Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361301936> ?p ?o ?g. }
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- W4361301936 startingPage "217" @default.
- W4361301936 abstract "Ca2+/voltage-gated, large conductance K+ channels (BKCa) are formed by homotetrameric association of α (slo1) subunits. Their activity, however, is suited to tissue-specific physiology largely due to their association with regulatory subunits (β and γ types), chaperone proteins, localized signaling, and the channel's lipid microenvironment. PIP2 and cholesterol can modulate BKCa activity independently of downstream signaling, yet activating Ca2+i levels and regulatory subunits control ligand action. At physiological Ca2+i and voltages, cholesterol and PIP2 reduce and increase slo1 channel activity, respectively. Moreover, slo1 proteins provide sites that seem to recognize cholesterol and PIP2: seven CRAC motifs in the slo1 cytosolic tail and a string of positively charged residues (Arg329, Lys330, Lys331) immediately after S6, respectively. A model that could explain the modulation of BKCa activity by cholesterol and/or PIP2 is hypothesized. The roles of additional sites, whether in slo1 or BKCa regulatory subunits, for PIP2 and/or cholesterol to modulate BKCa function are also discussed." @default.
- W4361301936 created "2023-03-31" @default.
- W4361301936 creator A5020112417 @default.
- W4361301936 creator A5028569011 @default.
- W4361301936 creator A5040634776 @default.
- W4361301936 creator A5068679074 @default.
- W4361301936 date "2023-01-01" @default.
- W4361301936 modified "2023-09-26" @default.
- W4361301936 title "Cholesterol and PIP2 Modulation of BKCa Channels." @default.
- W4361301936 cites W1525636180 @default.
- W4361301936 cites W1548284001 @default.
- W4361301936 cites W1555686373 @default.
- W4361301936 cites W183810266 @default.
- W4361301936 cites W1964634922 @default.
- W4361301936 cites W1966510836 @default.
- W4361301936 cites W1973330766 @default.
- W4361301936 cites W1973996146 @default.
- W4361301936 cites W1975575557 @default.
- W4361301936 cites W1981149142 @default.
- W4361301936 cites W1987475266 @default.
- W4361301936 cites W1987604530 @default.
- W4361301936 cites W1988661228 @default.
- W4361301936 cites W1989915158 @default.
- W4361301936 cites W1991675939 @default.
- W4361301936 cites W1992215989 @default.
- W4361301936 cites W1992862772 @default.
- W4361301936 cites W1993875060 @default.
- W4361301936 cites W1994215475 @default.
- W4361301936 cites W1994758544 @default.
- W4361301936 cites W2007372862 @default.
- W4361301936 cites W2010779574 @default.
- W4361301936 cites W2011909518 @default.
- W4361301936 cites W2013853780 @default.
- W4361301936 cites W2014959401 @default.
- W4361301936 cites W2017557863 @default.
- W4361301936 cites W2018981746 @default.
- W4361301936 cites W2020185913 @default.
- W4361301936 cites W2023125175 @default.
- W4361301936 cites W2026674570 @default.
- W4361301936 cites W2031038371 @default.
- W4361301936 cites W2033595304 @default.
- W4361301936 cites W2034146282 @default.
- W4361301936 cites W2037714333 @default.
- W4361301936 cites W2040092696 @default.
- W4361301936 cites W2042324409 @default.
- W4361301936 cites W2052454481 @default.
- W4361301936 cites W2054799935 @default.
- W4361301936 cites W2056189730 @default.
- W4361301936 cites W2058366779 @default.
- W4361301936 cites W2059874589 @default.
- W4361301936 cites W2065174968 @default.
- W4361301936 cites W2069519194 @default.
- W4361301936 cites W2071251525 @default.
- W4361301936 cites W2072994787 @default.
- W4361301936 cites W2081964427 @default.
- W4361301936 cites W2084903350 @default.
- W4361301936 cites W2087530259 @default.
- W4361301936 cites W2094069152 @default.
- W4361301936 cites W2097411147 @default.
- W4361301936 cites W2098563084 @default.
- W4361301936 cites W2100081225 @default.
- W4361301936 cites W2101009136 @default.
- W4361301936 cites W2109042906 @default.
- W4361301936 cites W2113368771 @default.
- W4361301936 cites W2113755495 @default.
- W4361301936 cites W2114660894 @default.
- W4361301936 cites W2115676911 @default.
- W4361301936 cites W2119806797 @default.
- W4361301936 cites W2120077272 @default.
- W4361301936 cites W2129223465 @default.
- W4361301936 cites W2130469719 @default.
- W4361301936 cites W2131883978 @default.
- W4361301936 cites W2135923426 @default.
- W4361301936 cites W2137632894 @default.
- W4361301936 cites W2138936877 @default.
- W4361301936 cites W2141832664 @default.
- W4361301936 cites W2144124959 @default.
- W4361301936 cites W2145339110 @default.
- W4361301936 cites W2149390328 @default.
- W4361301936 cites W2151694767 @default.
- W4361301936 cites W2158424460 @default.
- W4361301936 cites W2161618623 @default.
- W4361301936 cites W2161947280 @default.
- W4361301936 cites W2162228329 @default.
- W4361301936 cites W2164277707 @default.
- W4361301936 cites W2166084555 @default.
- W4361301936 cites W2246457688 @default.
- W4361301936 cites W2405748645 @default.
- W4361301936 cites W2408517559 @default.
- W4361301936 cites W2415014109 @default.
- W4361301936 cites W2507433039 @default.
- W4361301936 cites W2547422794 @default.
- W4361301936 cites W2564149183 @default.
- W4361301936 cites W2564652835 @default.
- W4361301936 cites W2588480034 @default.
- W4361301936 cites W2606367967 @default.
- W4361301936 cites W2802473818 @default.
- W4361301936 cites W2910916399 @default.