FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361815420> ?p ?o ?g. }

• W4361815420 abstract "<div>AbstractPurpose:<p>Young age at breast cancer diagnosis correlates with unfavorable clinicopathologic features and worse outcomes compared with older women. Understanding biological differences between breast tumors in young versus older women may lead to better therapeutic approaches for younger patients.</p>Experimental Design:<p>We identified 100 patients ≤35 years old at nonmetastatic breast cancer diagnosis who participated in the prospective Young Women's Breast Cancer Study cohort. Tumors were assigned a surrogate intrinsic subtype based on receptor status and grade. Whole-exome sequencing of tumor and germline samples was performed. Genomic alterations were compared with older women (≥45 years old) in The Cancer Genome Atlas, according to intrinsic subtype.</p>Results:<p>Ninety-three tumors from 92 patients were successfully sequenced. Median age was 32.5 years; 52.7% of tumors were hormone receptor-positive/HER2-negative, 28.0% HER2-positive, and 16.1% triple-negative. Comparison of young to older women (median age 61 years) with luminal A tumors (<i>N</i> = 28 young women) revealed three significant differences: <i>PIK3CA</i> alterations were more common in older patients, whereas <i>GATA3</i> and <i>ARID1A</i> alterations were more common in young patients. No significant genomic differences were found comparing age groups in other intrinsic subtypes. Twenty-two patients (23.9%) in the Young Women's Study cohort carried a pathogenic germline variant, most commonly (13 patients, 14.1%) in <i>BRCA1/2.</i></p>Conclusions:<p>Somatic alterations in three genes (<i>PIK3CA, GATA3</i>, and <i>ARID1A</i>) occur at different frequencies in young versus older women with luminal A breast cancer. Additional investigation of these genes and associated pathways could delineate biological susceptibilities and improve treatment options for young patients with breast cancer.</p><p><i>See related commentary by Yehia and Eng, p. 2209</i></p></div>" @default.
• W4361815420 created "2023-04-05" @default.
• W4361815420 creator A5001562050 @default.
• W4361815420 creator A5007328162 @default.
• W4361815420 creator A5010075419 @default.
• W4361815420 creator A5010429902 @default.
• W4361815420 creator A5010658926 @default.
• W4361815420 creator A5011491566 @default.
• W4361815420 creator A5024392666 @default.
• W4361815420 creator A5024543136 @default.
• W4361815420 creator A5027044033 @default.
• W4361815420 creator A5034830236 @default.
• W4361815420 creator A5039694693 @default.
• W4361815420 creator A5049212930 @default.
• W4361815420 creator A5060188343 @default.
• W4361815420 creator A5063493321 @default.
• W4361815420 creator A5064031188 @default.
• W4361815420 creator A5068721624 @default.
• W4361815420 creator A5088232181 @default.
• W4361815420 creator A5089866079 @default.
• W4361815420 creator A5025041221 @default.
• W4361815420 date "2023-03-31" @default.
• W4361815420 modified "2023-09-27" @default.
• W4361815420 title "Data from Somatic and Germline Genomic Alterations in Very Young Women with Breast Cancer" @default.
• W4361815420 doi "https://doi.org/10.1158/1078-0432.c.6530813" @default.
• W4361815420 hasPublicationYear "2023" @default.
• W4361815420 type Work @default.
• W4361815420 citedByCount "0" @default.
• W4361815420 crossrefType "posted-content" @default.
• W4361815420 hasAuthorship W4361815420A5001562050 @default.
• W4361815420 hasAuthorship W4361815420A5007328162 @default.
• W4361815420 hasAuthorship W4361815420A5010075419 @default.
• W4361815420 hasAuthorship W4361815420A5010429902 @default.
• W4361815420 hasAuthorship W4361815420A5010658926 @default.
• W4361815420 hasAuthorship W4361815420A5011491566 @default.
• W4361815420 hasAuthorship W4361815420A5024392666 @default.
• W4361815420 hasAuthorship W4361815420A5024543136 @default.
• W4361815420 hasAuthorship W4361815420A5025041221 @default.
• W4361815420 hasAuthorship W4361815420A5027044033 @default.
• W4361815420 hasAuthorship W4361815420A5034830236 @default.
• W4361815420 hasAuthorship W4361815420A5039694693 @default.
• W4361815420 hasAuthorship W4361815420A5049212930 @default.
• W4361815420 hasAuthorship W4361815420A5060188343 @default.
• W4361815420 hasAuthorship W4361815420A5063493321 @default.
• W4361815420 hasAuthorship W4361815420A5064031188 @default.
• W4361815420 hasAuthorship W4361815420A5068721624 @default.
• W4361815420 hasAuthorship W4361815420A5088232181 @default.
• W4361815420 hasAuthorship W4361815420A5089866079 @default.
• W4361815420 hasBestOaLocation W43618154202 @default.
• W4361815420 hasConcept C104317684 @default.
• W4361815420 hasConcept C109825262 @default.
• W4361815420 hasConcept C121608353 @default.
• W4361815420 hasConcept C126322002 @default.
• W4361815420 hasConcept C143998085 @default.
• W4361815420 hasConcept C16671776 @default.
• W4361815420 hasConcept C188816634 @default.
• W4361815420 hasConcept C205545832 @default.
• W4361815420 hasConcept C501734568 @default.
• W4361815420 hasConcept C530470458 @default.
• W4361815420 hasConcept C54355233 @default.
• W4361815420 hasConcept C71924100 @default.
• W4361815420 hasConcept C72563966 @default.
• W4361815420 hasConcept C86803240 @default.
• W4361815420 hasConceptScore W4361815420C104317684 @default.
• W4361815420 hasConceptScore W4361815420C109825262 @default.
• W4361815420 hasConceptScore W4361815420C121608353 @default.
• W4361815420 hasConceptScore W4361815420C126322002 @default.
• W4361815420 hasConceptScore W4361815420C143998085 @default.
• W4361815420 hasConceptScore W4361815420C16671776 @default.
• W4361815420 hasConceptScore W4361815420C188816634 @default.
• W4361815420 hasConceptScore W4361815420C205545832 @default.
• W4361815420 hasConceptScore W4361815420C501734568 @default.
• W4361815420 hasConceptScore W4361815420C530470458 @default.
• W4361815420 hasConceptScore W4361815420C54355233 @default.
• W4361815420 hasConceptScore W4361815420C71924100 @default.
• W4361815420 hasConceptScore W4361815420C72563966 @default.
• W4361815420 hasConceptScore W4361815420C86803240 @default.
• W4361815420 hasLocation W43618154201 @default.
• W4361815420 hasLocation W43618154202 @default.
• W4361815420 hasOpenAccess W4361815420 @default.
• W4361815420 hasPrimaryLocation W43618154201 @default.
• W4361815420 hasRelatedWork W1932411143 @default.
• W4361815420 hasRelatedWork W1945350395 @default.
• W4361815420 hasRelatedWork W1972240813 @default.
• W4361815420 hasRelatedWork W3010237090 @default.
• W4361815420 hasRelatedWork W3082483787 @default.
• W4361815420 hasRelatedWork W3112166790 @default.
• W4361815420 hasRelatedWork W377899687 @default.
• W4361815420 hasRelatedWork W4226272961 @default.
• W4361815420 hasRelatedWork W753187385 @default.
• W4361815420 hasRelatedWork W2100228880 @default.
• W4361815420 isParatext "false" @default.
• W4361815420 isRetracted "false" @default.
• W4361815420 workType "article" @default.