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• W4361822014 abstract "<div>Abstract<p><b>Background</b>: Genome-wide association studies have identified multiple genetic variants associated with susceptibility to prostate cancer (PrCa). In the two-stage Cancer Genetic Markers of Susceptibility prostate cancer scan, a single-nucleotide polymorphism (SNP), rs10486567, located within intron 2 of <i>JAZF1</i> gene on chromosome 7p15.2, showed a promising association with PrCa overall (<i>P</i> = 2.14 × 10⁻⁶), with a suggestion of stronger association with aggressive disease (<i>P</i> = 1.2 × 10⁻⁷).</p><p><b>Methods</b>: In the third stage of genome-wide association studies, we genotyped 106 <i>JAZF1</i> SNPs in 10,286 PrCa cases and 9,135 controls of European ancestry.</p><p><b>Results</b>: The strongest association was observed with the initial marker rs10486567, which now achieves genome-wide significance [<i>P</i> = 7.79 × 10⁻¹¹; OR_HET, 1.19 (95% confidence interval, 1.12-1.27); OR_HOM, 1.37 (95% confidence interval, 1.20-1.56)]. We did not confirm a previous suggestion of a stronger association of rs10486567 with aggressive disease (<i>P</i> = 1.60 × 10⁻⁴ for aggressive cancer, <i>n</i> = 4,597; <i>P</i> = 3.25 × 10⁻⁸ for nonaggressive cancer, <i>n</i> = 4,514). Based on a multilocus model with adjustment for rs10486567, no additional independent signals were observed at chromosome 7p15.2. There was no association between PrCa risk and SNPs in <i>JAZF1</i> previously associated with height (rs849140; <i>P</i> = 0.587), body stature (rs849141, tagged by rs849136; <i>P</i> = 0.171), and risk of type 2 diabetes and systemic lupus erythematosus (rs864745, tagged by rs849142; <i>P</i> = 0.657).</p><p><b>Conclusion</b>: rs10486567 remains the most significant marker for PrCa risk within <i>JAZF1</i> in individuals of European ancestry.</p><p><b>Impact</b>: Future studies should identify all variants in high linkage disequilibrium with rs10486567 and evaluate their functional significance for PrCa. Cancer Epidemiol Biomarkers Prev; 19(5); 1349–55. ©2010 AACR.</p></div>" @default.
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• W4361822014 date "2023-03-31" @default.
• W4361822014 modified "2023-10-18" @default.
• W4361822014 title "Data from Refining the Prostate Cancer Genetic Association within the <i>JAZF1</i> Gene on Chromosome 7p15.2" @default.
• W4361822014 doi "https://doi.org/10.1158/1055-9965.c.6514884.v1" @default.
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