FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361816827> ?p ?o ?g. }

• W4361816827 abstract "<div>Abstract<p><b>Background:</b> The incidence of acute lymphoblastic leukemia (ALL) is nearly 20% higher among Hispanics than non-Hispanic Whites. Previous studies have shown evidence for association between risk of ALL and variation within <i>IKZF1, ARID5B, CEBPE, CDKN2A, GATA3</i>, and <i>BM1-PIP4K2A</i> genes. However, variants identified only account for <10% of the genetic risk of ALL.</p><p><b>Methods:</b> We applied pathway-based analyses to genome-wide association study (GWAS) data from the California Childhood Leukemia Study to determine whether different biologic pathways were overrepresented in childhood ALL and major ALL subtypes. Furthermore, we applied causal inference and data reduction methods to prioritize candidate genes within each identified overrepresented pathway, while accounting for correlation among SNPs.</p><p><b>Results:</b> Pathway analysis results indicate that different ALL subtypes may involve distinct biologic mechanisms. Focal adhesion is a shared mechanism across the different disease subtypes. For ALL, the top five overrepresented Kyoto Encyclopedia of Genes and Genomes pathways include axon guidance, protein digestion and absorption, melanogenesis, leukocyte transendothelial migration, and focal adhesion (<i>P</i>_FDR < 0.05). Notably, these pathways are connected to downstream <i>MAPK</i> or <i>Wnt</i> signaling pathways which have been linked to B-cell malignancies. Several candidate genes for ALL, such as <i>COL6A6</i> and <i>COL5A1</i>, were identified through targeted maximum likelihood estimation.</p><p><b>Conclusions:</b> This is the first study to show distinct biologic pathways are overrepresented in different ALL subtypes using pathway-based approaches, and identified potential gene candidates using causal inference methods.</p><p><b>Impact:</b> The findings demonstrate that newly developed bioinformatics tools and causal inference methods can provide insights to furthering our understanding of the pathogenesis of leukemia. <i>Cancer Epidemiol Biomarkers Prev; 25(5); 815–22. ©2016 AACR</i>.</p></div>" @default.
• W4361816827 created "2023-04-05" @default.
• W4361816827 creator A5020203591 @default.
• W4361816827 creator A5030408366 @default.
• W4361816827 creator A5043076766 @default.
• W4361816827 creator A5059955772 @default.
• W4361816827 creator A5061633563 @default.
• W4361816827 creator A5078899376 @default.
• W4361816827 creator A5081625019 @default.
• W4361816827 date "2023-03-31" @default.
• W4361816827 modified "2023-09-24" @default.
• W4361816827 title "Data from Pathway Analysis of Genome-wide Association Study in Childhood Leukemia among Hispanics" @default.
• W4361816827 doi "https://doi.org/10.1158/1055-9965.c.6515548" @default.
• W4361816827 hasPublicationYear "2023" @default.
• W4361816827 type Work @default.
• W4361816827 citedByCount "0" @default.
• W4361816827 crossrefType "posted-content" @default.
• W4361816827 hasAuthorship W4361816827A5020203591 @default.
• W4361816827 hasAuthorship W4361816827A5030408366 @default.
• W4361816827 hasAuthorship W4361816827A5043076766 @default.
• W4361816827 hasAuthorship W4361816827A5059955772 @default.
• W4361816827 hasAuthorship W4361816827A5061633563 @default.
• W4361816827 hasAuthorship W4361816827A5078899376 @default.
• W4361816827 hasAuthorship W4361816827A5081625019 @default.
• W4361816827 hasConcept C104317684 @default.
• W4361816827 hasConcept C106208931 @default.
• W4361816827 hasConcept C135763542 @default.
• W4361816827 hasConcept C137620995 @default.
• W4361816827 hasConcept C153209595 @default.
• W4361816827 hasConcept C186413461 @default.
• W4361816827 hasConcept C54355233 @default.
• W4361816827 hasConcept C71924100 @default.
• W4361816827 hasConcept C86803240 @default.
• W4361816827 hasConceptScore W4361816827C104317684 @default.
• W4361816827 hasConceptScore W4361816827C106208931 @default.
• W4361816827 hasConceptScore W4361816827C135763542 @default.
• W4361816827 hasConceptScore W4361816827C137620995 @default.
• W4361816827 hasConceptScore W4361816827C153209595 @default.
• W4361816827 hasConceptScore W4361816827C186413461 @default.
• W4361816827 hasConceptScore W4361816827C54355233 @default.
• W4361816827 hasConceptScore W4361816827C71924100 @default.
• W4361816827 hasConceptScore W4361816827C86803240 @default.
• W4361816827 hasLocation W43618168271 @default.
• W4361816827 hasOpenAccess W4361816827 @default.
• W4361816827 hasPrimaryLocation W43618168271 @default.
• W4361816827 hasRelatedWork W2077708857 @default.
• W4361816827 hasRelatedWork W2145474755 @default.
• W4361816827 hasRelatedWork W2169993638 @default.
• W4361816827 hasRelatedWork W2589043292 @default.
• W4361816827 hasRelatedWork W2730428919 @default.
• W4361816827 hasRelatedWork W286307657 @default.
• W4361816827 hasRelatedWork W2884987722 @default.
• W4361816827 hasRelatedWork W2953466646 @default.
• W4361816827 hasRelatedWork W4205545748 @default.
• W4361816827 hasRelatedWork W4221011317 @default.
• W4361816827 isParatext "false" @default.
• W4361816827 isRetracted "false" @default.
• W4361816827 workType "article" @default.