FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361762284> ?p ?o ?g. }

• W4361762284 endingPage "55" @default.
• W4361762284 startingPage "13" @default.
• W4361762284 abstract "Background: Depression is a typical psychosomatic disease. Shuganheweitang (SGHWT) is a clinical formula that effectively treats depression. However, the potential mechanism used by SGHWT to ameliorate depression-like behaviors is still unclear. This study investigated the effects of SGHWT on metabolic change in the liver and hypothalamus with signaling pathways involved in chronic unpredictable mild stress (CUMS)-induced depression in rats to explore the mechanism of the anti-depressive effect. Methods: A total of 52 rats were used to create a model of depression by CUMS combined with solitary rearing for 6 weeks. Open field test (OFT), sucrose preference test (SPT), forced swim test (FST), and body weight (BW) were performed to analyze the pharmacodynamic effects of SGHWT. H&E staining, Nissl staining, immunofluorescence, immunohistochemistry, and western blot were used to evaluate the mechanism of action. Untargeted metabolomics techniques by ultra-performance liquid chromatography-quantitative time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS) were used to analyze all the metabolic differences in the liver and hypothalamus. Results: SGHWT improved CUMS-induced depression-like behaviors in vivo. SGHWT reduced hepatic c-Fos protein expression and increased hypothalamic c-Fos protein expression. Moreover, p-PI3K, p-AKT473, p-AKT308, and p-mTOR protein expressions were significantly downregulated in the liver and hypothalamus of CUMS rats. Notably, these alterations were reversed by the SGHWT administration. Furthermore, the metabolomic analysis identified 15 and 5 key differential SPT-associated metabolites in the liver and hypothalamus, respectively. Conclusion: This study suggests that SGHWT ameliorates chronic unpredictable mild stress-induced depression-like behaviors, by the involvement of amino acids, glycerophospholipids, energy metabolism, and the PI3K/AKT/mTOR pathway. Highlights: 1) Shuganheweitang was derived from the TCM herbal formula Sinisan. 2) SGHWT treatment reverses depression-like behaviors in CUMS-induced rats. 3) The mechanism of SGHWT on depression by the liver and hypothalamus metabolomics. 4) SGHWT regulates amino acids, glycerophospholipids, and energy metabolism. 5) SGHWT exerts antidepressant effects through the PI3K/AKT/mTOR pathway." @default.
• W4361762284 created "2023-04-04" @default.
• W4361762284 creator A5013503262 @default.
• W4361762284 creator A5020746135 @default.
• W4361762284 creator A5029283570 @default.
• W4361762284 creator A5044266815 @default.
• W4361762284 creator A5052102629 @default.
• W4361762284 creator A5052423314 @default.
• W4361762284 creator A5064711465 @default.
• W4361762284 creator A5072105039 @default.
• W4361762284 creator A5075301454 @default.
• W4361762284 creator A5076794373 @default.
• W4361762284 creator A5080566282 @default.
• W4361762284 creator A5082192610 @default.
• W4361762284 date "2023-01-01" @default.
• W4361762284 modified "2023-09-29" @default.
• W4361762284 title "Shuganheweitang Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-Like Behaviors in Rats through the PI3K/AKT/mTOR Pathway: Involvement of Amino Acids, Glycerophospholipids, and Energy Metabolism" @default.
• W4361762284 cites W1794183545 @default.
• W4361762284 cites W1883693716 @default.
• W4361762284 cites W1963797661 @default.
• W4361762284 cites W1965766554 @default.
• W4361762284 cites W1971703620 @default.
• W4361762284 cites W1976327561 @default.
• W4361762284 cites W1987226347 @default.
• W4361762284 cites W1998770222 @default.
• W4361762284 cites W2006842959 @default.
• W4361762284 cites W2014201145 @default.
• W4361762284 cites W2019087671 @default.
• W4361762284 cites W2061690520 @default.
• W4361762284 cites W2065214489 @default.
• W4361762284 cites W2067927862 @default.
• W4361762284 cites W2074648434 @default.
• W4361762284 cites W2086692662 @default.
• W4361762284 cites W2098539376 @default.
• W4361762284 cites W2118659222 @default.
• W4361762284 cites W2138092997 @default.
• W4361762284 cites W2142935817 @default.
• W4361762284 cites W2324264094 @default.
• W4361762284 cites W2343114247 @default.
• W4361762284 cites W2474498474 @default.
• W4361762284 cites W2551118580 @default.
• W4361762284 cites W2566565838 @default.
• W4361762284 cites W2672668855 @default.
• W4361762284 cites W2751703244 @default.
• W4361762284 cites W2787880257 @default.
• W4361762284 cites W2790486637 @default.
• W4361762284 cites W2799952127 @default.
• W4361762284 cites W2802741176 @default.
• W4361762284 cites W2901222235 @default.
• W4361762284 cites W2904597631 @default.
• W4361762284 cites W2909844589 @default.
• W4361762284 cites W2912651186 @default.
• W4361762284 cites W2960036557 @default.
• W4361762284 cites W2960960591 @default.
• W4361762284 cites W2964841678 @default.
• W4361762284 cites W2969637735 @default.
• W4361762284 cites W2970852449 @default.
• W4361762284 cites W2980797713 @default.
• W4361762284 cites W2982172561 @default.
• W4361762284 cites W2992985193 @default.
• W4361762284 cites W3006289903 @default.
• W4361762284 cites W3010456933 @default.
• W4361762284 cites W3011959153 @default.
• W4361762284 cites W3012139133 @default.
• W4361762284 cites W3013784089 @default.
• W4361762284 cites W3014240006 @default.
• W4361762284 cites W3024183716 @default.
• W4361762284 cites W3033644778 @default.
• W4361762284 cites W3043165528 @default.
• W4361762284 cites W3047938954 @default.
• W4361762284 cites W3053004165 @default.
• W4361762284 cites W3087546004 @default.
• W4361762284 cites W3127980075 @default.
• W4361762284 cites W3132000637 @default.
• W4361762284 cites W3158389302 @default.
• W4361762284 cites W3160570155 @default.
• W4361762284 cites W3164510424 @default.
• W4361762284 cites W3193280260 @default.
• W4361762284 cites W3198761369 @default.
• W4361762284 cites W3202181531 @default.
• W4361762284 cites W4200438042 @default.
• W4361762284 cites W4211263234 @default.
• W4361762284 cites W4285741554 @default.
• W4361762284 doi "https://doi.org/10.4236/cm.2023.141002" @default.
• W4361762284 hasPublicationYear "2023" @default.
• W4361762284 type Work @default.
• W4361762284 citedByCount "0" @default.
• W4361762284 crossrefType "journal-article" @default.
• W4361762284 hasAuthorship W4361762284A5013503262 @default.
• W4361762284 hasAuthorship W4361762284A5020746135 @default.
• W4361762284 hasAuthorship W4361762284A5029283570 @default.
• W4361762284 hasAuthorship W4361762284A5044266815 @default.
• W4361762284 hasAuthorship W4361762284A5052102629 @default.
• W4361762284 hasAuthorship W4361762284A5052423314 @default.
• W4361762284 hasAuthorship W4361762284A5064711465 @default.
• W4361762284 hasAuthorship W4361762284A5072105039 @default.
• W4361762284 hasAuthorship W4361762284A5075301454 @default.
• W4361762284 hasAuthorship W4361762284A5076794373 @default.

• next