Matches in SemOpenAlex for { <https://semopenalex.org/work/W4361834474> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4361834474 abstract "<p>Supplemental Figure S1. Kaplan meier analysis and oncoprint mapping of Luminal A/B (A) and Basal-like (B) TCGA-curated breast cancers, showing the tumors in each set with upregulation of Akt1/2/3 mRNA (red boxes) or phospho-S473 (black arrows), and the survival of these patients (red Kaplan-Meier line) versus other patients (blue Kaplan-Meier line). Log-rank test shows insignificance. Supplemental Figure S2. Rictor expression in human breast cancer. Supplemental Figure S3. Oncoprint of TCGA-curated invasive breast cancers (TCGA, Cell 2015, N = 971) assessed for RICTOR genomic alterations. Analysis shows 8% of cases (76/971) with gene amplification, overexpression, missense mutation, or deep deletion. Supplemental Figure S4. Rictor mRNA expression was measured by qRT-PCR of total RNA from mammary glands harvested from virgin female 12-week old mice. Supplemental Figure S5. Genetic ablation of Rictor decreases growth and survival of HER2-positive breast cancer cells. Supplemental Figure S6. A. Cells were cultured 6 hours with FITC-labeled Annexin V, then imaged. B. MCF10-HER2 cells (parental, Rictor, SFN, and Rictor ZFN + exogenous expression of myc-tagged Rictor) were cultured 6 h with An-nexin V-FITC. C. The percentage of cells in panel B that were labeled with Annexin V-FITC was quantitated. Averages (midlines) ± S.D. were assessed for significance using Student€™s two-tailed unpaired T-test. Supplemental Figure S7. Rictor-mediated Akt activity is necessary and sufficient for breast cancer cell survival. Supplemental Figure S8. Cells were treated with lapatinib for the time course indicated. Total cell RNA was used for qRT-PCR to measure relative RPTOR mRNA expression. Supplemental Figure S9. Cells were cultured 7 days in 10% serum plus lapatinib (1 μM) or PP242 (1 μM) or the combination of lapatinib + PP242. Cells were stained with crystal violet. Crystal violet fluorescence was scanned using the odyssey. Representative images are shown. Supplemental Figure S10. Loss of Rictor/mTORC2 sensitizes parental and resistant cells to lapatinib in vitro Supplemental Figure S11. Cells were treated 6h with PP242 (1μM) ± lapatinib (1μM) and assessed by luminescent caspase-3/7 assay.</p>" @default.
- W4361834474 created "2023-04-05" @default.
- W4361834474 creator A5004009810 @default.
- W4361834474 creator A5005222149 @default.
- W4361834474 creator A5023663301 @default.
- W4361834474 creator A5037252693 @default.
- W4361834474 creator A5037945408 @default.
- W4361834474 creator A5041028923 @default.
- W4361834474 creator A5045897963 @default.
- W4361834474 creator A5050114109 @default.
- W4361834474 creator A5054762208 @default.
- W4361834474 creator A5061679177 @default.
- W4361834474 creator A5070245444 @default.
- W4361834474 creator A5081221013 @default.
- W4361834474 date "2023-03-31" @default.
- W4361834474 modified "2023-09-27" @default.
- W4361834474 title "Supplemental Figures from Rictor/mTORC2 Drives Progression and Therapeutic Resistance of <i>HER2</i>-Amplified Breast Cancers" @default.
- W4361834474 doi "https://doi.org/10.1158/0008-5472.22410318.v1" @default.
- W4361834474 hasPublicationYear "2023" @default.
- W4361834474 type Work @default.
- W4361834474 citedByCount "0" @default.
- W4361834474 crossrefType "posted-content" @default.
- W4361834474 hasAuthorship W4361834474A5004009810 @default.
- W4361834474 hasAuthorship W4361834474A5005222149 @default.
- W4361834474 hasAuthorship W4361834474A5023663301 @default.
- W4361834474 hasAuthorship W4361834474A5037252693 @default.
- W4361834474 hasAuthorship W4361834474A5037945408 @default.
- W4361834474 hasAuthorship W4361834474A5041028923 @default.
- W4361834474 hasAuthorship W4361834474A5045897963 @default.
- W4361834474 hasAuthorship W4361834474A5050114109 @default.
- W4361834474 hasAuthorship W4361834474A5054762208 @default.
- W4361834474 hasAuthorship W4361834474A5061679177 @default.
- W4361834474 hasAuthorship W4361834474A5070245444 @default.
- W4361834474 hasAuthorship W4361834474A5081221013 @default.
- W4361834474 hasBestOaLocation W43618344741 @default.
- W4361834474 hasConcept C104317684 @default.
- W4361834474 hasConcept C107846503 @default.
- W4361834474 hasConcept C121608353 @default.
- W4361834474 hasConcept C127561419 @default.
- W4361834474 hasConcept C190283241 @default.
- W4361834474 hasConcept C502942594 @default.
- W4361834474 hasConcept C530470458 @default.
- W4361834474 hasConcept C54355233 @default.
- W4361834474 hasConcept C75217442 @default.
- W4361834474 hasConcept C86554907 @default.
- W4361834474 hasConcept C86803240 @default.
- W4361834474 hasConcept C98490376 @default.
- W4361834474 hasConceptScore W4361834474C104317684 @default.
- W4361834474 hasConceptScore W4361834474C107846503 @default.
- W4361834474 hasConceptScore W4361834474C121608353 @default.
- W4361834474 hasConceptScore W4361834474C127561419 @default.
- W4361834474 hasConceptScore W4361834474C190283241 @default.
- W4361834474 hasConceptScore W4361834474C502942594 @default.
- W4361834474 hasConceptScore W4361834474C530470458 @default.
- W4361834474 hasConceptScore W4361834474C54355233 @default.
- W4361834474 hasConceptScore W4361834474C75217442 @default.
- W4361834474 hasConceptScore W4361834474C86554907 @default.
- W4361834474 hasConceptScore W4361834474C86803240 @default.
- W4361834474 hasConceptScore W4361834474C98490376 @default.
- W4361834474 hasLocation W43618344741 @default.
- W4361834474 hasOpenAccess W4361834474 @default.
- W4361834474 hasPrimaryLocation W43618344741 @default.
- W4361834474 hasRelatedWork W2026140947 @default.
- W4361834474 hasRelatedWork W2101083009 @default.
- W4361834474 hasRelatedWork W2330924021 @default.
- W4361834474 hasRelatedWork W2406111920 @default.
- W4361834474 hasRelatedWork W2772286407 @default.
- W4361834474 hasRelatedWork W2912656088 @default.
- W4361834474 hasRelatedWork W2958505263 @default.
- W4361834474 hasRelatedWork W3001607621 @default.
- W4361834474 hasRelatedWork W3008678845 @default.
- W4361834474 hasRelatedWork W3213848811 @default.
- W4361834474 isParatext "false" @default.
- W4361834474 isRetracted "false" @default.
- W4361834474 workType "article" @default.