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• W4361302022 endingPage "133753" @default.
• W4361302022 startingPage "133753" @default.
• W4361302022 abstract "As a next-generation biosensing technology, the application of Argonaute for analytical science research has attracted considerable attention. A Thermus thermophilus Argonaute (TtAgo)-based sensor is presented for detecting T4 polynucleotide kinase (PNK) activity considering that TtAgo’s multiple-turnover catalytic activity can be activated by binding to a 5′-phosphate termini of single-stranded DNA (ssDNA) for the cleavage of complementary strand. PNK catalyzes the phosphorylation of 5′-hydroxyl termini of ssDNA, and the phosphorylation product termed guide can activate the TtAgo-mediated complementary ssDNA reporter cleavage to release fluorescence signal. For the PNK activity monitoring, the developed method shows good analytic performance with a linear range of 0.0010–2 U mL−1 and a detection limit of 0.0010 U mL−1 without the use of a preamplification reaction. This method is successfully applied for the analysis of HeLa cells at a single-cell level. The developed method shows several advantages, including high sensitivity, low cost, facile operation, and has remarkable potential application for early disease diagnosis, drug screening, and clinical treatment." @default.
• W4361302022 created "2023-03-31" @default.
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• W4361302022 date "2023-07-01" @default.
• W4361302022 modified "2023-09-30" @default.
• W4361302022 title "TtAgo sensor for the sensitive and rapid detection of T4 polynucleotide kinase activity" @default.
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• W4361302022 doi "https://doi.org/10.1016/j.snb.2023.133753" @default.
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