609926 @default.
- W4361298725 cites W2911585454 @default.
- W4361298725 cites W2913632448 @default.
- W4361298725 cites W2921117033 @default.
- W4361298725 cites W2935852942 @default.
- W4361298725 cites W2952308011 @default.
- W4361298725 cites W2953790914 @default.