Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361823634> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4361823634 abstract "<div>Abstract<p>Invadopodia are ventral membrane protrusions through which invasive cancer cells degrade the extracellular matrix. They are thought to function in the migration of cancer cells through tissue barriers, which is necessary for cancer invasion and metastasis. Although many protein components of invadopodia have been identified, the organization and the role of membrane lipids in invadopodia are not well understood. In this study, the role of lipid rafts, which are cholesterol-enriched membrane microdomains, in the assembly and function of invadopodia in human breast cancer cells was investigated. Lipid rafts are enriched, internalized, and dynamically trafficked at invadopodia sites. Perturbation of lipid raft formation due to depleting or sequestering membrane cholesterol blocked the invadopodia-mediated degradation of the gelatin matrix. Caveolin-1 (Cav-1), a resident protein of lipid rafts and caveolae, accumulates at invadopodia and colocalizes with the internalized lipid raft membranes. Membrane type 1 matrix metalloproteinase (MT1-MMP), a matrix proteinase associated with invadopodia, is localized at lipid raft-enriched membrane fractions and cotrafficked and colocalized with Cav-1 at invadopodia. The small interfering RNA–mediated silencing of Cav-1 inhibited the invadopodia-mediated and MT1-MMP–dependent degradation of the gelatin matrix. Furthermore, Cav-1 and MT1-MMP are coexpressed in invasive human breast cancer cell lines that have an ability to form invadopodia. These results indicate that invadopodia are the sites where enrichment and trafficking of lipid rafts occur and that Cav-1 is an essential regulator of MT1-MMP function and invadopodia-mediated breast cancer cell invasion. [Cancer Res 2009;69(22):8594–602]</p></div>" @default.
- W4361823634 created "2023-04-05" @default.
- W4361823634 creator A5015776450 @default.
- W4361823634 creator A5048937697 @default.
- W4361823634 creator A5076679264 @default.
- W4361823634 creator A5079099200 @default.
- W4361823634 creator A5079261205 @default.
- W4361823634 creator A5084440502 @default.
- W4361823634 date "2023-03-30" @default.
- W4361823634 modified "2023-09-27" @default.
- W4361823634 title "Data from Lipid Rafts and Caveolin-1 Are Required for Invadopodia Formation and Extracellular Matrix Degradation by Human Breast Cancer Cells" @default.
- W4361823634 doi "https://doi.org/10.1158/0008-5472.c.6500484" @default.
- W4361823634 hasPublicationYear "2023" @default.
- W4361823634 type Work @default.
- W4361823634 citedByCount "0" @default.
- W4361823634 crossrefType "posted-content" @default.
- W4361823634 hasAuthorship W4361823634A5015776450 @default.
- W4361823634 hasAuthorship W4361823634A5048937697 @default.
- W4361823634 hasAuthorship W4361823634A5076679264 @default.
- W4361823634 hasAuthorship W4361823634A5079099200 @default.
- W4361823634 hasAuthorship W4361823634A5079261205 @default.
- W4361823634 hasAuthorship W4361823634A5084440502 @default.
- W4361823634 hasBestOaLocation W43618236342 @default.
- W4361823634 hasConcept C121608353 @default.
- W4361823634 hasConcept C185592680 @default.
- W4361823634 hasConcept C189165786 @default.
- W4361823634 hasConcept C200786668 @default.
- W4361823634 hasConcept C49866891 @default.
- W4361823634 hasConcept C54355233 @default.
- W4361823634 hasConcept C62478195 @default.
- W4361823634 hasConcept C79266657 @default.
- W4361823634 hasConcept C86803240 @default.
- W4361823634 hasConcept C95444343 @default.
- W4361823634 hasConcept C96232424 @default.
- W4361823634 hasConceptScore W4361823634C121608353 @default.
- W4361823634 hasConceptScore W4361823634C185592680 @default.
- W4361823634 hasConceptScore W4361823634C189165786 @default.
- W4361823634 hasConceptScore W4361823634C200786668 @default.
- W4361823634 hasConceptScore W4361823634C49866891 @default.
- W4361823634 hasConceptScore W4361823634C54355233 @default.
- W4361823634 hasConceptScore W4361823634C62478195 @default.
- W4361823634 hasConceptScore W4361823634C79266657 @default.
- W4361823634 hasConceptScore W4361823634C86803240 @default.
- W4361823634 hasConceptScore W4361823634C95444343 @default.
- W4361823634 hasConceptScore W4361823634C96232424 @default.
- W4361823634 hasLocation W43618236341 @default.
- W4361823634 hasLocation W43618236342 @default.
- W4361823634 hasOpenAccess W4361823634 @default.
- W4361823634 hasPrimaryLocation W43618236341 @default.
- W4361823634 hasRelatedWork W2057340727 @default.
- W4361823634 hasRelatedWork W2076606695 @default.
- W4361823634 hasRelatedWork W2120553481 @default.
- W4361823634 hasRelatedWork W2137628822 @default.
- W4361823634 hasRelatedWork W2163632517 @default.
- W4361823634 hasRelatedWork W2289720629 @default.
- W4361823634 hasRelatedWork W4361870630 @default.
- W4361823634 hasRelatedWork W4361870663 @default.
- W4361823634 hasRelatedWork W4361894144 @default.
- W4361823634 hasRelatedWork W72547129 @default.
- W4361823634 isParatext "false" @default.
- W4361823634 isRetracted "false" @default.
- W4361823634 workType "article" @default.