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- W4361823536 abstract "<div>Abstract<p>Inflammation and microbiota are critical components of intestinal tumorigenesis. To dissect how the microbiota contributes to tumor distribution, we generated germ-free (GF) <i>Apc<sup>Min/+</sup></i>and <i>Apc<sup>Min/+</sup></i>;<i>Il10<sup>−/−</sup></i> mice and exposed them to specific-pathogen-free (SPF) or colorectal cancer-associated bacteria. We found that colon tumorigenesis significantly correlated with inflammation in SPF-housed <i>Apc<sup>Min/+</sup></i>;<i>Il10<sup>−/−</sup></i>, but not in <i>Apc<sup>Min/+</sup></i>mice. In contrast, small intestinal neoplasia development significantly correlated with age in both <i>Apc<sup>Min/+</sup></i>;<i>Il10<sup>−/−</sup></i> and <i>Apc<sup>Min/+</sup></i> mice. GF <i>Apc<sup>Min/+</sup></i>;<i>Il10<sup>−/−</sup></i> mice conventionalized by an SPF microbiota had significantly more colon tumors compared with GF mice. Gnotobiotic studies revealed that while <i>Fusobacterium nucleatum</i> clinical isolates with FadA and Fap2 adhesins failed to induce inflammation and tumorigenesis, <i>pks</i><sup>+</sup><i>Escherichia coli</i> promoted tumorigenesis in the <i>Apc<sup>Min/+</sup></i>;<i>Il10<sup>−/−</sup></i> model in a colibactin-dependent manner, suggesting colibactin is a driver of carcinogenesis. Our results suggest a distinct etiology of cancers in different locations of the gut, where colon cancer is primarily driven by inflammation and the microbiome, while age is a driving force for small intestine cancer. <i>Cancer Res; 77(10); 2620–32. ©2017 AACR</i>.</p></div>" @default.
- W4361823536 created "2023-04-05" @default.
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- W4361823536 date "2023-03-31" @default.
- W4361823536 modified "2023-09-28" @default.
- W4361823536 title "Data from Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis" @default.
- W4361823536 doi "https://doi.org/10.1158/0008-5472.c.6508515.v1" @default.
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