Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361823838> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4361823838 abstract "<div>Abstract<p>A subset of stem-like cells in glioblastoma (GBM; GSC) underlies tumor propagation, therapeutic resistance, and tumor recurrence. Immune evasion is critical for GSCs to carry out these functions. However, the molecular mechanisms employed by GSCs to escape antitumor immunity remain largely unknown. The reprogramming transcription factors Oct4 and Sox2 function as core multipotency factors and play an essential role in the formation and maintenance of GSCs, but the roles of these transcription factors in GSC immune escape have not been well explored. Here we examine how Oct4/Sox2 coexpression contributes to the immunosuppressive phenotype of GSCs. Combined transcription profiling and functional studies of Oct4/Sox2 coexpressing GSCs and differentiated GBM cells demonstrated that Oct4 and Sox2 cooperatively induce an immunosuppressive transcriptome consisting of multiple immunosuppressive checkpoints (i.e., PD-L1, CD70, A2aR, TDO) and dysregulation of cytokines and chemokines that are associated with an immunosuppressive tumor microenvironment. Mechanistically, induction and function of BRD/H3k27Ac-dependent immunosuppressive genes played a role in the immunosuppressive phenotype of GSCs. Pan-BET bromodomain inhibitors (e.g., JQ1) and shBRD4 constructs significantly inhibited the immunosuppressive transcriptome and immunosuppressive biological responses induced by Oct4/Sox2. Our findings identify targetable mechanisms by which tumor-propagating GSCs contribute to the immunosuppressive microenvironment in GBM.</p>Significance:<p>This report identifies mechanisms by which the reprogramming transcription factors Oct4 and Sox2 function to drive the immunomodulatory transcriptome of GSCs and contribute to the immunosuppressive microenvironment in GBM.</p></div>" @default.
- W4361823838 created "2023-04-05" @default.
- W4361823838 creator A5011340023 @default.
- W4361823838 creator A5027043430 @default.
- W4361823838 creator A5028344363 @default.
- W4361823838 creator A5029294194 @default.
- W4361823838 creator A5035964041 @default.
- W4361823838 creator A5045180153 @default.
- W4361823838 creator A5045429112 @default.
- W4361823838 creator A5055851090 @default.
- W4361823838 creator A5067025487 @default.
- W4361823838 creator A5068043303 @default.
- W4361823838 creator A5080005941 @default.
- W4361823838 date "2023-03-31" @default.
- W4361823838 modified "2023-10-16" @default.
- W4361823838 title "Data from Reprogramming Transcription Factors Oct4 and Sox2 Induce a BRD-Dependent Immunosuppressive Transcriptome in GBM-Propagating Cells" @default.
- W4361823838 doi "https://doi.org/10.1158/0008-5472.c.6513642.v1" @default.
- W4361823838 hasPublicationYear "2023" @default.
- W4361823838 type Work @default.
- W4361823838 citedByCount "0" @default.
- W4361823838 crossrefType "posted-content" @default.
- W4361823838 hasAuthorship W4361823838A5011340023 @default.
- W4361823838 hasAuthorship W4361823838A5027043430 @default.
- W4361823838 hasAuthorship W4361823838A5028344363 @default.
- W4361823838 hasAuthorship W4361823838A5029294194 @default.
- W4361823838 hasAuthorship W4361823838A5035964041 @default.
- W4361823838 hasAuthorship W4361823838A5045180153 @default.
- W4361823838 hasAuthorship W4361823838A5045429112 @default.
- W4361823838 hasAuthorship W4361823838A5055851090 @default.
- W4361823838 hasAuthorship W4361823838A5067025487 @default.
- W4361823838 hasAuthorship W4361823838A5068043303 @default.
- W4361823838 hasAuthorship W4361823838A5080005941 @default.
- W4361823838 hasBestOaLocation W43618238382 @default.
- W4361823838 hasConcept C104317684 @default.
- W4361823838 hasConcept C127716648 @default.
- W4361823838 hasConcept C150194340 @default.
- W4361823838 hasConcept C162317418 @default.
- W4361823838 hasConcept C203014093 @default.
- W4361823838 hasConcept C2776107976 @default.
- W4361823838 hasConcept C2777933648 @default.
- W4361823838 hasConcept C2778265714 @default.
- W4361823838 hasConcept C28328180 @default.
- W4361823838 hasConcept C502942594 @default.
- W4361823838 hasConcept C54355233 @default.
- W4361823838 hasConcept C77255625 @default.
- W4361823838 hasConcept C86339819 @default.
- W4361823838 hasConcept C86803240 @default.
- W4361823838 hasConcept C8891405 @default.
- W4361823838 hasConcept C95444343 @default.
- W4361823838 hasConceptScore W4361823838C104317684 @default.
- W4361823838 hasConceptScore W4361823838C127716648 @default.
- W4361823838 hasConceptScore W4361823838C150194340 @default.
- W4361823838 hasConceptScore W4361823838C162317418 @default.
- W4361823838 hasConceptScore W4361823838C203014093 @default.
- W4361823838 hasConceptScore W4361823838C2776107976 @default.
- W4361823838 hasConceptScore W4361823838C2777933648 @default.
- W4361823838 hasConceptScore W4361823838C2778265714 @default.
- W4361823838 hasConceptScore W4361823838C28328180 @default.
- W4361823838 hasConceptScore W4361823838C502942594 @default.
- W4361823838 hasConceptScore W4361823838C54355233 @default.
- W4361823838 hasConceptScore W4361823838C77255625 @default.
- W4361823838 hasConceptScore W4361823838C86339819 @default.
- W4361823838 hasConceptScore W4361823838C86803240 @default.
- W4361823838 hasConceptScore W4361823838C8891405 @default.
- W4361823838 hasConceptScore W4361823838C95444343 @default.
- W4361823838 hasLocation W43618238381 @default.
- W4361823838 hasLocation W43618238382 @default.
- W4361823838 hasOpenAccess W4361823838 @default.
- W4361823838 hasPrimaryLocation W43618238381 @default.
- W4361823838 hasRelatedWork W1499338046 @default.
- W4361823838 hasRelatedWork W1503249130 @default.
- W4361823838 hasRelatedWork W2014643937 @default.
- W4361823838 hasRelatedWork W2151220680 @default.
- W4361823838 hasRelatedWork W2273958019 @default.
- W4361823838 hasRelatedWork W2587852826 @default.
- W4361823838 hasRelatedWork W2771454822 @default.
- W4361823838 hasRelatedWork W2888454940 @default.
- W4361823838 hasRelatedWork W2917401776 @default.
- W4361823838 hasRelatedWork W3098296129 @default.
- W4361823838 isParatext "false" @default.
- W4361823838 isRetracted "false" @default.
- W4361823838 workType "article" @default.