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• W4361834393 abstract "<p>Supplemental Figures. Fig S1:Expression of HEY1 and HEY2 in thyroid cancers vs. normal thyroid tissues. Fig S2:PROX1 mislocalization in TPC-1 cells does not depend on CRM1, energy or temperature. Fig S3: T3 promotes PROX1 nuclear exclusion in a dose-dependent manner. Fig S4: Engineered BCPAP cells conditionally express FLAG-tagged PROX1 by doxycycline administration. Fig S5: Wnt/β-catenin signaling is suppressed in PTC cells. Fig S6: PROX1-mediated regulation of thyroid cancer-associated genes in TPC1 and 8505c cells. Fig S7: Single cell motility assay. Fig S8: Reinstatement of PROX1 expression in TPC1 and 8505c thyroid cancer cells. Fig S9: Dox-induced expression of PROX1 in BCPAP tumor cells in mouse. Fig S10: PROX1 re-expression inhibits tumor growth and aggressive tumor cell morphology of TPC1 thyroid carcinoma cells. Fig S11: PROX1 re-expression suppressed tumor growth and aggressive morphology of 8505c thyroid cancer cells. Fig S12: Cytoplasmic localization of PROX1 in other cancer cells.</p>" @default.
• W4361834393 created "2023-04-05" @default.
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• W4361834393 date "2023-03-30" @default.
• W4361834393 modified "2023-10-18" @default.
• W4361834393 title "Supplemental Figures from Aberrant Activation of Notch Signaling Inhibits PROX1 Activity to Enhance the Malignant Behavior of Thyroid Cancer Cells" @default.
• W4361834393 doi "https://doi.org/10.1158/0008-5472.22410302.v1" @default.
• W4361834393 hasPublicationYear "2023" @default.
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