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- W4361827110 abstract "<div>Abstract<p>Breast cancers with estrogen receptor α (ERα) expression are often more differentiated histologically than ERα-negative tumors, but the reasons for this difference are poorly understood. One possible explanation is that transcriptional cofactors associated with ERα determine the expression of genes which promote a more differentiated phenotype. In this study, we identify one such cofactor as coactivator-associated arginine methyltransferase 1 (CARM1), a unique coactivator of ERα that can simultaneously block cell proliferation and induce differentiation through global regulation of ERα-regulated genes. CARM1 was evidenced as an ERα coactivator in cell-based assays, gene expression microarrays, and mouse xenograft models. In human breast tumors, CARM1 expression positively correlated with ERα levels in ER-positive tumors but was inversely correlated with tumor grade. Our findings suggest that coexpression of CARM1 and ERα may provide a better biomarker of well-differentiated breast cancer. Furthermore, our findings define an important functional role of this histone arginine methyltransferase in reprogramming ERα-regulated cellular processes, implicating CARM1 as a putative epigenetic target in ER-positive breast cancers. <i>Cancer Res; 71(6); 2118–28. ©2011 AACR.</i></p></div>" @default.
- W4361827110 created "2023-04-05" @default.
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- W4361827110 date "2023-03-30" @default.
- W4361827110 modified "2023-10-16" @default.
- W4361827110 title "Data from CARM1 Is an Important Determinant of ERα-Dependent Breast Cancer Cell Differentiation and Proliferation in Breast Cancer Cells" @default.
- W4361827110 doi "https://doi.org/10.1158/0008-5472.c.6503183.v1" @default.
- W4361827110 hasPublicationYear "2023" @default.
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