Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361823748> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4361823748 abstract "<div>Abstract<p>An effective cancer blood biomarker screening strategy must distinguish aggressive from nonaggressive tumors at an early, intervenable time. However, for blood-based strategies to be useful, the quantity of biomarker shed into the blood and its relationship to tumor growth or progression must be validated. To study how blood biomarker levels correlate with early-stage viable tumor growth in a mouse model of human cancer, we monitored early tumor growth of engineered human ovarian cancer cells (A2780) implanted orthotopically into nude mice. Biomarker shedding was monitored by serial blood sampling, whereas tumor viability and volume were monitored by bioluminescence imaging and ultrasound imaging. From these metrics, we developed a mathematical model of cancer biomarker kinetics that accounts for biomarker shedding from tumor and healthy cells, biomarker entry into vasculature, biomarker elimination from plasma, and subject-specific tumor growth. We validated the model in a separate set of mice in which subject-specific tumor growth rates were accurately predicted. To illustrate clinical translation of this strategy, we allometrically scaled model parameters from mouse to human and used parameters for PSA shedding and prostate cancer. In this manner, we found that blood biomarker sampling data alone were capable of enabling the detection and discrimination of simulated aggressive (2-month tumor doubling time) and nonaggressive (18-month tumor doubling time) tumors as early as 7.2 months and 8.9 years before clinical imaging, respectively. Our model and screening strategy offers broad impact in their applicability to any solid cancer and associated biomarkers shed, thereby allowing a distinction between aggressive and nonaggressive tumors using blood biomarker sampling data alone. <i>Cancer Res; 77(10); 2570–84. ©2017 AACR</i>.</p></div>" @default.
- W4361823748 created "2023-04-05" @default.
- W4361823748 creator A5018880989 @default.
- W4361823748 creator A5019955301 @default.
- W4361823748 creator A5076949598 @default.
- W4361823748 creator A5082883632 @default.
- W4361823748 date "2023-03-31" @default.
- W4361823748 modified "2023-10-14" @default.
- W4361823748 title "Data from A Model-Based Personalized Cancer Screening Strategy for Detecting Early-Stage Tumors Using Blood-Borne Biomarkers" @default.
- W4361823748 doi "https://doi.org/10.1158/0008-5472.c.6508670.v1" @default.
- W4361823748 hasPublicationYear "2023" @default.
- W4361823748 type Work @default.
- W4361823748 citedByCount "0" @default.
- W4361823748 crossrefType "posted-content" @default.
- W4361823748 hasAuthorship W4361823748A5018880989 @default.
- W4361823748 hasAuthorship W4361823748A5019955301 @default.
- W4361823748 hasAuthorship W4361823748A5076949598 @default.
- W4361823748 hasAuthorship W4361823748A5082883632 @default.
- W4361823748 hasConcept C121608353 @default.
- W4361823748 hasConcept C126322002 @default.
- W4361823748 hasConcept C142724271 @default.
- W4361823748 hasConcept C143998085 @default.
- W4361823748 hasConcept C146357865 @default.
- W4361823748 hasConcept C151730666 @default.
- W4361823748 hasConcept C2779013556 @default.
- W4361823748 hasConcept C2780192828 @default.
- W4361823748 hasConcept C2781197716 @default.
- W4361823748 hasConcept C2988731192 @default.
- W4361823748 hasConcept C502942594 @default.
- W4361823748 hasConcept C55493867 @default.
- W4361823748 hasConcept C61238886 @default.
- W4361823748 hasConcept C71924100 @default.
- W4361823748 hasConcept C86803240 @default.
- W4361823748 hasConceptScore W4361823748C121608353 @default.
- W4361823748 hasConceptScore W4361823748C126322002 @default.
- W4361823748 hasConceptScore W4361823748C142724271 @default.
- W4361823748 hasConceptScore W4361823748C143998085 @default.
- W4361823748 hasConceptScore W4361823748C146357865 @default.
- W4361823748 hasConceptScore W4361823748C151730666 @default.
- W4361823748 hasConceptScore W4361823748C2779013556 @default.
- W4361823748 hasConceptScore W4361823748C2780192828 @default.
- W4361823748 hasConceptScore W4361823748C2781197716 @default.
- W4361823748 hasConceptScore W4361823748C2988731192 @default.
- W4361823748 hasConceptScore W4361823748C502942594 @default.
- W4361823748 hasConceptScore W4361823748C55493867 @default.
- W4361823748 hasConceptScore W4361823748C61238886 @default.
- W4361823748 hasConceptScore W4361823748C71924100 @default.
- W4361823748 hasConceptScore W4361823748C86803240 @default.
- W4361823748 hasLocation W43618237481 @default.
- W4361823748 hasOpenAccess W4361823748 @default.
- W4361823748 hasPrimaryLocation W43618237481 @default.
- W4361823748 hasRelatedWork W1994395871 @default.
- W4361823748 hasRelatedWork W2105794519 @default.
- W4361823748 hasRelatedWork W2212921542 @default.
- W4361823748 hasRelatedWork W2783882412 @default.
- W4361823748 hasRelatedWork W2799933688 @default.
- W4361823748 hasRelatedWork W2895446600 @default.
- W4361823748 hasRelatedWork W2999311886 @default.
- W4361823748 hasRelatedWork W3119369239 @default.
- W4361823748 hasRelatedWork W3126290430 @default.
- W4361823748 hasRelatedWork W4318619681 @default.
- W4361823748 isParatext "false" @default.
- W4361823748 isRetracted "false" @default.
- W4361823748 workType "article" @default.