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• W4361814023 abstract "<div>AbstractPurpose:<p>We performed a NCI-sponsored, prospective study of neoadjuvant FOLFIRINOX followed by chemoradiation with carboplatin/paclitaxel followed by surgery in patients with locally advanced gastric or gastroesophageal cancer.</p>Patients and Methods:<p>The primary objective was to determine completion rate of neoadjuvant FOLFIRINOX × 8 followed by chemoradiation. Secondary endpoints were toxicity and pathologic complete response (pCR) rate. Exploratory analysis was performed of circulating tumor DNA (ctDNA) to treatment response.</p>Results:<p>From October 2017 to June 2018, 25 patients were enrolled. All patients started FOLFIRINOX, 92% completed all eight planned cycles, and 88% completed chemoradiation. Twenty (80%) patients underwent surgical resection, and 7 had a pCR (35% in resected cohort, 28% intention to treat). Tumor-specific mutations were identified in 21 (84%) patients, of whom 4 and 17 patients had undetectable and detectable ctDNA at baseline, respectively. Presence of detectable post-chemoradiation ctDNA (<i>P</i> = 0.004) and/or postoperative ctDNA (<i>P</i> = 0.045) were associated with disease recurrence.</p>Conclusions:<p>Here we show neoadjuvant FOLFIRINOX followed by chemoradiation for locally advanced gastroesophageal cancer is feasible and yields a high rate of pCR. ctDNA appears to be a promising predictor of postoperative recurrence.</p><p><i>See related commentary by Catenacci, p. 6281</i></p></div>" @default.
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• W4361814023 date "2023-03-31" @default.
• W4361814023 modified "2023-10-18" @default.
• W4361814023 title "Data from Results and Molecular Correlates from a Pilot Study of Neoadjuvant Induction FOLFIRINOX Followed by Chemoradiation and Surgery for Gastroesophageal Adenocarcinomas" @default.
• W4361814023 doi "https://doi.org/10.1158/1078-0432.c.6531324.v1" @default.
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