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- W4361818995 abstract "<div>Abstract<p>Bacterial infection is linked to colorectal carcinogenesis, but the species that contribute to a protumorigenic ecology are ill-defined. Here we report evidence that α-hemolysin–positive (<i>hly</i><sup>+</sup>) type I <i>Escherichia coli</i> (<i>E. coli</i>) drives adenomagenesis and colorectal cancer in human females but not males. We classified <i>E. coli</i> into four types using a novel typing method to monitor fimH mutation patterns of fecal isolates from adenoma patients (<i>n</i>= 59), colorectal cancer patients (<i>n</i>= 83), and healthy subjects (<i>n</i>= 85). <i>hly</i><sup>+</sup> type I <i>E. coli</i> was found to be relatively more prevalent in stools from females with adenoma and colorectal cancer, correlating with poor survival in colorectal cancer patients. In mechanistic studies in female mice, we found that <i>hly</i><sup>+</sup> type 1 <i>E. coli</i> activated expression of the glucose transporter GLUT1 and repressed expression of the tumor suppressor BIM. <i>hly</i>-encoded alpha hemolysin partially accounted for these effects by elevating the levels of HIF1α. Notably, colon tumorigenesis in mice could be promoted by feeding <i>hly</i><sup>+</sup> type I <i>E. coli</i> to female but not male subjects. Collectively, our findings point to hemolytic type I <i>E. coli</i> as a candidate causative factor of colorectal cancer in human females, with additional potential as a biomarker of disease susceptibility. <i>Cancer Res; 76(10); 2891–900. ©2016 AACR</i>.</p></div>" @default.
- W4361818995 created "2023-04-05" @default.
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- W4361818995 date "2023-03-30" @default.
- W4361818995 modified "2023-09-26" @default.
- W4361818995 title "Data from Hemolytic <i>E. coli</i> Promotes Colonic Tumorigenesis in Females" @default.
- W4361818995 doi "https://doi.org/10.1158/0008-5472.c.6507798.v1" @default.
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