FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361818096> ?p ?o ?g. }

• W4361818096 abstract "<div>Abstract<p><b>Purpose:</b> <i>LKB1</i> loss is common in lung cancer, but no assay exists to efficiently evaluate the presence or absence of LKB1. We validated an IHC assay for LKB1 loss and determined the impact of LKB1 loss in <i>KRAS</i>-mutant non–small cell lung cancer (NSCLC).</p><p><b>Experimental Design:</b> We optimized and validated an IHC assay for LKB1 (clone Ley37D/G6) using a panel of lung cancer cell lines and tumors with known <i>LKB1</i> mutations, including 2 patients with Peutz–Jeghers syndrome (PJS) who developed lung adenocarcinoma. We retrospectively analyzed tumors for LKB1 using IHC from 154 <i>KRAS</i>-mutant NSCLC patients, including 123 smokers and 31 never-smokers, and correlated the findings with patient and tumor characteristics and clinical outcome.</p><p><b>Results:</b> LKB1 expression was lost by IHC in 30% of <i>KRAS</i>-mutant NSCLC (smokers 35% vs. never-smokers 13%, <i>P</i> = 0.017). LKB1 loss did not correlate with a specific <i>KRAS</i> mutation but was more frequent in tumors with <i>KRAS</i> transversion mutations (<i>P</i> = 0.029). <i>KRAS</i>-mutant NSCLC patients with concurrent LKB1 loss had a higher number of metastatic sites at the time of diagnosis (median 2.5 vs. 2, <i>P</i> = 0.01), higher incidence of extrathoracic metastases (<i>P</i> = 0.01), and developed brain metastasis more frequently (48% vs. 25%, <i>P</i> = 0.02). There was a nonsignificant trend to worse survival in stage IV <i>KRAS</i>-mutant NSCLC patients with LKB1 loss.</p><p><b>Conclusions:</b> LKB1 IHC is a reliable and efficient assay to evaluate for loss of <i>LKB1</i> in clinical samples of NSCLC. LKB1 loss is more common in smokers, and is associated with a more aggressive clinical phenotype in <i>KRAS</i>-mutant NSCLC patients, accordingly to preclinical models. <i>Clin Cancer Res; 21(12); 2851–60. ©2015 AACR</i>.</p></div>" @default.
• W4361818096 created "2023-04-05" @default.
• W4361818096 creator A5016929439 @default.
• W4361818096 creator A5028909262 @default.
• W4361818096 creator A5045665778 @default.
• W4361818096 creator A5048675362 @default.
• W4361818096 creator A5058817845 @default.
• W4361818096 creator A5058975989 @default.
• W4361818096 creator A5071877659 @default.
• W4361818096 creator A5078692060 @default.
• W4361818096 creator A5079599874 @default.
• W4361818096 creator A5090452503 @default.
• W4361818096 creator A5090956629 @default.
• W4361818096 date "2023-03-31" @default.
• W4361818096 modified "2023-10-17" @default.
• W4361818096 title "Data from Immunohistochemical Loss of LKB1 Is a Biomarker for More Aggressive Biology in <i>KRAS</i>-Mutant Lung Adenocarcinoma" @default.
• W4361818096 doi "https://doi.org/10.1158/1078-0432.c.6524763.v1" @default.
• W4361818096 hasPublicationYear "2023" @default.
• W4361818096 type Work @default.
• W4361818096 citedByCount "0" @default.
• W4361818096 crossrefType "posted-content" @default.
• W4361818096 hasAuthorship W4361818096A5016929439 @default.
• W4361818096 hasAuthorship W4361818096A5028909262 @default.
• W4361818096 hasAuthorship W4361818096A5045665778 @default.
• W4361818096 hasAuthorship W4361818096A5048675362 @default.
• W4361818096 hasAuthorship W4361818096A5058817845 @default.
• W4361818096 hasAuthorship W4361818096A5058975989 @default.
• W4361818096 hasAuthorship W4361818096A5071877659 @default.
• W4361818096 hasAuthorship W4361818096A5078692060 @default.
• W4361818096 hasAuthorship W4361818096A5079599874 @default.
• W4361818096 hasAuthorship W4361818096A5090452503 @default.
• W4361818096 hasAuthorship W4361818096A5090956629 @default.
• W4361818096 hasConcept C121608353 @default.
• W4361818096 hasConcept C126322002 @default.
• W4361818096 hasConcept C204232928 @default.
• W4361818096 hasConcept C2776256026 @default.
• W4361818096 hasConcept C2781182431 @default.
• W4361818096 hasConcept C2781187634 @default.
• W4361818096 hasConcept C502942594 @default.
• W4361818096 hasConcept C526805850 @default.
• W4361818096 hasConcept C71924100 @default.
• W4361818096 hasConceptScore W4361818096C121608353 @default.
• W4361818096 hasConceptScore W4361818096C126322002 @default.
• W4361818096 hasConceptScore W4361818096C204232928 @default.
• W4361818096 hasConceptScore W4361818096C2776256026 @default.
• W4361818096 hasConceptScore W4361818096C2781182431 @default.
• W4361818096 hasConceptScore W4361818096C2781187634 @default.
• W4361818096 hasConceptScore W4361818096C502942594 @default.
• W4361818096 hasConceptScore W4361818096C526805850 @default.
• W4361818096 hasConceptScore W4361818096C71924100 @default.
• W4361818096 hasLocation W43618180961 @default.
• W4361818096 hasOpenAccess W4361818096 @default.
• W4361818096 hasPrimaryLocation W43618180961 @default.
• W4361818096 hasRelatedWork W1606053986 @default.
• W4361818096 hasRelatedWork W1967429227 @default.
• W4361818096 hasRelatedWork W2149655775 @default.
• W4361818096 hasRelatedWork W2164155795 @default.
• W4361818096 hasRelatedWork W2374390921 @default.
• W4361818096 hasRelatedWork W2530471001 @default.
• W4361818096 hasRelatedWork W3156716706 @default.
• W4361818096 hasRelatedWork W4306643401 @default.
• W4361818096 hasRelatedWork W4361253018 @default.
• W4361818096 hasRelatedWork W2140890293 @default.
• W4361818096 isParatext "false" @default.
• W4361818096 isRetracted "false" @default.
• W4361818096 workType "article" @default.