FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361301466> ?p ?o ?g. }

• W4361301466 abstract "Abstract Inadequate immune response to vaccination is a long-standing problem faced by immunosuppressed kidney transplant recipients (KTRs), requiring novel strategies to improve vaccine efficacy. In this study, the potential of mechanistic target of rapamycin inhibitors (mTORi) to improve T cell responses to COVID-19 vaccination was investigated. Following primary vaccination with adenoviral (ChAdOx1) or mRNA (BNT162b2) COVID-19 vaccines, KTRs receiving rapamycin demonstrated T cell responses greater than those of healthy individuals, characterized by increased frequencies of vaccine-specific central memory, effector memory and T EMRA T cells, in both the CD4 + and CD8 + compartments. Relative to standard-of-care triple therapy, mTORi-based therapy was associated with a 12-fold greater functional T cell response to primary vaccination of KTRs. The use of rapamycin to augment T cell responses to COVID-19 booster (third dose) vaccination was next investigated in a randomized, controlled trial. Immunosuppression modification with rapamycin was feasible and well-tolerated, but did not improve vaccine-specific T cell responses in this cohort. To understand the parameters for effective use of rapamycin as a vaccine adjuvant, mice were treated with rapamycin before primary or booster vaccination with ancestral and/or Omicron COVID-19 vaccines. Supporting the findings from KTRs, significant enhancement of functional and stem-like memory T cell responses was observed when rapamycin was administered from the time of primary, rather than booster, vaccination. Collectively, a positive effect of mTOR inhibitors on vaccine-induced T cell immunity against COVID-19 in humans was demonstrated. One Sentence Summary Rapamycin use at the time of primary COVID-19 vaccination augments the formation of functional, vaccine-specific T cell memory in immunosuppressed kidney transplant recipients." @default.
• W4361301466 created "2023-03-31" @default.
• W4361301466 creator A5003300889 @default.
• W4361301466 creator A5003765303 @default.
• W4361301466 creator A5007038261 @default.
• W4361301466 creator A5010966529 @default.
• W4361301466 creator A5017768675 @default.
• W4361301466 creator A5023193578 @default.
• W4361301466 creator A5024082558 @default.
• W4361301466 creator A5024478613 @default.
• W4361301466 creator A5024506446 @default.
• W4361301466 creator A5034792012 @default.
• W4361301466 creator A5038337573 @default.
• W4361301466 creator A5038847793 @default.
• W4361301466 creator A5039966569 @default.
• W4361301466 creator A5042727329 @default.
• W4361301466 creator A5049395326 @default.
• W4361301466 creator A5050901953 @default.
• W4361301466 creator A5051912218 @default.
• W4361301466 creator A5054004188 @default.
• W4361301466 creator A5054938965 @default.
• W4361301466 creator A5065252306 @default.
• W4361301466 creator A5065785507 @default.
• W4361301466 creator A5071431150 @default.
• W4361301466 creator A5072253049 @default.
• W4361301466 creator A5073772726 @default.
• W4361301466 creator A5076698112 @default.
• W4361301466 creator A5079594258 @default.
• W4361301466 creator A5080039905 @default.
• W4361301466 creator A5083050528 @default.
• W4361301466 creator A5084767969 @default.
• W4361301466 creator A5090036682 @default.
• W4361301466 creator A5090658610 @default.
• W4361301466 creator A5090954355 @default.
• W4361301466 date "2023-03-29" @default.
• W4361301466 modified "2023-09-27" @default.
• W4361301466 title "mTOR inhibition improves the formation of functional T cell memory following COVID-19 vaccination of kidney transplant recipients" @default.
• W4361301466 cites W1527904207 @default.
• W4361301466 cites W1551513387 @default.
• W4361301466 cites W1820532154 @default.
• W4361301466 cites W1903749320 @default.
• W4361301466 cites W1981217826 @default.
• W4361301466 cites W1989210948 @default.
• W4361301466 cites W1990174512 @default.
• W4361301466 cites W1994938942 @default.
• W4361301466 cites W1995188922 @default.
• W4361301466 cites W1998969417 @default.
• W4361301466 cites W2001775594 @default.
• W4361301466 cites W2034721463 @default.
• W4361301466 cites W2059689009 @default.
• W4361301466 cites W2064876347 @default.
• W4361301466 cites W2066738380 @default.
• W4361301466 cites W2076787697 @default.
• W4361301466 cites W2084253027 @default.
• W4361301466 cites W2100714842 @default.
• W4361301466 cites W2103051735 @default.
• W4361301466 cites W2108565052 @default.
• W4361301466 cites W2126500343 @default.
• W4361301466 cites W2130746744 @default.
• W4361301466 cites W2133997960 @default.
• W4361301466 cites W2135360970 @default.
• W4361301466 cites W2140965118 @default.
• W4361301466 cites W2149010238 @default.
• W4361301466 cites W2157034871 @default.
• W4361301466 cites W2259021796 @default.
• W4361301466 cites W2321920454 @default.
• W4361301466 cites W2569985415 @default.
• W4361301466 cites W2570323108 @default.
• W4361301466 cites W2588256621 @default.
• W4361301466 cites W2765584638 @default.
• W4361301466 cites W2789400684 @default.
• W4361301466 cites W2799859234 @default.
• W4361301466 cites W2800597319 @default.
• W4361301466 cites W2804798591 @default.
• W4361301466 cites W2844364183 @default.
• W4361301466 cites W2904513399 @default.
• W4361301466 cites W2996498622 @default.
• W4361301466 cites W3037718428 @default.
• W4361301466 cites W3044914269 @default.
• W4361301466 cites W3116375528 @default.
• W4361301466 cites W3162400064 @default.
• W4361301466 cites W3163785571 @default.
• W4361301466 cites W3176897911 @default.
• W4361301466 cites W3182196820 @default.
• W4361301466 cites W3183904285 @default.
• W4361301466 cites W3184440107 @default.
• W4361301466 cites W3190427561 @default.
• W4361301466 cites W3196516725 @default.
• W4361301466 cites W3199923482 @default.
• W4361301466 cites W3201836196 @default.
• W4361301466 cites W3202923037 @default.
• W4361301466 cites W3216507411 @default.
• W4361301466 cites W4205456303 @default.
• W4361301466 cites W4205460108 @default.
• W4361301466 cites W4205501154 @default.
• W4361301466 cites W4205695870 @default.
• W4361301466 cites W4207083212 @default.
• W4361301466 cites W4210249750 @default.
• W4361301466 cites W4211201559 @default.
• W4361301466 cites W4213115002 @default.

• next