Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361301934> ?p ?o ?g. }
- W4361301934 endingPage "829" @default.
- W4361301934 startingPage "829" @default.
- W4361301934 abstract "A common feature of different types of diabetes is the high blood glucose levels, which are known to induce a series of metabolic alterations, leading to damaging events in different tissues. Among these alterations, both increased polyol pathway flux and oxidative stress are considered to play relevant roles in the response of different cells. In this work, the effect on a human lens epithelial cell line of stress conditions, consisting of exposure to either high glucose levels or to the lipid peroxidation product 4-hydroxy-2-nonenal, is reported. The occurrence of osmotic imbalance, alterations of glutathione levels, and expression of inflammatory markers was monitored. A common feature of the two stress conditions was the expression of COX-2, which, only in the case of hyperglycemic stress, occurred through NF-κB activation. In our cell model, aldose reductase activity, which is confirmed as the only activity responsible for the osmotic imbalance occurring in hyperglycemic conditions, seemed to have no role in controlling the onset of the inflammatory phenomena. However, it played a relevant role in cellular detoxification against lipid peroxidation products. These results, in confirming the multifactorial nature of the inflammatory phenomena, highlight the dual role of aldose reductase as having both damaging but also protecting activity, depending on stress conditions." @default.
- W4361301934 created "2023-03-31" @default.
- W4361301934 creator A5002616891 @default.
- W4361301934 creator A5006433955 @default.
- W4361301934 creator A5008246765 @default.
- W4361301934 creator A5011184988 @default.
- W4361301934 creator A5031164933 @default.
- W4361301934 creator A5033342633 @default.
- W4361301934 creator A5061815936 @default.
- W4361301934 creator A5075459608 @default.
- W4361301934 date "2023-03-28" @default.
- W4361301934 modified "2023-09-26" @default.
- W4361301934 title "Response of a Human Lens Epithelial Cell Line to Hyperglycemic and Oxidative Stress: The Role of Aldose Reductase" @default.
- W4361301934 cites W1535946984 @default.
- W4361301934 cites W1638882029 @default.
- W4361301934 cites W1694093395 @default.
- W4361301934 cites W1729003770 @default.
- W4361301934 cites W1968209863 @default.
- W4361301934 cites W1968963416 @default.
- W4361301934 cites W1969096292 @default.
- W4361301934 cites W1971872466 @default.
- W4361301934 cites W1974318049 @default.
- W4361301934 cites W1975560094 @default.
- W4361301934 cites W1975800000 @default.
- W4361301934 cites W1979308463 @default.
- W4361301934 cites W1984121660 @default.
- W4361301934 cites W1986604347 @default.
- W4361301934 cites W1989546594 @default.
- W4361301934 cites W1991740116 @default.
- W4361301934 cites W1998812648 @default.
- W4361301934 cites W2000054651 @default.
- W4361301934 cites W2002709542 @default.
- W4361301934 cites W2005379932 @default.
- W4361301934 cites W2012476374 @default.
- W4361301934 cites W2016230296 @default.
- W4361301934 cites W2018828431 @default.
- W4361301934 cites W2020117421 @default.
- W4361301934 cites W2023346299 @default.
- W4361301934 cites W2030082547 @default.
- W4361301934 cites W2032378135 @default.
- W4361301934 cites W2041906033 @default.
- W4361301934 cites W2043828707 @default.
- W4361301934 cites W2057066861 @default.
- W4361301934 cites W2057522312 @default.
- W4361301934 cites W2058806296 @default.
- W4361301934 cites W2064473116 @default.
- W4361301934 cites W2065223208 @default.
- W4361301934 cites W2083390495 @default.
- W4361301934 cites W2087644601 @default.
- W4361301934 cites W2094001761 @default.
- W4361301934 cites W2111179436 @default.
- W4361301934 cites W2114048957 @default.
- W4361301934 cites W2114918609 @default.
- W4361301934 cites W2127908806 @default.
- W4361301934 cites W2128635872 @default.
- W4361301934 cites W2134240491 @default.
- W4361301934 cites W2137124441 @default.
- W4361301934 cites W2138443291 @default.
- W4361301934 cites W2148489323 @default.
- W4361301934 cites W2150790322 @default.
- W4361301934 cites W2272023237 @default.
- W4361301934 cites W2312266417 @default.
- W4361301934 cites W2322794129 @default.
- W4361301934 cites W2468150319 @default.
- W4361301934 cites W2509547325 @default.
- W4361301934 cites W2576886517 @default.
- W4361301934 cites W2592787819 @default.
- W4361301934 cites W2750773993 @default.
- W4361301934 cites W2767404919 @default.
- W4361301934 cites W2767589056 @default.
- W4361301934 cites W2791517164 @default.
- W4361301934 cites W2886442927 @default.
- W4361301934 cites W2898475790 @default.
- W4361301934 cites W2971776822 @default.
- W4361301934 cites W2981357167 @default.
- W4361301934 cites W2988380178 @default.
- W4361301934 cites W3014264523 @default.
- W4361301934 cites W3022762329 @default.
- W4361301934 cites W3039473905 @default.
- W4361301934 cites W3185184399 @default.
- W4361301934 cites W4220716011 @default.
- W4361301934 cites W4224218680 @default.
- W4361301934 cites W4293247451 @default.
- W4361301934 cites W4306316468 @default.
- W4361301934 doi "https://doi.org/10.3390/antiox12040829" @default.
- W4361301934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37107204" @default.
- W4361301934 hasPublicationYear "2023" @default.
- W4361301934 type Work @default.
- W4361301934 citedByCount "0" @default.
- W4361301934 crossrefType "journal-article" @default.
- W4361301934 hasAuthorship W4361301934A5002616891 @default.
- W4361301934 hasAuthorship W4361301934A5006433955 @default.
- W4361301934 hasAuthorship W4361301934A5008246765 @default.
- W4361301934 hasAuthorship W4361301934A5011184988 @default.
- W4361301934 hasAuthorship W4361301934A5031164933 @default.
- W4361301934 hasAuthorship W4361301934A5033342633 @default.
- W4361301934 hasAuthorship W4361301934A5061815936 @default.
- W4361301934 hasAuthorship W4361301934A5075459608 @default.