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- W4361815900 abstract "<div>Abstract<p>Entire or partial deletions of the male-specific Y chromosome are associated with tumorigenesis, but whether any male-specific genes located on this chromosome play a tumor-suppressive role is unknown. Here, we report that the histone H3 lysine 4 (H3K4) demethylase JARID1D (also called KDM5D and SMCY), a male-specific protein, represses gene expression programs associated with cell invasiveness and suppresses the invasion of prostate cancer cells <i>in vitro</i> and <i>in vivo</i>. We found that JARID1D specifically repressed the invasion-associated genes <i>MMP1</i>, <i>MMP2</i>, <i>MMP3</i>, <i>MMP7</i>, and Slug by demethylating trimethyl H3K4, a gene-activating mark, at their promoters. Our additional results demonstrated that JARID1D levels were highly downregulated in metastatic prostate tumors compared with normal prostate tissues and primary prostate tumors. Furthermore, the <i>JARID1D</i> gene was frequently deleted in metastatic prostate tumors, and low JARID1D levels were associated with poor prognosis in prostate cancer patients. Taken together, these findings provide the first evidence that an epigenetic modifier expressed on the Y chromosome functions as an anti-invasion factor to suppress the progression of prostate cancer. Our results also highlight a preclinical rationale for using JARID1D as a prognostic marker in advanced prostate cancer. <i>Cancer Res; 76(4); 831–43. ©2016 AACR</i>.</p></div>" @default.
- W4361815900 created "2023-04-05" @default.
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- W4361815900 date "2023-03-30" @default.
- W4361815900 modified "2023-09-24" @default.
- W4361815900 title "Data from JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis" @default.
- W4361815900 doi "https://doi.org/10.1158/0008-5472.c.6507908" @default.
- W4361815900 hasPublicationYear "2023" @default.
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