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- W4361745362 abstract "No AccessJournal of UrologyPEDIATRIC UROLOGY1 Nov 2001LONG-TERM FOLLOWUP OF CHILDREN TREATED WITH DEXTRANOMER/HYALURONIC ACID COPOLYMER FOR VESICOURETERAL REFLUX GÖRAN LÄCKGREN, NILS WÅHLIN, ERIK SKÖLDENBERG, and ARNE STENBERG GÖRAN LÄCKGRENGÖRAN LÄCKGREN More articles by this author , NILS WÅHLINNILS WÅHLIN More articles by this author , ERIK SKÖLDENBERGERIK SKÖLDENBERG More articles by this author , and ARNE STENBERGARNE STENBERG More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65713-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Dextranomer/hyaluronic acid copolymer is a novel substance that has favorable properties for endoscopic treatment of vesicoureteral reflux. We assess the long-term efficacy and safety of this treatment of children. Materials and Methods: Children 1 to 15 years old with grade III or greater vesicoureteral reflux were eligible for enrollment in our study. All patients received endoscopic treatment with dextranomer/hyaluronic acid copolymer and were scheduled to have a voiding cystourethrogram 3 and 12 months after implantation. Children with reflux grade III or greater after treatment received up to 2 more implantations, and those with persistent reflux were referred for open surgery. In some cases long-term clinical followup was accompanied by a late voiding cystourethrogram. Results: A total of 228 patients received endoscopic treatment. The efficacy population was comprised of 221 children, including 67 who received 2 and 8 who received 3 implantations. Endoscopic treatment was performed without complications in all cases. Patients were followed clinically for 2 to 7.5 years (mean 5). On the last voiding cystourethrogram 68% of patients had a positive response (grade I or less) and 81% had no dilating reflux. The corresponding results for treated ureters were 75% and 85%, respectively. Only 27 (12%) patients were referred for open surgery. A late voiding cystourethrogram was performed in 49 patients 2 to 5 years after treatment. Of the ureters free of reflux (grade 0) 3 to 12 months after treatment 96% remained free of dilating reflux. Adverse events occurred in association with implantation in only 2% of patients, although urinary tract infection subsequently developed in 8%. Conclusions: Endoscopic treatment with dextranomer/hyaluronic acid copolymer was effective and well tolerated in children with vesicoureteral reflux. Long-term followup indicated that there was no deterioration in patients responding positively to treatment. References 1 : Vesico-ureteric reflux: occurrence and long-term risks. Acta Paediatr1999; 431: 22. 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Google Scholar From the Section of Urology, University Children’s Hospital, Uppsala, Sweden© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byFiorenza V, Hukkinen M, Alova I, Clermidi P, Broch A, Botto N, Blanc T and Lottmann H (2022) Dextranomer Endoscopic Injections for the Treatment of Urinary Incontinence in Bladder Exstrophy-epispadias ComplexJournal of Urology, Ramsay S, Blais A, Morin F, Moore K, Cloutier J and Bolduc S (2016) Polyacrylamide Hydrogel as a Bulking Agent for the Endoscopic Treatment of Vesicoureteral Reflux: Long-Term Results and SafetyJournal of Urology, VOL. 197, NO. 3 Part 2, (963-967), Online publication date: 1-Mar-2017.Akiki A, Boissier R, Delaporte V, Maurin C, Gaillet S, Karsenty G, Coulange C and Lechevallier E (2018) Endoscopic Treatment of Symptomatic Vesicoureteral Reflux after Renal TransplantationJournal of Urology, VOL. 193, NO. 1, (225-229), Online publication date: 1-Jan-2015.Cloutier J, Blais A, Moore K and Bolduc S (2018) Prospective Study Using a New Bulking Agent for the Treatment of Vesicoureteral Reflux: Polyacrylamide HydrogelJournal of Urology, VOL. 190, NO. 3, (1034-1037), Online publication date: 1-Sep-2013.Kajbafzadeh A and Tourchi A (2018) Usefulness of Concomitant Autologous Blood and Dextranomer/Hyaluronic Acid Copolymer Injection to Correct Vesicoureteral RefluxJournal of Urology, VOL. 188, NO. 3, (948-952), Online publication date: 1-Sep-2012.Sparks S, DeCambre M, Christman M, Kaplan G and Holmes N (2018) Salvage Ureteral Reimplantation After Failure of Dextranomer/Hyaluronic Acid InjectionJournal of Urology, VOL. 186, NO. 1, (257-260), Online publication date: 1-Jul-2011.Cendron M (2011) Editorial CommentJournal of Urology, VOL. 185, NO. 6S, (2540-2540), Online publication date: 1-Jun-2011.Holmdahl G, Brandström P, Läckgren G, Sillén U, Stokland E, Jodal U and Hansson S (2018) The Swedish Reflux Trial in Children: II. 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(2018) EDITORIAL COMMENTJournal of Urology, VOL. 167, NO. 3, (1445-1446), Online publication date: 1-Mar-2002. Volume 166Issue 5November 2001Page: 1887-1892 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.Keywordsendoscopyureterhyaluronic acidchildvesico-ureteral refluxMetricsAuthor Information GÖRAN LÄCKGREN More articles by this author NILS WÅHLIN More articles by this author ERIK SKÖLDENBERG More articles by this author ARNE STENBERG More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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