Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361765568> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4361765568 endingPage "2845" @default.
- W4361765568 startingPage "2839" @default.
- W4361765568 abstract "Purpose: To explore the impact of VEGF pathway on the M1 polarization and function of macrophages. Methods: VEGFR-knockdown macrophages were established by transfected with a shRNA. M1 macrophages were stimulated by LPS and IFN- γ , which was identified using the flow cytometry. Subsequently, M1 macrophages were treated with VEGF A, VEGF B, and PIGF, respectively. The expression level of iNOS, TNF- α , and IL-6 was detected utilizing RT-PCR. CD86 and iNOS level were checked by Western blot. The migration of HUVEC was evaluated by wound healing assay. Results: The percentage of F4/80 + CD86 + macrophages was significantly elevated by the transfection of shRNA, accompanied by a significantly upregulated expression of CD86 and iNOS. After the stimulation of LPS and IFN- γ , CD86 and iNOS was dramatically upregulated in both the Lv-NC group and Lv-shVEGFR1 group. IL-6 and iNOS levels were greatly declined in macrophages co-treated with LPS, IFN- γ , and PIGF. No marked alterations on the healing degree were noticed in HUVEC stimulated by the supernatant of LPS/IFN- γ treated macrophages, which was dramatically declined by the knockdown of VEGFR1. Conclusion: VEGFR1 facilitated the effect of macrophages on HUVEC migration by regulating the M1 polarization." @default.
- W4361765568 created "2023-04-04" @default.
- W4361765568 creator A5030866090 @default.
- W4361765568 creator A5042387719 @default.
- W4361765568 creator A5061130250 @default.
- W4361765568 creator A5078651920 @default.
- W4361765568 date "2022-12-01" @default.
- W4361765568 modified "2023-10-15" @default.
- W4361765568 title "Vascular Endothelial Growth Factor Receptor 1 Facilitates the Effect of Macrophages on Human Umbilical Vein Endothelial Cells Migration by Regulating the M1 Polarization" @default.
- W4361765568 cites W1817433628 @default.
- W4361765568 cites W2018125124 @default.
- W4361765568 cites W2076901405 @default.
- W4361765568 cites W2081402974 @default.
- W4361765568 cites W2298390590 @default.
- W4361765568 cites W2969880370 @default.
- W4361765568 cites W2981934626 @default.
- W4361765568 cites W2995436087 @default.
- W4361765568 doi "https://doi.org/10.1166/jbn.2022.3469" @default.
- W4361765568 hasPublicationYear "2022" @default.
- W4361765568 type Work @default.
- W4361765568 citedByCount "0" @default.
- W4361765568 crossrefType "journal-article" @default.
- W4361765568 hasAuthorship W4361765568A5030866090 @default.
- W4361765568 hasAuthorship W4361765568A5042387719 @default.
- W4361765568 hasAuthorship W4361765568A5061130250 @default.
- W4361765568 hasAuthorship W4361765568A5078651920 @default.
- W4361765568 hasConcept C104317684 @default.
- W4361765568 hasConcept C127561419 @default.
- W4361765568 hasConcept C153911025 @default.
- W4361765568 hasConcept C167734588 @default.
- W4361765568 hasConcept C173396325 @default.
- W4361765568 hasConcept C17991360 @default.
- W4361765568 hasConcept C185592680 @default.
- W4361765568 hasConcept C190232843 @default.
- W4361765568 hasConcept C190283241 @default.
- W4361765568 hasConcept C202751555 @default.
- W4361765568 hasConcept C203014093 @default.
- W4361765568 hasConcept C2776090121 @default.
- W4361765568 hasConcept C2776682551 @default.
- W4361765568 hasConcept C2777025900 @default.
- W4361765568 hasConcept C2777411675 @default.
- W4361765568 hasConcept C2778754761 @default.
- W4361765568 hasConcept C2779244956 @default.
- W4361765568 hasConcept C2781101188 @default.
- W4361765568 hasConcept C502942594 @default.
- W4361765568 hasConcept C54009773 @default.
- W4361765568 hasConcept C553184892 @default.
- W4361765568 hasConcept C55493867 @default.
- W4361765568 hasConcept C86803240 @default.
- W4361765568 hasConcept C8891405 @default.
- W4361765568 hasConceptScore W4361765568C104317684 @default.
- W4361765568 hasConceptScore W4361765568C127561419 @default.
- W4361765568 hasConceptScore W4361765568C153911025 @default.
- W4361765568 hasConceptScore W4361765568C167734588 @default.
- W4361765568 hasConceptScore W4361765568C173396325 @default.
- W4361765568 hasConceptScore W4361765568C17991360 @default.
- W4361765568 hasConceptScore W4361765568C185592680 @default.
- W4361765568 hasConceptScore W4361765568C190232843 @default.
- W4361765568 hasConceptScore W4361765568C190283241 @default.
- W4361765568 hasConceptScore W4361765568C202751555 @default.
- W4361765568 hasConceptScore W4361765568C203014093 @default.
- W4361765568 hasConceptScore W4361765568C2776090121 @default.
- W4361765568 hasConceptScore W4361765568C2776682551 @default.
- W4361765568 hasConceptScore W4361765568C2777025900 @default.
- W4361765568 hasConceptScore W4361765568C2777411675 @default.
- W4361765568 hasConceptScore W4361765568C2778754761 @default.
- W4361765568 hasConceptScore W4361765568C2779244956 @default.
- W4361765568 hasConceptScore W4361765568C2781101188 @default.
- W4361765568 hasConceptScore W4361765568C502942594 @default.
- W4361765568 hasConceptScore W4361765568C54009773 @default.
- W4361765568 hasConceptScore W4361765568C553184892 @default.
- W4361765568 hasConceptScore W4361765568C55493867 @default.
- W4361765568 hasConceptScore W4361765568C86803240 @default.
- W4361765568 hasConceptScore W4361765568C8891405 @default.
- W4361765568 hasIssue "12" @default.
- W4361765568 hasLocation W43617655681 @default.
- W4361765568 hasOpenAccess W4361765568 @default.
- W4361765568 hasPrimaryLocation W43617655681 @default.
- W4361765568 hasRelatedWork W1979107417 @default.
- W4361765568 hasRelatedWork W2001572884 @default.
- W4361765568 hasRelatedWork W2011090644 @default.
- W4361765568 hasRelatedWork W2119792638 @default.
- W4361765568 hasRelatedWork W2125881252 @default.
- W4361765568 hasRelatedWork W2157727601 @default.
- W4361765568 hasRelatedWork W2349859203 @default.
- W4361765568 hasRelatedWork W2373444340 @default.
- W4361765568 hasRelatedWork W2379904974 @default.
- W4361765568 hasRelatedWork W3024221292 @default.
- W4361765568 hasVolume "18" @default.
- W4361765568 isParatext "false" @default.
- W4361765568 isRetracted "false" @default.
- W4361765568 workType "article" @default.