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• W4361821810 abstract "<div>Abstract<p><b>Background:</b> The matrix metalloproteinases (MMP) cause degradation of the extracellular matrix and basement membranes, and thus may play a key role in cancer development.</p><p><b>Methods:</b> In our search for biomarkers for oral squamous cell carcinomas (OSCC), we compared primary OSCC, oral dysplasia and control subjects with respect to: (i) expression of <i>MMP1</i>, <i>MMP3</i>, <i>MMP10</i>, and <i>MMP12</i> in oral epithelial tissue using Affymetrix U133 2.0 Plus GeneChip arrays, followed by quantitative reverse transcription-PCR (qRT-PCR) for <i>MMP1</i>, and (ii) determination of MMP1 and MMP3 concentrations in saliva.</p><p><b>Results:</b><i>MMP1</i> expression in primary OSCC (<i>n</i> = 119) was >200-fold higher (<i>P</i> = 7.16 × 10⁻⁴⁰) compared with expression levels in nonneoplastic oral epithelium from controls (<i>n</i> = 35). qRT-PCR results on 30 cases and 22 controls confirmed this substantial differential expression. The exceptional discriminatory power to separate OSCC from controls was validated in two independent testing sets (AUC% = 100; 95% CI: 100–100 and AUC% = 98.4; 95% CI: 95.6–100). Salivary concentrations of MMP1 and MMP3 in OSCC patients (33 stage I/II, 26 stage III/IV) were 6.2 times (95% CI: 3.32–11.73) and 14.8 times (95% CI: 6.75–32.56) higher, respectively, than in controls, and displayed an increasing trend with higher stage disease.</p><p><b>Conclusion:</b> Tumor and salivary MMPs are robust diagnostic biomarkers of OSCC.</p><p><b>Impact:</b> The capacity of MMP gene expression to identify OSCC provides support for further investigation into MMPs as potential markers for OSCC development. Detection of MMP proteins in saliva in particular may provide a promising means to detect and monitor OSCC noninvasively. <i>Cancer Epidemiol Biomarkers Prev; 20(12); 2628–36. ©2011 AACR</i>.</p></div>" @default.
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• W4361821810 date "2023-03-31" @default.
• W4361821810 modified "2023-09-23" @default.
• W4361821810 title "Data from Tumor and Salivary Matrix Metalloproteinase Levels Are Strong Diagnostic Markers of Oral Squamous Cell Carcinoma" @default.
• W4361821810 doi "https://doi.org/10.1158/1055-9965.c.6514998" @default.
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